{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002272lB+\\\\\\\\\\\\\\\/jCE7bFL2IWqtH78UVYc+9iZAYwOdsk3Y0FT1q6RDAsNEuTEoglMx14u1wJg+eVnDA6qTZk\\\\\\\\\\\\\\\/hT0DgzzzICMl5b161qaGkTJuC3Do4IOuMqbHHfboPTQH2QH2iEVw6w0q0cnRgsQF\\\\\\\\\\\\\\\/h9Ry5m5LnkDvM4poSOsPTy1HxDKtzdRtwN3e5RiVmncZDXe\\\\\\\\\\\\\\\/pfk1nRWBWhIdLsVW1N3cx6ajrv6++H88xXwN8RGmxB53dw96maVb2k86JXMVNtyZQzMUuANVx7eFGaEa\\\\\\\\\\\\\\\/3B8nYEFj2jZQI5Sul07DHRIqxzjAdeD7OFZxu0s5Vx3uDcmrgkTvqc6ycba8NPksI1BgSGouZIr0QEhXqjQWNcGQDdvEvf6qqy20S3uj\\\\\\\\\\\\\\\/uwJ1rpdVAEgAzihJkTzWaYmPKdqltsUwtfHFpPvS6wdMh55QqGL6Na9r0AP0Klw3uoD\\\\\\\\\\\\\\\/WgMQxfHreJEdkvp9E+iU\\\\\\\\\\\\\\\/wHo++plpSI6x834Gq+RE\\\\\\\\\\\\\\\/UVb3odzpzOqyWIav5aA5ji8OSceobwrhM5gBrtRJ2JizMFcdQTtQFa3SXIFBdBZXmnuK5OSOQNvU3B6KltUeZMink6wKThyI1Qv\\\\\\\\\\\\\\\/DFZ8Oa4ZWxFYgB6KOl3M+90KsbN+mJTScCy377PwwBc2SIhoPFHbMDI468+WOdEV+u9djebyBEE6BMO8MmiRvDx+FbWY5RdqlUIbmFwE4juDQBTk7guy6PAriN7kctKD4XJLrOGUsg3r7ahcN6KPSf6lWj+P41exP4U1VfMyWELbAiP9zEV4M4FCeWskvzqhkUXxQqjZEduHqCRBQ1WsPHp1ve2Vn\\\\\\\\\\\\\\\/RhMRavxwYObJhrVY0RQrSyF0XipUHOKYnK7burH3AA7\\\\\\\\\\\\\\\/kDBIXmC0ZxUy0aIy\\\\\\\\\\\\\\\/kRjfoAC0ihyRKGUcCtauASlb4Z+q1pVWrD1naqXCkx\\\\\\\\\\\\\\\/Ol1GonJywnxl5KXwi2tio\\\\\\\\\\\\\\\/seN873HESu4XiGLrNRkJ7feM4DnflPJz1mKXIjyt0zoE962vaSovNc\\\\\\\\\\\\\\\/AOeHWmf2gbC93vnzjODVLq+sYkcSTOMdBi0Rf8XEd+8dnef2pPreTZPTLSH\\\\\\\\\\\\\\\/RhIONIrTXNvylVZDDiV5c8SR7m16YDH8Mo2mH70K50PhIkbE7QE9NyPl7Zby72EvU95s3VkPbBXpma9aQazZ5mf5R6pvMxFh2rpA5jsU8fRwTdddz9\\\\\\\\\\\\\\\/m7SUWy1\\\\\\\\\\\\\\\/ubB+nvpbyY4Kh\\\\\\\\\\\\\\\/whNayyamY2DSfc7BjBZBjuPpbDYMB+R7xbVpOqEWSQs0zHTA9L0Wml7xhFeSw7TzriUwho37VZnNe9UtKbNqL9xzBD1xszG4ehqg6hJ9QJ41fkuLHo\\\\\\\\\\\\\\\/+OSrit4fHKKShkCPV1zy7tji3pijNK+x3S6sr31qICgjDLvoOu1irKBK6Zee1uefYMV+5ZuFXSWOvZrlKotBJG\\\\\\\\\\\\\\\/7EHtEWJO0i\\\\\\\\\\\\\\\/sY48f9h\\\\\\\\\\\\\\\/LIMJUFpwXzK2HpsXIDAzFCAF\\\\\\\\\\\\\\\/Vo3bycgC141Pmr+Trl\\\\\\\\\\\\\\\/MiyxsWoFLdxFnyKUcuybo0e4bh3aBU9u8tqzS0oraDOiBPdYfoAbOcXPJh4DG\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/END\\\\\\\\\\\\\\\/bXYKQZZ8HtdR69ijfO3EZa+BZZaDS8oq7YDgUJEbul0udI\\\\\\\\\\\\\\\/8kI2YoMCdMHX6P\\\\\\\\\\\\\\\/Ypzpmz1dhSWQttck5bC98Q\\\\\\\\\\\\\\\/C\\\\\\\\\\\\\\\/PJGyf3KOUQ6iMJGyW5avgYOLOtPtGsHFP7R+JIGFyhl+Mvj565XNYHGUmW\\\\\\\\\\\\\\\/pAWCIRiUk8qDSKOGOrjdMT7+zpibDSsVLIgf7Nw19tkvmfQr7TvCyddrVfwZ4WiCg8+\\\\\\\\\\\\\\\/qfve91zhlgvy0r\\\\\\\\\\\\\\\/yLLD5DYxdocAdZOloCfb8ZI6KUxKxOPmafivRP+6Zre1wUVIrhggqghVcI1AiF1waHTQN7DmFNdLkJi2QjpVNo3HmqmyZK0AfvHGame8eLPbnr2wRE+A0IqISCiIMubZ5SJZUZJFBgXFUb5Ah+oGeRQDZnzidbnT89CfSp1sHfWzmWFUYBY7NNdpN94YHL50g2Ktue+Ju3rB+mXsVpKdeHNtBNnMcUbwikphS7i5UsnE1COLi4aDw8J7wyivjtnYheIDgcoe5n2KhNMqdkCYoYENh\\\\\\\\\\\\\\\/8zz0OOo7Sj6K2S+qexvSCNE2i2EP5S9Gg1cpCOn+3gztXfS1SZpVfAUNqkwcnEv2ZTDnmpfAE8yVCv61mLsMZhBVZJ9+WKLPlIqSZywdV1+qLGSbQHZOCHuKgCsVlRjm0PkbNv5HUJe84lsRV0OwWP79hxrVpwTZP929zt0y3EwMurTmuFNMlJHnssYpwBT7U2JKJ9fqWGVNoBQSAVp0BEgACMd4Pq6XhN3mFZNU0FJX502XIC+PFi\\\\\\\\\\\\\\\/KjDCCEDEcDVNJ56SezRrCNixbBBeTYkraIiDBQVIXupnUceb8FaIBgMmbz62f+1IR5\\\\\\\\\\\\\\\/kyAKQncAL8wGqawX1McuXiQcEjh9XdLuSAqyBLMQHwv2J6wmEnoNsXF62O\\\\\\\\\\\\\\\/shR6olHQzwy54gZ8TOfnc8hBT9OFHjnZMtbu\\\\\\\\\\\\\\\/fYyHNsJlcjlqPJQNIC1QgB4YZZv4\\\\\\\\\\\\\\\/6rUZakVs+W5qochSKi0IZV1574r5s2AVjUvb4H8ibrBBh3w\\\\\\\\\\\\\\\/vbQXS2DSzlQDqpaZACq2Lqi5zr5A+ebGTOCpdsw7JtWkPCnj32bvs9UV9w6\\\\\\\\\\\\\\\/2YhJLZuF\\\\\\\\\\\\\\\/wOaBsJzyaKL7N1DYbo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022FvKx8xftsgzBuaigSvljlA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fc055bab76b532d5026f3e85c09ee362ce7437a83a64431600fd0eca2096d3a1\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e002332.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e002332.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002332\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002332\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002332\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}