{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022k3OOzexlco5TXHK1uAcTxdTNBYl6UbwYPu6TBh5ulYOhg8N5nsV\\\\\\\\\\\\\\\/HQKHiT4Sp\\\\\\\\\\\\\\\/+wYar2Mc8TwzC3Hlwm9rfQD8NI6JD5SfA0VgLdU7RUjNq5Xg1vAEYXOV7WgXxYwPQzdhA2QjQqwXNtnvPjiXZ1YgTefFqlG0+ipBPbK+1LmeHx+ZsJOuMftC7IOYt6aruuA2pWpP1QcbDPefHuRSlWWRJ1Ju5WsSuJcKrgRiOLjec6QSzRDH5F\\\\\\\\\\\\\\\/AXa6farTFZz4d2MMQDDDLUmtL4jTBBYEde60dkeJmOlkTTEM7Trpn\\\\\\\\\\\\\\\/2CfA52DRRkYVGP+uu61PTBcgrHI6FnNoW\\\\\\\\\\\\\\\/caZvtwRH\\\\\\\\\\\\\\\/+GYHRug+ksHLVXL2fbtM1QyhPW0TYnJ6JfuOKqhWBabW7REuGaywbyhCfhYq0M0431pFjQWx0uOjYlxRTlJVYsSrRI3EMYCOEhuQdmvPDmTXseioAeN7DITFq\\\\\\\\\\\\\\\/Dj7wqzZ+pK+MvB\\\\\\\\\\\\\\\/iXXWQ7Mgh1ZggtuqatkZB9KEJvKL5IK+nHz8YTdGxX8Qtc7XwFJ9b26gt2muy8VFUDWH1pI37PLi4r2HboeKKid+0hdw3Uldk11zgrJ4nDhcvehUYxafPZWyrCn1aX3sOku1lAXEJNlAdgWHsMRXIZHK6gWLcSpH+1kdjspW\\\\\\\\\\\\\\\/AZ5CmcWD1xU\\\\\\\\\\\\\\\/Iv7zVmgBCLj4V2W36JSKQ+mlsDTlkLBT\\\\\\\\\\\\\\\/MnA13wbB2dLmPZGQA9UPL\\\\\\\\\\\\\\\/3k+K4YwjE0H35n0KhJfcvgx01GrIm3e2iDDG\\\\\\\\\\\\\\\/YzFJ8EwGAAeW9UwSAbY\\\\\\\\\\\\\\\/3FBdZT\\\\\\\\\\\\\\\/f2Xs7MTb1jI+eJs9cIJdGZGSUamWMt9tZhqSlx11t37M\\\\\\\\\\\\\\\/e1JjSZLp8iDhr84PkqAGiqoPOBGGuZ5YoXFuf4ddcEmsR3\\\\\\\\\\\\\\\/k8siDu2BcWBMvwOlIwJ9WAUQYRQ8kTnFyCWU+a+XJWyBK6Ach\\\\\\\\\\\\\\\/P\\\\\\\\\\\\\\\/TQhv26At0BvPKGZPyb+FUT3gQ9\\\\\\\\\\\\\\\/g1naw42Tm+JuoC5DiJW6cgOYtyFPW5cmSA1zGrEa+eXwZXYNx1akuaWfj\\\\\\\\\\\\\\\/gWtPfA+2WWVax\\\\\\\\\\\\\\\/db\\\\\\\\\\\\\\\/pKVAhWXhKs4RcaZBpMR1rja5FQPMS11PbwH1enyfth8Qfc5aL9xmG6VpJFi8cS5kBwWUZjysxzRykKw5aYanmLL45u4iNDOuLL6P\\\\\\\\\\\\\\\/RhSYu90PIVhtffF3Q63gjdjTSS6dikCOzMUTI3LmL1w8CwhBmQf+ttSU1DkOpoO2YsOXnqSMO8xG1LQixHFYwBynG9SoKVCIkjBmyVyJC0KRwO0ua8HE33lw5gyGpkncknIaegiSntlhDKzibxjiyz5PzCoSzFq0FvxLP\\\\\\\\\\\\\\\/6vQgTO0sB4F2m4CQQEXC1ezM51tEpWplPWyybBQVUSCRgIccrViBgXugTEzujB0VgwBG061hWaZqjswklC+aspQzuv4OWFWeoshfMizklhlyqTGV+bp2E6Bf9Qn6p58Ih+hR+krc1oeN28UpTudTN0vXjp28tg2wwAubGkEWdV0kHmfCbJAv6Uy5Weom1CwGJKpgYnY\\\\\\\\\\\\\\\/p8MwGABowrt2O4bUkhEkGNBxAoWGeEUDxoYokFykf6Yv2vF+yOckJEroPIsPPOhDw+XoPTlCpbfKpgvhYAr1GKjGEjU51T22TYCQwfCkND1C7VcT8fglQJ2C6Nbs2TJL8wX9B2ZmoBjp\\\\\\\\\\\\\\\/WuhW1vtWZ7Nreh+7guVNW+SgOSWPT31lPvpWJYez3lMuyrkGo2JjA0jLfAEeQj6WVzvkyEfTJTaNZwTpbrzPnK6E8G3+pE188FZHLJhA7gF8R4+epLnFGfFb1DxCFOg27T7FbvTu17DUYp7U+5ZilwvoJbjWdrGLMrn6r2KvdbeJcOUCFpsusoDNc4rEqWKBaOtk98U+bWIowzeUM3IPhFkEZTKL0gEzUJfLB1KJSk3xLfFWaRMBEV+8l8p2rDzsh+6fLfu0LCw\\\\\\\\\\\\\\\/T0Jgj3hFzgkK0CnpF4QnTQ+FLuYR8Zkx7h4y4+MOzGz9ruJIaRvVNqjUKtHg0OlYXMi+xP9IRIbJWWsuhbBy++NJHKKt4rEaIDGL64ouSAB2Ust+1dnUYrs6L9OAOaqgbf5AKvmJ+8jz+rzqsJ2p5jzuNbeEqAVI8kcBcCIgLaMQL6Dhe8defLVjRm7CjtXYQgYp40e0AifXIbEz0nYVB\\\\\\\\\\\\\\\/o19m68xXiwD2ZLWyfwUKKZ6kqid7zcok2SsJM0qxeMp0NXHKHw0v5hEI7vZQhQ\\\\\\\\\\\\\\\/wY4KSHsIRWWSx2Rpe9eYULwR4u5PJ7653Hl\\\\\\\\\\\\\\\/qcgZGi0OT\\\\\\\\\\\\\\\/vFw1JanKbA\\\\\\\\\\\\\\\/nqUdt4+eb1JWAca2doFlvelKTJ8sYTXVTqvMt6zUetAnDz3Ji304yz+2KJ5uhB5o9+xI8mcySobqoSCw9\\\\\\\\\\\\\\\/jOZ7ITsrdHNtqH0sDf5I6XcAIzsykHjHU5cHTz2wT58YPetq9CrcVXirD8\\\\\\\\\\\\\\\/oWpSsDtr8STl45swM7C9dURQGJQSnyNpUON1d+E5IIyYG207M+z8jylsq\\\\\\\\\\\\\\\/R0FUFid6Z4iEaBz8FrdrAePjyS16yPJvPwDzuXdixZ0\\\\\\\\\\\\\\\/+FGs8gVARsCPIa3R3sLk4lW8NhehvjJ3lLSHEueewFLuyxmC+MhQhLh4hUWFFhKyVQdxrDE6dvBJrHUS0sBhYitbV7TIrbholl2dIPH1d7fbpR39V3zRxO0fyvnXQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022yhsxh32Y9sFCIgQzbTDHYA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fc9d458a427712288ff9e6f432768e9623b8e75703e547567a4999f471033fa2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e002473.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e002473.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002473\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002473\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002473\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}