{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022460B5OdY762CLlSvGZdVdqRwo\\\\\\\\\\\\\\\/0hvkMhA\\\\\\\\\\\\\\\/lPySnBcg+Z1ePmzla+D5Zd0XohGmKatnZ6e1fV1jFdDINYjbHxIZOqHvazDKQloU9+R5ElnqKnt3sTvf2LcnO6o7ujXsKnZyiR3a9v4RcvBvDO1RCuj9+y8\\\\\\\\\\\\\\\/qmn829LDHNfMB5OVtBKrvm21jnygPQN6i9po1+U2S8DyU3kWkD1O1oLL87oBBdQ4fql2ntCwlibKFPO\\\\\\\\\\\\\\\/eoj2gCtPQlDVgi6SigVh4SMwi4o+fR1E1kF\\\\\\\\\\\\\\\/TqIG1JO3sRw9ps17PyWdn66rQbZVz0QG22wotUZ9aLDC+b4y36x7VQfY+0R++RbvEDhW81HWZeVJdIx6C+4JVC09BEW4c0HDhnqPimap816006B0WkkEJVmgtNIfj5\\\\\\\\\\\\\\\/Jw8uHHwU89BJS3LLjd1bMyHHPk9p3PivAEoWKoh0xZaep3KX77IrJsA96gDyHSaeNASK1x309ucUEgrGfxc5QomQaouwWv\\\\\\\\\\\\\\\/DoiLvPXeD8pr6Twy8Fh01X1uFJnaIvO5LKS+4Pnq9SuDVsWgCvKGiAIDOyZ69ppIJed4kAGehyesvj8uJOxg7+wjW9u9mn3eqKuxXR9k7KlN5++qiA4rf4LTAqJEx6LuG+9sZTEKbn1uVWuef27NcWbul4GiZhTWYM4oIITL\\\\\\\\\\\\\\\/CZbq7PQq8GKdQ3l9A998\\\\\\\\\\\\\\\/8ZrklJIgtcyjH6yLash\\\\\\\\\\\\\\\/sckdKQGO4PZc7Eu\\\\\\\\\\\\\\\/N3Fa00Qy2EDDZbTmhi+1hryw8vFUHuhEpc\\\\\\\\\\\\\\\/h3\\\\\\\\\\\\\\\/fWFn1srAxC0X7uAgrav\\\\\\\\\\\\\\\/5F7wtCf7LvdjKIfVMFhv9fokRvTni0nDmaUVndx4Uffvo3r5I19nuHORBYdeEdwLQ3ii2u8P7NyMbS\\\\\\\\\\\\\\\/J3P09AITyjtL1XlC26nclqTK5QrARBCVTeUtZO4w2IQdU7YmfcLYABWUXdahdT\\\\\\\\\\\\\\\/mOgKIMNkNA3x7G4eRwIXZHDlZyh4mIOmXsJ1oa9ja10FqG2K9vL\\\\\\\\\\\\\\\/bGC5kZPU4yeKhTAuqzNkzVIQboQrUbOTX86AzssxCZivtUU8ayxTuhPUYTvMwJsTo3xnYRMVlBvral3xOzj+NQupjsQkpjM7OD5GKK4TnvJLE9GO2+mVlR+lKPbwRKbUU6Z39mLHXXFIVKOnaSyW38ys9F4kH8nP0ThXTCeoFVhdSMPSFPPCUfQl+9Lr8jWs0YXkUhu7XXaJwHcvGuYZyuUprigUH7Hb05TBg7rsQmBRxQG3P395y+\\\\\\\\\\\\\\\/Aw6xg5PSMT\\\\\\\\\\\\\\\/WuCTYNqKz9ipOi+2T3JEhPfzBlvtyVR5GRnX7VoVvzYRMK6v8WJAuAxPZ6EtmukTQQmNio4dFZTpWOzV\\\\\\\\\\\\\\\/C1grTco5Ej6vIBTBpaj2Fj0j0j836eCXMoX8eOdWwjKhOjJEm+7U\\\\\\\\\\\\\\\/mq6XrG7kT14\\\\\\\\\\\\\\\/RF+xVl4Ujw\\\\\\\\\\\\\\\/SvfayqWw9NmsS5C2UAI2Q1zKaWLEqX5nodZrbi80\\\\\\\\\\\\\\\/IB5Tlg\\\\\\\\\\\\\\\/4mQJg3rI4Zqbb0xlyDKdZFSBzq+PQi5M79H9FVbDFXS5QFnm3Vq\\\\\\\\\\\\\\\/tNrjzrs79cxt3V2qEwIhOBmXwYJQu+pB1xn6F3Oz4UjubJLYKYzB3OEY7RD2lgePnv076Kw8VXXJFlTQTL1wqGOMe3rHNGHiUEeAJs7BikKdXcIWdmPK\\\\\\\\\\\\\\\/u76gFgAMspRPuaV7inSq\\\\\\\\\\\\\\\/HRtkxjaAF8mqOOYDKQhUfWAwy6YkHVAjTFu3ngLOWGuqNTojj239tWhXEghI5a91w7txdacp1W+oNn0FQ0gXKgB6QCJtiQZzBE53gki2D\\\\\\\\\\\\\\\/X7QAycR5U7J3HqzFqOu07Q8KxdV0dNslWGrRfgddxPrHAvHMrYEiQ6m0hvnnpmUVPQnDkBeSdFe9SUGSX54TRsZCZWQ2GLeYwqXSci1lsBmam9579pFkpU2ak4d7sMRyOaH102jFY7E1jvF+Vs9ooTCksfTWLmMy\\\\\\\\\\\\\\\/POiwCnIoMybCVjceHMCxcUxyCnFZXag\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/nWl7kUTOlGrY5l8wI0nQ13dG1TAQCIKmBoH2Ydu0EJJ7F8gOA3\\\\\\\\\\\\\\\/IH3e87ZXAZzGNOYgo3u2T6oB7jhCZbr1B5zTweJlJClzdYmlUWtEzzwavVPl74o4Y6pxgv5VGfyfRT7W2MX\\\\\\\\\\\\\\\/SbCMwrsXZrvlr6I2IlZtpww4q8Uj\\\\\\\\\\\\\\\/IlUcJCsBDUKI3CaWETV0\\\\\\\\\\\\\\\/2OSL1+P0xBp7R9qPOSDcWhFryPLrbu+tX+aW863D8Miv3ATmFVM0WpYKkari0fGrsn9M82SNc0+vSKuioJJP4tFeJTKxPEg2LOuLnX1YKojx7aD8OFIKi2aSPm12IwMWz9ZqqY+ZF6D18m3jBud6QUdA5uOcAKhJdp5dGmOMYtZbHBJya\\\\\\\\\\\\\\\/hbV\\\\\\\\\\\\\\\/XZORG\\\\\\\\\\\\\\\/fpvuoC4tWuAjF5cjOYfnrpq1Bhuz03poe3ebzlUdvZqBCyEhNNvqQlilVu2lMd9k8e2MlgnizGn0w80a8HAT2R3ONE+jw0OOdOlIIStIWVbo5nMS5YbFYyZyJrJ9FoQxqHUIYnSPzavvV\\\\\\\\\\\\\\\/qTRchh5cwO+Ih9MWYWCPLR52zI\\\\\\\\\\\\\\\/LPVmKcIhRoz2UQ6REwGyDGHxSXbjeNfxYvxu+cSdwfd+K92V1a6bhPTrNIYRVXm7Mcc9j4HDIV\\\\\\\\\\\\\\\/aVWWyFQx6eLRdr423nFx0JOT7dzQY9TRxDCQvVAhxW\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/sOK01UmQHZWp0cbSqzE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022J1LWVNobwQb3HS82V9OQ4g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222d23ce4f8ddeca4d6d52fd9ecdd664d90c610aadb96e542688d7438221c0cbb2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e003212.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e003212.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003212\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003212\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003212\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}