{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229wz7eJS0ZCAmIZqa06sjCpLGqNp+YlTgHQCY7eM1Ixebe1T5llTWPZ9wFPSTY1TwY7t5vx0VSOJ6Mv0NKLpf9hQ\\\\\\\\\\\\\\\/kDjyCcAUNga59uHEqy22qyzNkWks02xbP6Sv+ar0R0g6xWs3kydibduyW56DEfoX4ab7lVs9Q5FiBBMYjzVGN3Ev\\\\\\\\\\\\\\\/tEG3NJ16TS9AXxiFiLXoc4Gu83Z2\\\\\\\\\\\\\\\/ja+7KfJWTzu8BGUvx2he3m7cqCCyEF7n3963A4O4Td+gU5a72vvvoc\\\\\\\\\\\\\\\/16P8G\\\\\\\\\\\\\\\/3GG\\\\\\\\\\\\\\\/OkLj8MW3CPujox2LEpQeO4IvB2nWtWhU2D\\\\\\\\\\\\\\\/4rdlQ9q6G6HqIbCnhPwPKbWAonsRNKo7sQcxFQ4ruEpPljYdPlZ6cQwaNpY0EbBWEtzVHD8Ce4wRJKWrn91SgYYdAY6TPi57NBbcVlugWc\\\\\\\\\\\\\\\/PDrAhjrxXNWyUnSZBAV3\\\\\\\\\\\\\\\/gfAu2vpekRgy0ehtRzNRc7dyWaScT8PNaDz2T22qc\\\\\\\\\\\\\\\/ITJl1OmTOm49D6rD4K6PjyQJrx+CwSEn9g+Hc3Uw4vr8QGEOkPaHLTR8ejwqFHiZxUyEK9hZzl52eZBuAgrIePxisXKRhq9SG0bXkyarf71xxgxe6p5a9sIJoiP8g3aa1WnKLf1KGtAEYg1lE3Oyal1U9J7bQFBplpjR\\\\\\\\\\\\\\\/GCgwPcN8YPA9Rzm6Z2PqVro9EaI0OQWAhMhPXVd2bpuzbGPKO\\\\\\\\\\\\\\\/iNuMkGPy8+UZvWoe3pK6N0CsRlCxm5ecjc364Ij35aIIBKKIwDahg+OZP1P2ZrS8nkJ49ZikmqN+fzUCz4uzQCmycCaV8gvOElLXtClPKakSYU5FX+0oHkRp2RwAhM5kauev7lwoz6j3a9V98DbqEH7B41o8DnMNAHzu8LAkLjchCaTYf\\\\\\\\\\\\\\\/1lvWbCjUdYUhsaZv\\\\\\\\\\\\\\\/O9fsRfm+E869wzSqsMVBhoSowiB1FgZhF8DA1\\\\\\\\\\\\\\\/YVlSmma\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/NCEIYaMQioAaZqMdM5NmTfZ7J1FoWeoKFST2fsWQhNeczS7h6HXze4m\\\\\\\\\\\\\\\/FTbS0ApBYNQYuly8XnpxIOL+3w\\\\\\\\\\\\\\\/i8Jr4W5kjQARm73aNs3rTRx1lheWeBjXxtDrPLZn29w2adl3akHKeT9vx8Bz\\\\\\\\\\\\\\\/VvC8v9p9eQpZlqcnIOpDlqq64hpla06Te\\\\\\\\\\\\\\\/ueWHFIiKwTlTqII7rNK2jzXEi9aX9SDq4nLBbHj5R0hRBTQOmQCCIpaVzc+SY9eYkKW8T0KeeaKqN0Fxw\\\\\\\\\\\\\\\/+bp9li0PKcf3+T3ZtRMZ+LmgCS3GgdGVZlP766yqPRoS8jkbA6Js6Y81h4y2Q48Vm9CGYxDRBQ6wtTZ4OxS904R6LoRkwMLldLFtbZh1f7AD+BycpEU1BIfriRd8EG8an\\\\\\\\\\\\\\\/MpH6qme+gV\\\\\\\\\\\\\\\/5wMZvSoJqYE1gSyZ93d9UcmRouOVZHgIrqzyRQx9PcR58Xl8W\\\\\\\\\\\\\\\/LQvyKRhrM4FuqXuLSVsxDf56VAmP8fXqideBtV23GM2kkNLOhOc1F6K1HU5AFKVu\\\\\\\\\\\\\\\/uwX\\\\\\\\\\\\\\\/zy1sfMRrs8C2LBjXLC1WQnIf1b3LmgpKQpwcB4Vqa9tVw1NB2Lig18YGlMWv9KJGV4jFUzEeSSoso1susL6bkMZwrZs3w1SNFXy2oB3ZbMOFVp+hX3Yp8r+raEy2D0O6KNqHKIFk0He9VKlM\\\\\\\\\\\\\\\/Y7+O5GmL68Vdp9iN4REt\\\\\\\\\\\\\\\/qnFUoSeMf7xzvjk7FNgGBMrYKmfUd+DM6+m\\\\\\\\\\\\\\\/FknfUJhGfKbWU4Uqq8BkO\\\\\\\\\\\\\\\/KVn5ReycZw\\\\\\\\\\\\\\\/29bZodDKcNNmEinU0MnNydMzoQ4VO8f40FXB3w5EUCLR0zmMZ9KPOCNBvb8H8yPAG25k2PrMTV01C+NmQkynd7k4Mbj5IzlMPs9OhFecVxviQ0h8w5OOH+S+\\\\\\\\\\\\\\\/Y0xoe8L4X01Iyk36y\\\\\\\\\\\\\\\/eWGOWK\\\\\\\\\\\\\\\/Vw9\\\\\\\\\\\\\\\/Kgf3IPL0G6lLuQ77GyC\\\\\\\\\\\\\\\/oa\\\\\\\\\\\\\\\/nmW\\\\\\\\\\\\\\\/sOAVbIkUks07TucFxZ5F2kR6Ix6z22liG5Tww0GMXr4CAPGFPwrJvcJUAy4at2lLDDotISweOoxeO0BfiIctfbjbI5YOtdbN9GzK\\\\\\\\\\\\\\\/LrT7Oc8rOqkJ47LHwVsdNrjC\\\\\\\\\\\\\\\/+uVqRvOQpTjQx5Fl7jUP1OMtqGAiGQF5EQBE4FAkadcLzlyalOXStGJgq7xSUqtycmO1f63U\\\\\\\\\\\\\\\/BlsJAF5jW3Y6vaEHuyouqruB0lWia74lw03p2i+c\\\\\\\\\\\\\\\/aSCeHd4AQvsLdpRoKuoXE6p5Fq7++2Krp5OLxxkCl24n16DAzcWOaRW+UHaGsKnImsYfRmDCZrOcs8\\\\\\\\\\\\\\\/Nzejwiz6NQtgWArVMD0ddiJxROwhLWvz2+vYOhlSemMHn43NDqaiA4Ckob8wrUMQsLefLcI8TalWwh1Ixm7VhG5yb\\\\\\\\\\\\\\\/N7LtkRsNChCL6Q+ibxYmKIcDplVWAddr+eWsR4ht1yPI\\\\\\\\\\\\\\\/UjbfKSqiG4iaFR7PqvjyzEpLVPeNgm05nwtMQiHfdmds2oWEoEnBkzuuhot1r1s0KxrrzKsDmCuarGLoPsqlC384Nz8w6a63XNkcgc+tc7S3ht2fm0QWvlG4\\\\\\\\\\\\\\\/Co1nh+CqBRaxTyY+PcAWI4iA6NRmDMWn6hi4sHrJtq9PGLdyLPe4LamQhoKbzx3MVwF3Lr3W1jf3FkhLdgnGVZfgVq2JkPy2xHdLRCduoFmOoEcEIt7ILEIXnNA7Pm\\\\\\\\\\\\\\\/i8w5Vd+GI8Bj+um1FhtNvW5AhjQExFEAv+C4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022mtXlXpJ84WpycJy+ox5MhA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022972bdcae7bf2d79c0a760aec1119080eedcc04e94beff781807cd08bd8088ae2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e003044.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e003044.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003044\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003044\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003044\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}