{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022L2qQ7VFDUJ26sdRrlbMRSaVofUp8z1b19WuX3cZS1g\\\\\\\\\\\\\\\/Rmtla9BN9+J2Gaaxwgqe+OxdQeOb3xRirBX83V271DFvFHKoNqpwMNrMNqMMpgslNeLU2v6kWpDNj3GABOHirp5MfNfpKBpnf6hx5lMg5cfWdZMdkF4t1Qk2wfzT3Avu6XEULo\\\\\\\\\\\\\\\/Yt8N5\\\\\\\\\\\\\\\/si7mv0pY1SEMkdZNR98wzKAr7aLmrtnqOXNQoYPxr0y9+BTUrpc2W\\\\\\\\\\\\\\\/GIrHo3plDDiuX9WodQ0kABlznEq+RSBOFHNHfsJrZxGfGbN+zhgnuzT1yrL8V8JMgrUunvUd+DsKdiBEdLC0NOw9weBD16qQps8CNNQ5nQ0WDwgVD\\\\\\\\\\\\\\\/vlkJp3XkTJ9Ul+XI3KTbdMgrg30iK7tJyw5tyKoPRMP\\\\\\\\\\\\\\\/j2huDvbTaC7hBLyF95qJVJoz3cZt1q2uBIo7AVZRXNxsUTzWsJQpGEOaeGKMuzUO5yLNQyaNnM8RDPXmm85ob8MBGdNzSQsUSUgn\\\\\\\\\\\\\\\/JeyE8PAOV9g9QdHJJsQhM\\\\\\\\\\\\\\\/nSzc+qqtkdI8IrKSzmaHlNHRiG0dVvTUUWlFH82zE\\\\\\\\\\\\\\\/nSneKeu7i2YOtuLSEijsBPvveSaPY+pVs75\\\\\\\\\\\\\\\/H0gpI+3fpScUCGBIQXtSaa5tdpQ6WfwVm6BLwPwOaWnQ7pbaUeZgSrios8R2sSyQRBSGIE0iLKFe2YYqjf67dsjzQSysXaMca9Mqj+YifXjbe0lWkcg2SL+moLgj9yQcidjy21kYkj\\\\\\\\\\\\\\\/4fG4rVqTAGcOaKS+HTGHJLfvBzYf5DLMoOmYXwWeNA93IKAltYWVEJbkur7C5JEpLPLv2LaqpZSC5lbs7CexavuM0DeODzrAxawSBuNeKdp+INxvdDt0Cuf5\\\\\\\\\\\\\\\/XndaKZeggHh49qpkKElcufMhrBicvoVCraxFonyK37+b10O41xrYuGSryyCgnsPl+vOFEoFLB2JWEdM4H+E9IpFe+MrmtwFwyLfeZb5VUUdvIoLArVj09rZ5zzRjyA606nQIclM9ejwWDAeM2tLFakKeHgnUunZ33X7h5xe1toYRvDUPapz71HD1IdkWPJzos0h3ezQWol3ug3lThchdH\\\\\\\\\\\\\\\/zP+Qw1iMfD6MTkGep4r+JrIHmvlfnTB\\\\\\\\\\\\\\\/5+G\\\\\\\\\\\\\\\/m09VrMmq6rJcx\\\\\\\\\\\\\\\/eFt7nT925eT41h2yyKzwzkeSqNOGZd\\\\\\\\\\\\\\\/jWH+RxffmWcHkkxQxtjCLrsc+LyTev3QDsAWGit8kLIKaSGCu23WLSV40KeWHv3Db1hLUyyRTKf+R0kOhGvIiLfjnSlEbPTrnB8T138dUXAl9loZeS7796GP2NiBf8zateOuHcnXgN73ZdWp5wbD1WVlAG9fJ5n1I5T4kHs9C\\\\\\\\\\\\\\\/XC5c4jq6KMr1YHQk6GystPemuZAx2LTv0lB+AEZOUpxLbTXaKLM0GWDiggoWSEPcaFmMgSpOfoArJH\\\\\\\\\\\\\\\/Rcym9z1fTFx+\\\\\\\\\\\\\\\/m3ainobNlCHBprP5vsMd5g7UXeTekjgJEmE8dT6ViX\\\\\\\\\\\\\\\/0X6MeJO6YyrTsvA7SFsvn0ENkhCb+Y5vmzw3a8e8Jyire90edxI2ovyAoerASkvQ1sEfBbqRgO\\\\\\\\\\\\\\\/KbNrZx5AS6wrf4bXqttL13iQaNHj3Bd3eV+mZxVBWRgMZ1sgv4Om0rJOzJ1cr+t4tTiTMiFcl2w9AnZvOPDgNxt1V78yTsIzeLmM2vPhnHX3yknEx9Zj+V9R5xaPIF\\\\\\\\\\\\\\\/rxKDhZIe2uqsoOR1ndlRxek5fl22Qt6Fp4Hw+1ZfnKzp9GQ70jj4B01dMbFr74MUOjbaDvNyO7KxXkAw9WDOPKtvPLeifRN7msv577igHEaLfESkFxMI7uqRjtZH+7xCOkTTlfUPTObaOTRxQ9JXqv0IrSB7c4x4t4SfRlsgIFluLXZvYsoAC85keDWdzQdesly02w7ZguDUWCOkc36gby\\\\\\\\\\\\\\\/NHtyEAjIPq3mdU8zFj++u3H5KVsWGsZdreNjV4BwE8qjbeIoOuBpQjpXJ5BVvYb5VyDyqQ5dmAc4zIYqPkFlDeaOPAc7HGgxstuE70yaof0w5qi1orYyO6RBfD0orDcfoYq0QGdq9Mk7oWdyXZ2BK3L\\\\\\\\\\\\\\\/8vF1SnfHbhINCD7cabVWlTTwmAZUqUAkyhDaqThGEdTBOU5AobFrm+e2LsGn\\\\\\\\\\\\\\\/boTqWgyaEHZ7ZNgr\\\\\\\\\\\\\\\/0vbBXbDIV3irOGljsAx8N+lK99lgtMal5i1XQvIYWjYSG5vUZ2W8SdYq\\\\\\\\\\\\\\\/KtO8YMrTA0bkcBmFRSOgIpXWuq8h6p\\\\\\\\\\\\\\\/OQPYmTBuIpDfll+Dr5CbZGn045xMNrvhJ76CLFGBGghpJ4kq+wEKMTQm5KjaYNt0WnmfAwMD61mqBso2QC91xd60mUSPGloiMeJcTmWHDeS4Q3PGw+WtAo4lFdcR2Tytu3Fkt9eHzivseuhuFSn80SqCLheT\\\\\\\\\\\\\\\/iEzN4wYbtXOGpcAFcifrAr+wqJz9fJ9IrsuG9DUVjEVVplRIHyWiy8\\\\\\\\\\\\\\\/9ynqJ60UUv4dTVHefSoN+OsSM0Ia7uPimFpXPNoxVu28S0v+sRMGySD\\\\\\\\\\\\\\\/vVfKa+0v9eunQUaiu5YVsNPedZjCjhs+9YmOMw3x4UI9EZMtzlY6LVojmcKCLGR+SuQoaTDXMomupToKldJrp6r0JbA86UDojLt9Tlewa3FjL\\\\\\\\\\\\\\\/RnTfEJdrQ30VWF49zbNAcrHfKaBEmv9go=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022a10z669mZcaMEI6bn7MS+w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002283fc0f0de054aeee7929d17876931a567ffec930b0b1f43a26d06e16d92d6eeb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e003000.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e003000.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003000\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003000\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003000\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}