{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002245fxXt57TF5fWg+MrUPYEh4P2DzAbOLwNuWPCuQLBNByNv1OtPlxcIAUhbUzGpRiMaMv3E3bdshyckYtxG2WEqGYvVe6XjYLav6FrMzFnxHHJ2O3k4jqEzOWq4QMfvOWquOuthZvkGKAnBNdkfvbFHzTRHSmzMaOapwWYqnBBCiT4UCUOm+kDduRMdsMc293epElUvt7EeMaaWFaN\\\\\\\\\\\\\\\/Ok1Ml0g48qaygqgqXiYwwSmrb20ysGHUJetZiV3w4yIGdZPu+k7U4Y+An+xid3Ms\\\\\\\\\\\\\\\/cNHFRKphRCCdl91EDUeyC0Ea0MjddZN3xaGhmB0jpUuS0mxvyFn9eCgLz\\\\\\\\\\\\\\\/uh10D2OcjEBK3VM02kSTZPM1seqLgLd7VFD7WibyazIoxXOlFD\\\\\\\\\\\\\\\/N3B1zCJtx5d7pfw4EVsvnPrtZ\\\\\\\\\\\\\\\/2z\\\\\\\\\\\\\\\/7frGsZ3LGaDsD1ep7u\\\\\\\\\\\\\\\/bTuP4sWFT5MDddv4ZS7afRcNILr2PqdlUTxsshHpaY0N4VZPBjjpyHePK\\\\\\\\\\\\\\\/suBV4syHvEKaZnD0un2QHdTebIegW9OGUkuoAXR76ASfDYqTi0tO2IRYY42D5G\\\\\\\\\\\\\\\/+v\\\\\\\\\\\\\\\/JkZkZ9isa6WQ1eQ9TU17KCfplledf3jWuYjs8H6bFv2BClGA2b+XYczrc1kYYtiPVHEFy15fVwdUJaVgkM+UbB1fxisg\\\\\\\\\\\\\\\/Mr9mv5gwKEmIrTySXUmrbdW69yvrVy2H6KUHZ9Rs\\\\\\\\\\\\\\\/OSOymZzBRLJWxT1H2WETqDmwYEVH\\\\\\\\\\\\\\\/5vEbOnLHQRhl\\\\\\\\\\\\\\\/BrxE83wVy7DE7A+vTdH\\\\\\\\\\\\\\\/MO9klQDeKVQu6Xohmd0VST37SyrqzLUJ5UPKE90tJLXfKdu9icjyD+7ooPo\\\\\\\\\\\\\\\/8NaeavPhAHkd8PQ0SP\\\\\\\\\\\\\\\/EyHteL84l8PW2+9ShcgTJdqeKR4xVLmEpFgaZ30b+FpEq5zxMTk0depsjzjrB6s2MtnnKM\\\\\\\\\\\\\\\/G7WeHUkFxc70z4Eg72FEeqd2GhEJM0K+hXtuUs2RzugBjWWpRVmEHcQVlOf2SAjnqnMMo9wc8U\\\\\\\\\\\\\\\/IVpyIIFkB35FPJdS4bPwbud6PB1+rpyYVKKDSz61IHjf5tgg+SL6\\\\\\\\\\\\\\\/gFj32oFCYbdn7u3Am0akZTReXMrSB4dVI7r5ainMKzxT5fR28zrAeRVN7EowtAiuKzQ7V89uxHUMouYs6lBZfSIPFBbJjk5SdcfFPxhfVb1dHvnaq9h0M7pcRTUuIIYEG9IWSguZZr5qdHL\\\\\\\\\\\\\\\/ANl9pCUig81maihPSuiGzCyvfYb+VVS56eIQCzlcpvzCJrRILkcijjXpb5asT6IagnOOwXqqGZyZ8JH7yeTKiN3TQpyjwu9EoqMOIFUoeA9b+mALx6qYtFE15lWdR7veN5j8cKK+ASSN1rku21RY9bhGbY8jDqvAdZ084\\\\\\\\\\\\\\\/v+tVI0Rm8iH3WokUpmyv8gMkzk2QFkOaGoTffhnXg9SpZDVcjdtssS4IvsyGLm\\\\\\\\\\\\\\\/tUvEKnq+ZE4\\\\\\\\\\\\\\\/Kkf4+Ist7sW7mEv9+1S5tdIGRm8yrsFyEx6qvahtN4\\\\\\\\\\\\\\\/Ej\\\\\\\\\\\\\\\/i2kwlVDai5aMe43ZDdLojhFb0ZN4KCct0zC67QrYwU288ZyHDeLYtAvU4HFqmRwhT4XKjaXh70Q3SL0fsqjS+i2xh4ygBTYPra9rWcVQZ6cSqpWErP\\\\\\\\\\\\\\\/kjhh2nLHmky2STIoFZlSvCa7jJ52aR29zCWdIVX5+A508yIND\\\\\\\\\\\\\\\/tSaBXLQMqvfZK7cDQGDReKMeY+LHeu3RRjzYCcJEadRAPiJvxGuH6cxvEIqzUexV\\\\\\\\\\\\\\\/mKDFmtR+xSd+CiehbF75dbvo2CYzhSnTPc16nD2ujdfQNqXrfe9ZDr7jxmjL+GaYhCG+eg2nmsUcgGZrHBHp\\\\\\\\\\\\\\\/QQ\\\\\\\\\\\\\\\/tnlsZUqSKBe62EZW1xgH+bhWZPtztoTfAH+cC\\\\\\\\\\\\\\\/YRVaxflMVClXx0OgY\\\\\\\\\\\\\\\/SrukMVYTadcIuKJUjPDve9bB8ZOpgyjJSBsE\\\\\\\\\\\\\\\/IR3paoK4Aqw0g0rj+09depepIceTipPwVTz+Xo02gR876xgp96gwdjYJ\\\\\\\\\\\\\\\/aawQ050m6lp6+ciF+LdfSnHIIWe8dZhC9lK8ievdrb1DlnR6RvxR6jVp3cAdRUfUlfwFWSL5uT39zUTJe1R4rPtYd4izltAwVtck3+QaswPrdAQ62YnAuvGfGwzYiBbnnHwZ1nFEZndKHkMVstN04s9O5tvXxGm7AnvIvkBvUN10KepZ9KH4idcckOkzlENLH769WYMQ\\\\\\\\\\\\\\\/kvwjQ\\\\\\\\\\\\\\\/tdiADx6\\\\\\\\\\\\\\\/jjq+Bh9wxLTjp+Qb0O\\\\\\\\\\\\\\\/T31bzAlfBWs22QLhqKCO+IGu5Kx+\\\\\\\\\\\\\\\/E5asl+HuWcS2lzZXzZndcczItnVsiKA9cSNUHZvxrsTunVdgXVLweyXe49GYEkNDU\\\\\\\\\\\\\\\/h50\\\\\\\\\\\\\\\/hMzJPa61ijDj0CRflMynSEJWpXH92fT4lVBur7Gle4ymE0JXZi9Yoj5aXtF19dOVH7OhJDEojUt7MW7we2HX+mc1maESH0\\\\\\\\\\\\\\\/xPsAPQWTLWBypH1ZSjLxqMOsjjxdFUlQMiyLAfhZfwPCyAyPMm2LPcuDRaj+pUuBxk2VCvs7crIi3nvADxRPJfd4twqt6XIEFbeOmga4BNHJMWjOMI+kYkL0yXWt375WGNqgS6BZj8R9Q7mCguqWDSzpPgdaTIT\\\\\\\\\\\\\\\/P8zp7mMa\\\\\\\\\\\\\\\/dqieK0v\\\\\\\\\\\\\\\/Nm7sAVYDwwSTVdxzdgyS\\\\\\\\\\\\\\\/hxJS1br+R2fsiyBjWiMPNoZTyJyH26tdu+bVXWgKpqwL9kGk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022wX17t2wtcVhirPTXKpTmFQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022460e5dea5b0c9d804893efe0bd2b0819ea1a23e2f7cd289773ced1eccd58055e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002840.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002840.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002840\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002840\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002840\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}