{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022mSw24wBH8tRb054wqR5O13G+\\\\\\\\\\\\\\\/PAwN6pCQFzCcpXu2dB5zlLFmKkhSQQrEOwDCFolXecf1UYb5ww72L5pgWAYzkRKY3vxRqsRL\\\\\\\\\\\\\\\/EHaYbK\\\\\\\\\\\\\\\/HE9PhyhhSBxitITV6dzhV94NWVaK76rhGN57r7SwIDymFZc+9xnQx8Fle6ZP\\\\\\\\\\\\\\\/OENFJbL3hKCamBy5v9uxx2MjRwOlca5eWUlRqlSB0mbemvIdK46U4ibf3SWK1uuQsj7oyD7yMvXucZSvjHgT2CYlgf9NAfjKJDeO+H3o0UyetrM14vdQDpHY8KcP6\\\\\\\\\\\\\\\/vrDFRZuRHPLnsXELohGoQrjCAcgS2\\\\\\\\\\\\\\\/wHV6qsx5y+eL\\\\\\\\\\\\\\\/OgS3Kr0ArphXWRABVhqQGM9GiAZQqoc3+\\\\\\\\\\\\\\\/ZQWvkc7HrPv2disuIx3iePaEFF7xloTDtISLw4gDTYWCJ2flKNFRknrZSaneOsOcEnAW\\\\\\\\\\\\\\\/mjJqRo4RNEfKBDjwM12LLBzPHWYYqQhAZ3BzGj6jHEyvBG7tTghzhUdr5InVqY1LU0jLvTqyybBKrCMIulHpgPzxKivTN\\\\\\\\\\\\\\\/nYkyZWoMN1MqWaFRM53tRMpQD8MZGKbHNGTB2I27k9uNgmNbMaurnH6CiuB\\\\\\\\\\\\\\\/g5wv0uM9vbGe3ci+B9oIIrNwecnvPwKMB1MBxQiyLcPfaIgtx1H\\\\\\\\\\\\\\\/1G+rC+9rhBJAp7A0tvo3BLjp+N9jDbLkTmlJLxIHppiAmhEi2hS+LZJdN\\\\\\\\\\\\\\\/3kIcVZa9Yedww2ZARmFS4kLMm5AyOdd0xR9eTuxqX3\\\\\\\\\\\\\\\/5zPTKgoKLq4wPPoKThUS50LHS32hTwSz\\\\\\\\\\\\\\\/SPwIrLd4Hyyj3raeFqg1si50frLSqVE8+PrBiJVHGpubgTsvGuocKl9xxKBQ8tmD2yhOj7iBguQNnnOoaRVezrk5phmAS2eo2uMHt39Mhui8URkXlEiyW3qZMkiFtHj\\\\\\\\\\\\\\\/C\\\\\\\\\\\\\\\/WOsfMAUrd7L3+WY62IIMwZ1STj9C725jXSaQKUAdrguEhf6YE0WCuppzJx2cF8Ig4+FxAFNd2eIvNtJ02l3hxOvzv6L+YhuZ8uygpbMrY\\\\\\\\\\\\\\\/XJmyh8BKeawwtofx3GUpCL4D86PhWQbMw01M7K6Zu3cCprSkbSiGGHxj9JhHCiHBTHWsCle9AGEiHVZrrnHkGFSoe+G6IuRAbe95pGS6LfYKdg7++91q4\\\\\\\\\\\\\\\/C0c8tUbr9Seg4824dBXaQoxzvY4ZAEKUyqW2qb5e3OSHX0ANL73PQHbkfvJNudQjiO7vj8QaAB7CsqXSktR2vbMxV86MUHTns2W95p7OrtlzwpRnljaxdH\\\\\\\\\\\\\\\/VpfIF9Seefw7TfiLuizfj8BhG2FYy1ZMoFOvM\\\\\\\\\\\\\\\/mliJjhz5L\\\\\\\\\\\\\\\/pKY6IvcImoa7R4xKlW7kiDwzwqtOYl5S\\\\\\\\\\\\\\\/BkrNjLV3RoTlJZnBoSuxMHdR1DXtxbIFcrAbhKxQhWknUZ1hzC77c9RkEvMnzU0lKfJD5TNtn3goOOojA6KZ2TN5nt90WR0fJ8Z9sdr9KoZzE9MMP3w5lbTFKomXurvZ9UkDswKWVpKuwIcVE8WRZVK6krX6uT0YJH9+b5j3f0dfSejLpB1OtuFKmxOx1yQEsvt7WYIxdN6+2ZKWyAMqD6wnJSK74FINIjMlX3ES6hOd0Itg58jIY9wlT01e8JdFIS5Q54yXPM5\\\\\\\\\\\\\\\/JbND4GwMk9Yr6wCaKfnoVcwCDluQ36dne6B+4ee2J2wJvTzMJJhjndTmGTtcR3w14gJT0sJfvVawTjYMqo7aH+s8FFC1zLe4e8rFUxFH\\\\\\\\\\\\\\\/WtF0W1Ry2n7eo3HuGwbcYZURuJ0MxxJefCkZXet2Lz9OhA+WKEC8aZrgTl7+XvCUognd6fS+4WcqGdl3LmpE7eV7DvlnYetQ3NppUMFgOYqcPirGH8NHMK\\\\\\\\\\\\\\\/vAsvft5GuR5IMkkzeSHVRYFI6jQNFHQ0OffKwa\\\\\\\\\\\\\\\/6rv1dWRONeTnVZFw+6tG3VDTwfw5jUgKfLMljElSFMFL2uFT\\\\\\\\\\\\\\\/AEw2RdNxgfl2JNRw4V29Jw8UtSj+lz\\\\\\\\\\\\\\\/JiVhl2Hh2h+DYQJSedumoTp0Uo5vFJcBiGWPYR0Lj\\\\\\\\\\\\\\\/4nyPs6nRJdYrCMlS4ZCj9wqxLQcWAmHjrVLyMr\\\\\\\\\\\\\\\/xdlbMang15QpmhfE\\\\\\\\\\\\\\\/n1bTRsyEnPCIIqTt29kE6LBzBF9P1s1N3clPJe3eXarvHuKEXfxBw4U+g0r\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/h+1zAobZz8rzoEdQ+yBzifcAQHWvQT39+iPhchqU8RJFrbJcVfXpbwTkMa0QKJpxMUOsYAptA7s2xzURAbCwqFcDcG2FrwixGbWJyDADfFRGhSxRqPvIxEak5bIFr2u4op5ktPbl2L00y\\\\\\\\\\\\\\\/MMkD4LaVpAwlyNoXbSgCweI\\\\\\\\\\\\\\\/UcvFiANQCeKRzKw+Qe3aEEL8DO7MU5rh42De16HxPJTyN0Ngfg2MWHWhhnOhUVtlEOfbcJaBrSWpgicvZrItAr3jmI0+Wby+j5WCrhL19XL5kLZ\\\\\\\\\\\\\\\/DTLcLxdqowJf6rlG50BO+iewoqnt0u\\\\\\\\\\\\\\\/xM8yaR1pn7hIGpZ0R313fFZSCc1Hxy2lfdzwULZ7Z2s\\\\\\\\\\\\\\\/+t1F8\\\\\\\\\\\\\\\/tsoYQiBjrLHy9Qqq1+Gu4TVMWb5aqNngbKo1w\\\\\\\\\\\\\\\/Lei6lDTmmISU4NoCBtTNMTRyNh9y\\\\\\\\\\\\\\\/CP1M023TgbNZFfmrT8ovcfTugk6iIjhmKuXNupQWUOFwpbi+pkivkvVETa7q\\\\\\\\\\\\\\\/nDKTdi6I4lSt3E=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022kdVoNhEtDkZEXIutghnpYw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002269d4336941478d3eb8a17e0f1fc57571bb8139a42f9b4f870784fc2b9502fd0a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002968.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002968.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002968\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002968\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002968\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}