{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022JevacLesPBmIMZ9gDEC+7xl2yh9oF8DyV40p2WWreyGnX5WNZPKuSxU3CaqOs8VNZcAwCWhYdLBYgDPbn1F8lV\\\\\\\\\\\\\\\/gxKlVrxzkH5v4UoKL6NCVuQXGcHbyP6V6V+310rHnzfocJhaHSHtEkxhbHtg8RXY2wC1fT9NfmNdECEsHi3c2rJmc0fnLII0Cam7lxjMOMjvfZbOys7DPfPxQ91xt1NTgFOGHS5xunDs69e61Cnvf0RvNsCfGeGSHGU+J5RFG4OzdZiRh+HUsw6PJRpxuZDVYwEg0I9eycIGx7ZLLRFzbqoA7G0TQHkuI4qM4lqUsNZ9RwMbfn0An4pIyOB3RsQq7ZwxHfyVQ0GwH1MGWqA3xHj71BFv8O1mh6Ih7dSSV0lkY9hyRBbCw5PFfrnLvVMjLWcNsHaiQLB1jlkN6x9wgnUEMzBbpsPy6cAg\\\\\\\\\\\\\\\/zRZLIf5G1aZGP2LYeh+UfWmJMO7CR1CMqcHWmHOZ8S0udnABLehCfeg7ijNrMx1t9sozsj\\\\\\\\\\\\\\\/qv34e4pZz5S4TXnaIiID2k5burMhyTbo9AZ+LQWM3g8uRkSHnqwfyEpxUSj7F5wCBLdbebJt3dLZry\\\\\\\\\\\\\\\/o9uHfIWsJ\\\\\\\\\\\\\\\/3p9btxPQeXUGhO0cqkly8878znyMHVEDImnVW5\\\\\\\\\\\\\\\/LaMnbUEdp07H3wFYrTZ7ekBnCds7h\\\\\\\\\\\\\\\/F6kOZa\\\\\\\\\\\\\\\/s8SyKFF0joWmbMozWMEg3evnw7RrlwHKdDLG7+Srass5xGfXJO6zjVjjvr8rSdPrD4RCJ8x\\\\\\\\\\\\\\\/8iS2ROh7xCbXW7mXf9Z20OREvo2bef0xk+6d8onkc4Mv8Rk6FlVMAqSf\\\\\\\\\\\\\\\/Likx9AKDJP0SuXVnJBeVg4JbsBuvn6uuHK4CkBRKw668QHcrLBJhYaSrvkE2coUjdhTuBG25NBb8X2O8ABuBbFEhzATxRBC0JadwwzX\\\\\\\\\\\\\\\/AoLQO5s3WTdjSBUlk2h3N33Gmlx2Ul8mepvpKeXeNRcyqOBVHpNSGg7gOzHSvpm+1Tiyiv3UYczPeMHJpwnGoK3PJd2GSPJ9pp2MWcMg0SjpB4vxcTt8NOAdIgqgHmziUIxPMKEiDN1eCV6XoqdyyNIMAItCFEi1Wlr0UaINs7jug6w2eNegMtEpHrlu5G0oXPzwM1wMNKjUTb2fJZDEyY2bDruhOIBvIu0nGk6n5R1w3bKviA74s48xKBvj8j708rQvLKgkfUYFn\\\\\\\\\\\\\\\/j8aFivHThSV66fFmi9PPGvlGMUYssI6\\\\\\\\\\\\\\\/s9Vkrpgn3CRQvksKkHS0o8mDqIPquidNyz75stEsDXWua+8e9UWkC\\\\\\\\\\\\\\\/G3JHd44uLWzEHe0FAOhBxysnaGXVEkgaYs9yDHtmwybZMMTsuswi7gDkQF7ezoSdys4DCA02AY2miBN0xfcwjDECYTjGgk+t1BmemfF7EPdKIyg4k7CdWT7RvgJEIxCsynrLGi2CHkOoCY5w8ONWRAXV\\\\\\\\\\\\\\\/i\\\\\\\\\\\\\\\/fuabDwSHD6zmZGrMMQiXQwg7cgbRd76D6Ah21zq+8HSHE1CXDsv5XJx8h80uJz1KMEeppdqnq+2Gipb7r1jIMRKGpY6D2urn3HD6DXVP6ZILZ746IPW4+THTjFUMajE021npZjx1g7De\\\\\\\\\\\\\\\/3Ma5b2PKpmErJf7Oqa4C8zc+VjYj0RylGCmshA\\\\\\\\\\\\\\\/69mgJMWiU\\\\\\\\\\\\\\\/PA+asACYXLzj6BXsD5eOT6AnoBI52j5ln1fYtDz1KU7s8JMhSMKp2U2n8RIKuUfa7cvYVmJcwxJvHC5irhVKprfqzgE8T8xvK10QYKJfbgj4TRWrcdk\\\\\\\\\\\\\\\/dNiJ\\\\\\\\\\\\\\\/KiNLgj8jSgXW4zOQ8rbM9mSNlYtsp4SaF8F2nsrpJAebqc1eqJeGfpUbH+JtYS0478rZpp79zWBvKTOhDqRHT6NOHwcLVsimfWpD7z\\\\\\\\\\\\\\\/q9j5nnnyBP7Ob5P4hwQzqD9IXlrqyZGbuVL8XUto3rIzrxQZFuB1lNKH0OyhrKSy9zxlS0F2U1UCbPj\\\\\\\\\\\\\\\/tNudlGtg6+2w2ha669MYQJIM8TO39sxMBvF53oMSLM13MG20eldAekqBUGRSm3Cc6xRP7u2eFg8QJ9ZWbNptUFWk2+UbBdzgXR3kr8Ak6ZPihF24gMlHYIGXcBJ\\\\\\\\\\\\\\\/ZPvt3pM3q6HfMBUjBTv1WQCY5ZxaGQAOzDpXUnEKr6DTHYkPbDFQsgSb6Z4ohX4W4K0WlMGF7n\\\\\\\\\\\\\\\/yTHPaz+r+72ErCkbfjGZawb3yoE0VJzJz0HyFEjJvp8OEGNRx0sGrZiKo80noGSklh9VjtyYdRaTy4cjzzhHoYDBJ12G1CP8caFIc9q+Zo9GBYazGA4fLm\\\\\\\\\\\\\\\/82lfzPYGd2dgJEuAJ6uVvd1N8r6v0KPkqvOeBryc+IbxsGDFXoVmYABzit77pgjqi7wFedY5gwWLhobdUZj104CXpLs4avurwRc09UxZo1Ss5J7YNlVWPCFldg2zQknwbWzaYizjiIRT5oTiAmmX52PXRccfwOfJmaB8DIzgGzNG2kPxe4PME4lnkVWyf3+JiFdGEdugsv0AgXXCF\\\\\\\\\\\\\\\/BYZJt8SFzxGZ+hqZiFMurZVtJ9UTAC+aMljmK0mxZt97IM4aKaxIvwNbQEOTImfwYwfN1i2n8BjChEX9xjG0781FSHF7r\\\\\\\\\\\\\\\/4QvIzOZRG547K8UOhQPGnAFixiOQvaroPlx4S4sbQzy3NZmhhQZwnlBgDDVxRzk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022CNV7c\\\\\\\\\\\\\\\/HXqoJ\\\\\\\\\\\\\\\/JxXq92t5Fw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022acfbdde7378332ed4aa16ab379b4349192ca1be2f5ee358d42facf050df8a6ce\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e002891.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e002891.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002891\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002891\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002891\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}