{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Y5WhEXIth+gIBgSf1a\\\\\\\\\\\\\\\/xZrSfP4LgFZ3LXRhGr6EAw773RERVi+vOVyX1f+DZlt\\\\\\\\\\\\\\\/GZzX\\\\\\\\\\\\\\\/VtsmMRmK8cfxeDY4ZcjxeW+yhVR8E4NzBvjHArBjtRrT4g6gK\\\\\\\\\\\\\\\/rSVURholc8dfdK0z8\\\\\\\\\\\\\\\/Mwnqwa2OYaIFgrj3k5aue8QDcLxLeDqjC2s4t0TF+m0W8yGvtxR9vbGLctrDSPXsYOWoPQ8Fk3QN9NZ9Ox4YTk2W\\\\\\\\\\\\\\\/DG3XiP4ziDPWDFDxcxDlZYp\\\\\\\\\\\\\\\/Sqe2gy1qmXLZ0KBK4FbO1nyiZqTw0riUtSMImFzSSEQwlisG4SxGKstb7fWWHC8nFDy\\\\\\\\\\\\\\\/cGQel2eVoO8HHwwbiCt6y\\\\\\\\\\\\\\\/HAu8wnC6I0y0pcKocAf9Aa\\\\\\\\\\\\\\\/p2\\\\\\\\\\\\\\\/Ko6Nop7HmkVpUipXa9hYLhoRwFliMjz8Zb530PSIK8iACaOjIAlxci0NFY+rwbVrF\\\\\\\\\\\\\\\/2HXUs0WCC0tbJ9dXAo9MPbchePgaJlax\\\\\\\\\\\\\\\/fuarV3Ap71UH\\\\\\\\\\\\\\\/vSLadYsqcOfLtGFC6K3aVN1wUubrgz6Q43QsuglLqYwnTNqHrCmhTx7eKirc+Q29khXMJxjmnNRo2+ePXody+NAPeY0NnsuD261eOeiNoU6GPW95jCrTLoIKYigF8AVZKz720CU6DU2TPPqsP7VBI7OtXE4wAnLBogIUd+KNrgCjsCBPKig9qXejuJTy+A\\\\\\\\\\\\\\\/jW1ISthi3Sbg44c2S6LD3mdRfwyTI45Q+zdeVEFLqkmolk9hyNF2sUDAep3Y929H1\\\\\\\\\\\\\\\/FmuEP+NBmucfSYW6TYpWhT5bM6UPEDycEnWKviI0TkgD3ctcWBonOhxhS8QwZ7HqyMN51br3ynawA0ETagX2EfJxt\\\\\\\\\\\\\\\/N6mSeXv\\\\\\\\\\\\\\\/UBFZVT\\\\\\\\\\\\\\\/QxhGs7yV0Y6PlVQeFyaTM42lNCV2BLy\\\\\\\\\\\\\\\/FD4T9SSzh8Awa4pU\\\\\\\\\\\\\\\/IATH5SzsW13JiSkAWwNAcVCtLyFeIO6sSYfX\\\\\\\\\\\\\\\/TMLSsHvnW6xLAmbUFaKIwt753Ie5YLyz+Uctk4u3GlAHdBl4YgtQ4cL8XaIo\\\\\\\\\\\\\\\/ciEzqoytlbpEKnDFCfw9SaIobrFxuyAW4JJg8+jgzFtGBuQt2+B+5r9QUHjHJu4KYbwxWBbw2Gl75GgSKhXnsTrtlygN8ajElS6rYQlpxXBdCk9Inj2IBtU\\\\\\\\\\\\\\\/V26\\\\\\\\\\\\\\\/OKogM11P2TLDhq6T1Hknt0hQlTCwZEhzd+Jfz4n5Jvue3mX5wunVnV9ZchE2jq5LvLlk7tpZKY49ODo7NFhom8maZXiVUvCDCFLrPmu5r42gBsSplKsqaCeC5BjRArFYPmhb8rn8YGCjPqQQ+FzO1cDBAXbUQcVFwobmYAYrsVmknMQblW4TzXT9MSG8rNaXiJ+rkkniO6++kII6GXkSlnYoXsth3ttSuLQyTzIQU1AFfMqPrfRKHFq3Fn3v\\\\\\\\\\\\\\\/yjBAeW9snswF5R2qtDnx7zp0YchZ0khefrlrNalVywEmRUg5pwFA+2nCNUjwRhqpRCwE99hzUdvDBNyBClv1cLUBekpdy3IzzJ8ml+TAq+gB+e3G33JnVxFuxJYqWT9jTEAekJpYf6fzKmYZYZ4aatNsT8cvtU0tNrpdEkNAYCe4MVBe5sBIEHgCnVMjzvm\\\\\\\\\\\\\\\/mbXRJ2dVp9aqi8FpWyy\\\\\\\\\\\\\\\/zILNDYK93jmUsa\\\\\\\\\\\\\\\/mK8BGW2J+\\\\\\\\\\\\\\\/clhGLXEI1TB+DuyqssXetkmviN5ArJFtLx620mHb3\\\\\\\\\\\\\\\/3568vI9S1nnn8dV1NfTGRty49j9acBWaQ+xDa26CECTJbCa8lrK5ORBJNqqBIQkHiiLBUCbrJy6uIlhF1olKQUiL82CxwvxVI3Ixg+huGMaxALbjRpjBuz375SBqXirwP3p\\\\\\\\\\\\\\\/VuIAlfSaw6Uvm4\\\\\\\\\\\\\\\/uGGZHdEbuHKFqXLNZxrhME2ZWBzi+kqO8HLbD8hxgW6P6ige3H0DTsTmKRvSkdZnBg0RtFNyMJf+136QeD\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/pVCxSnNnqIuxerkZmjptmGK+YK1XEevKtBOx5hoKGD\\\\\\\\\\\\\\\/oZJzMw46+xUdFmk6mN+kt2KOQvwDsQEniDnkhogVcwqeKS8Z+GaOndAxaVhvE6eazcNwb6cwUrAKsYk5xIjjDlmZL3dYWr99e57pfU17kySYW\\\\\\\\\\\\\\\/jgww178ttsYUMmpP7NmNVTdx6hNgk078kAYtnK\\\\\\\\\\\\\\\/fWCDfi8iossmC+FfltfPjXN2Y96s0vKFu4s2G6bJT2n8yFXKPM+f3CnxFoTD0fbKfAq5zgfgYIqqnlRJZiY4VxrgRTkKt5tIaUHd3JuOMKMdEQe\\\\\\\\\\\\\\\/cPMb8VKm14MhLoO\\\\\\\\\\\\\\\/S3HJTwGlyP2L406r7k26ikapLTslretU7JJ0Sl4jpnlpg0MYbAkuGrdZsc5YAwbne8QjL\\\\\\\\\\\\\\\/RzAnJoTdhfpmZwQoSaSEBpFTlMzCqMVDeKp\\\\\\\\\\\\\\\/xQ1CmjxIhmdRZ9AS4R0wwV6n9rwLwBKUn1f+tl1Yj0tTJD+Sx9q6CiWDDImVXnDFv3dRJZnfLn9RH+PjywQ\\\\\\\\\\\\\\\/dKygKeCmMkF\\\\\\\\\\\\\\\/PgOjr60mYlfy+L6i4oA3XtgN9fzjcEpnbC3gMGZQcpxriANy2e9Y+gFbKQFMcHH677DqGPGRqvXNoe9rIYHVuqFSI5s5g9aYUzMRF92DPUVjfHyYJZUyRC8k1xK8ayN\\\\\\\\\\\\\\\/RF4CpCATZNIoGC41SB\\\\\\\\\\\\\\\/Q\\\\\\\\\\\\\\\/873WIodZeuNN9z9qQkTQ2YDXcsFNoJuXPL+5w4nQ4JfmikPal57upob62oE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022cIdXy\\\\\\\\\\\\\\\/V6Q7At9Ba3Bj8n5g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226d708c4ab65663d555f6763cdcafd69c8e86bf902270c5203e1acab750b62b6d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e002547.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e002547.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002547\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002547\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002547\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}