{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00223Ru+jvuvXulxd5XZ5YOOJsozF5Rsv0AiRaC50a563OOsdyhsy7+lUCYs5iZxJE9tggtt+mu1DQGLgNJRANZv\\\\\\\\\\\\\\\/YoCCiVdoawfaZcyRz9oQ70L8fI3ajx65F\\\\\\\\\\\\\\\/Q+5gJR6JakYs2iZs1bMRu45x98uE8mHIFCPe4g17UhmeE+tL+FyTeh\\\\\\\\\\\\\\\/YJ8kuw9QD7X1+JCC3+ep2\\\\\\\\\\\\\\\/UscyxeZ8Lz\\\\\\\\\\\\\\\/hlEA7kIX6BgGmUQjjx5xG5hGwFga7Mk2Z7rw13X4pU1DdyxFEiNx114Fa5opepSxVOe2ChxZpaBSj8gnVKt3RpOrvwFJQ+kiq5CgKO1Jc2XxI+H8y1h40N88aRfUCci3\\\\\\\\\\\\\\\/0o5mA1BeKXKHGxMOcvU6C\\\\\\\\\\\\\\\/m\\\\\\\\\\\\\\\/XlDXh\\\\\\\\\\\\\\\/Fo\\\\\\\\\\\\\\\/w4RDQwrVA+oa97pqNr3L3itBsCtOuxhot+KtXnpgo67fNVNXc7C+xnQtVxVtHE008cHLO9+aAtwgaz9fww2ITZq0Mz4Owbhs6E+9Kt\\\\\\\\\\\\\\\/74RFtygV1jthnk7tQLgnXZpMRlGdSbzk8wWw8M0tqROmLsORLZawo3ZkfnnfiqpxBP4aOGOue0O4R9KNQCQ9IoKUayw+VyWLTBYuNxGzUrAAOn8IG56OLrj\\\\\\\\\\\\\\\/1KYHdeEYJfX3NLt5dzFe1DMc4dBU3ooEif277C+yrBjQfm9jlAy+TUBX0N6TrtsCbGpodBg1qxJtR0uZ5\\\\\\\\\\\\\\\/IBt0NRjYaUOHeMj51+TlwKVtAXpAOrOHrY2Hu4DWDkY7n7GWjHvXcDW5U5p9MIwfg2reGcOy0q6fKCncQKqYYIdUsnUzN\\\\\\\\\\\\\\\/r7jatNNTgDKZDEQmD0eDxvvFiJwLGuB8cBTo23q4HCKKCx5oLQdt8XDp4HgT7e1fo7eIsZxt51ZgbrGK3vbTn+uJuR5Oj9kof2\\\\\\\\\\\\\\\/FFHte80VxWraS8AShiR6fUUu87p6EM9cJWWd0v2SwqlGF10wzytaJNPxp9+QPvp9kdZpxO1qpWVlfNAbPXjmqzvYRQLcbFoXbC1BTdEI+XuOYaBOluQk3\\\\\\\\\\\\\\\/UAjA3\\\\\\\\\\\\\\\/I3hbTqtmAExGKuMEnunhfT1Nu8X72ehYLqHsx51QhHDV5kwsB09LEN0i0gWM6TmXVBy437uTNt0SX8f0hXEJq6sZKRC6Q3x2jfLVAFlgvvAoaTLdW3QtSZU633FNJWvtN9V1jYNrqusUE2PSD0YWP4LlH8RY58Wa7gkiW+un+ls0XrIcjhVEKe3v1cWjZfGREW\\\\\\\\\\\\\\\/C7bxNy5h3emB+3HjLMBZxQnpRiajdvXK\\\\\\\\\\\\\\\/TlSoEQwHVrV3WgQRRoqSmYqQdG2eRkRfdoXzFkPE+iE6Q\\\\\\\\\\\\\\\/bonUJU077jIIRqll4MlW\\\\\\\\\\\\\\\/q1Ev5x+kErGeODKBabYHG9towdN2UNovuGZF397OrdqWNTp8UjBvMFMszCR2UBseuwygMBuyA7GOSTfisXi4eAL9jeaE4VhvIqbzgQcZ8trkRgg+uxRldRBzSTKORM5RecZC2hH1F0e3EdURu73rS28WHoDGzTcxkzFb78S8kMWAA4O8d0fXbxtEF6rx\\\\\\\\\\\\\\\/BqWljTUQ\\\\\\\\\\\\\\\/crtK6TAva7B7nbbg0ASpnsQI21dcd0kTxK2PzVwVvmJeVw6zwkvITHJWg\\\\\\\\\\\\\\\/7GdoQZmVigc5sG8THPTZJaDNz6\\\\\\\\\\\\\\\/+aVl3IGDfLnIPdouhlsQOMxQOzic3DuRRPd9a4zAyJcWsLm6B1CPRRuheqDFpYqm5zvIQDvlAHeSxET\\\\\\\\\\\\\\\/vssONN0UG8OViIzLocXXvbob88gjHkvjjKPM+opWWhGaEia2YuSeyQe\\\\\\\\\\\\\\\/pKK1qaamUfUKNH4eKcBqbqwXwxpFcmEanQ+5MnPskWBJlHGOS24xb0R0oW37pZCDvRFTsxMZXDVRLajZqiex24jYiogmxkaosXd5A9yqJetOToCBVPR\\\\\\\\\\\\\\\/S5Do66ektRLXXoiWbxT++GVDMW4tq4EsyrMCxBr0t\\\\\\\\\\\\\\\/MJ1AsfkO5bvXMTbOhwaFzrcydUlwy+iPYcPXx9AveIXqfwiAUL\\\\\\\\\\\\\\\/ptIixyTwA3ghP15UkZaYnr9vJj89EsHjZg56vjAJINxM4ugmef\\\\\\\\\\\\\\\/VP6DoNBhU7oJYN80U+PUhRUar0rteb8qOSH4EZw8mxS4lXfQSaU1LEd77+a7iQPuAmpyr1SqXScU8yRKZv6bGXJyo1X5G45m8DUipgfbkEsOGB2q9vuWJaVePLIsZjH4JfgIZl5V9s6aSfZQXSwFiPlNM81XnVHunNCz6hrN63zCjmR7HCVCCJ6iBAgtjXRjGuhyHPbYrQuVijKNdP9ONXlmskHTnsWuVc5FmtcwCZwthcmPkdhxQVDu4DSl7kg6O7DFfuebFgyzykXuS3IvKQS+MfLuaYI1hZsP0OFE7m93XLfGVa1qPL9S\\\\\\\\\\\\\\\/OIvtEyoFtEU5i6s4YzokcI+U6jQaO0BTlvw0srDPxMkhW8YXKesv0Hk9ekq8Iex0iFyCmfXx3CcwJVtxQzbsi9oaUWo3eC4fm0jxUDeQ7M0mmo\\\\\\\\\\\\\\\/qtt3E08UIujBHajADIcmLqNlC3oInOEArw6m3SjkvkSvGMK4Tw5EQTxeCA3QnG0acDn4j8Gh61FU\\\\\\\\\\\\\\\/8SDsGAnsBMTNdbou\\\\\\\\\\\\\\\/0e8s38x56e39eGM4hRB3tPsEWP2zKC277c5vH6l3dcpjXFsgDcmNHGQlPqtwZ94mHjZHacHafFxu+LItwnyMay6TH7DcSplWO0TK9zE1Z+VcJnvr5kqCr9Ns=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022U5niGxHk\\\\\\\\\\\\\\\/2ZztcC1BEOT0Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222f85fae0baa127d5cb014b98a200e2b850d1ab186201c8c74a11862627515a75\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002850.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002850.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002850\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002850\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002850\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}