{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022iqdk57G3lAfqECg1QLO+OAZwUDojZa35rN7YFB9TpbGJ4aon9VkfHcMtPCEX7t8UEWf9zyJ5U5FWPreRZOvXy6IALrZkXhd+9cBIZ2TDhHAVGIut3p0\\\\\\\\\\\\\\\/fwu9NY8dO8s\\\\\\\\\\\\\\\/wY790y2Mvfg6vxLgQ3AMSE3XmGVHec7CfKjVL+bz9Zfqx4ejagJqrCxCQnncIEzcDMuy4JJ32VqrhgL1SfDnxx0gDYblcAV9hjIaVBLN06aAG7vWWC8Q4+23UubE60R+FZBVsz0pFBoXYcIjWRZ1+QS5RNZXtVQE8Rz8Ym5+LVN3mA9Rj26A\\\\\\\\\\\\\\\/Ym1vCHsQIpDo2QVrwRDEitDx8CJNvZNH7\\\\\\\\\\\\\\\/nrU34megiVxIuTVgHQ13se6TT1ed476InxfPLksiDi8WaKJyhK\\\\\\\\\\\\\\\/Vl\\\\\\\\\\\\\\\/wVksFpSgBZLMaxqWKHaDRnxccU\\\\\\\\\\\\\\\/WrGnjjkSg8mbnsF+EjjnoUvoF0\\\\\\\\\\\\\\\/V1dUDgM21KOL+WUVvgW4lZ6C72aYO8O0MfIMCxNtpVncvmmoCkHdPXiD6\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/o7rlPBkFupZqAubhyN9tO18yj4XtAUSFehPScMdFuZ15GtPFEQQh0II2hygjAvvRkdyHujvb3zEOFm0kz+AE69RJ3csvw2yckBEAtbAGBF0LRe1+V2SvlhQw\\\\\\\\\\\\\\\/Dxd6lFW5bNjKzacQ7Q6ya9sGXOv+tgDJFZUM9qyLjU21Kdb\\\\\\\\\\\\\\\/L9LfAih8sQ9yfbmgtSKHFQN1b\\\\\\\\\\\\\\\/gl8BL4oeV1izHKZo7XVQnttLErB4RMa0VCTCBTapHMcXy5PLMkh1eJ7zt+hnaEFH6iLezAj9xLm3tMtnkh53mX5KF4dDo1CsBAO3s37ArrP3IEylV5rtr1zxnB5uzGMC7KzedtZcMxpTwm8YL3jwJFS8bNA75zpSBQNRVYtnsEWccxI95t3+HprC+Ce94Y6+73hwdKULjWtUpy0BxPvxCv5DKK2L2W2emVQYS8FIvpHcPZmxZ7vAvB7xYIn22Fy1F72BVeHNCKNUl2KVelh9xloELtV5PMfYtNGFh5ayRzmVUhNOTgfIIeSk9GYW80aeG80OakRT2+0I9Fbsg2pfQnE1lBOGW1UIr41clkhKVCyw9LcIVT34\\\\\\\\\\\\\\\/OYPFg4YgEtlj\\\\\\\\\\\\\\\/qS0+7RgoPY97Tuxz\\\\\\\\\\\\\\\/t4CEvwVZjU2MUFvL6r4qTZ8UjEArvbYw5z1Wyf8pF5Vk9VH6JtKr8ESl4OvHx3PMZmMrJZQaTIg2VD2u4+JUWrmGaQ3xpPPKVz8z7c5h8rg9HnYf7xn+Af3Oa4K7jCX3pndk4FZ0iYB8CAWlFYuXBYJZiSrno+BtZpJ2trfmiG+uC5DImToAMJIxQ3tG9j+SDGSOF2iAXLkyJgQxGP1ReUT6WigwWFCbeIe2oNkLGAwLE8snROblFUIclqgg7Zfs+p6ICeXseosXO1C76AuOSbdcMwCNCZQTvlSk9DFrnh2GUYo37NI84aE8O2LI\\\\\\\\\\\\\\\/c8mLiO71HeiSEv4gR8QspCsueYGtnURdLxomfmyCel\\\\\\\\\\\\\\\/m6ZZe1020\\\\\\\\\\\\\\\/WWwP3ByLKaxjOUeYcXUGLMP18IJHCX4mpjbiaLA6sv8C4iquAuzsLZ4JzpeY0yK+Y9h+pzIAimh6ylTauPm3TZkT4KKHJ0+KIbvNPiY9VM94igxtYu+ezkmf7LIbVOVvrXOvn\\\\\\\\\\\\\\\/iVNya4bQ\\\\\\\\\\\\\\\/fykU1PuSFw6LSikDmSqrEquD98Eh4TC7LQDvWh2u8zmQZ8+LrbGPMOk7Qs\\\\\\\\\\\\\\\/yfs6aM1+S\\\\\\\\\\\\\\\/QWoLOMN1CXv\\\\\\\\\\\\\\\/0jVILX9jV9L80cWyK2z9tUnzM7Lshfx4+VmwBp3r6W00rU9\\\\\\\\\\\\\\\/Xz9jwRAwylSmI0wHuy6aVWNsMmWD9jjh4XuZO\\\\\\\\\\\\\\\/jAlNOwHQjvzaLU+7wkGgSFKm2QwW+8LtnOVXLy3xz\\\\\\\\\\\\\\\/J8EGIyxQORJ8757NhuaxkC+iF2udPB+E6T2QdqfBymLf11dHPjT4GkQRAbnrk54p\\\\\\\\\\\\\\\/eirrr+53kLLCo1bw0f0Ukb1hyBf1qvKxD+cU0deCXBkNe5E+h\\\\\\\\\\\\\\\/aw6TFLiSr1cJTGyCEZ+XVSjp84bTmhH6KCMR3BBjq6mV7NrIZQLJwQnkplimxJCPKe56ikicDoEjBvXDCSHMfDSTqfxYdeL\\\\\\\\\\\\\\\/SWLoO+xa\\\\\\\\\\\\\\\/aGHjk5bRcgo4hYV2jNgo0yrmYKLYO0bILkq2PW\\\\\\\\\\\\\\\/2WrLxGyKB\\\\\\\\\\\\\\\/EkwSVOBrs1D6ybB3\\\\\\\\\\\\\\\/dfRt12t1Ue9jX3W+XRnk9eje8vCpdz\\\\\\\\\\\\\\\/x+5dE5eNh8ev7YTTbcLc5aDPJjUrrWnlBDVTTyvd3zyxVcf0QOOXrcnNVEuduR\\\\\\\\\\\\\\\/ugjk3sjtpb\\\\\\\\\\\\\\\/3uhkgXEmLnrnNW4F5m4KsBHhP9KNXJI7GXOCBygFbDCaqs5ecig6dbKp3XluF1wWkl+Um3EmEKiVmR\\\\\\\\\\\\\\\/Ap+SA2C9ihDVyVd45J5remdVbd6ZJdHvliHKA8tS4iGdkU\\\\\\\\\\\\\\\/BpyYAGr5VU7B4yKPhCl0vG7jJ4AsgK5AudaXWxB\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/PEVt8S6IGKJVC5BQ\\\\\\\\\\\\\\\/AT8mjCWeGbnQSXEfkutJ7GlDCbZeeEqD8UZq7YR5vDgtFsF4L6rdiZnkL9azNoekEuUC+8zQNyrVJfHdG8ZbbEeVC1DU3rsybd4uYpqixa1Yjp0zlHnZhZbX\\\\\\\\\\\\\\\/3YI5BDrGWjNsQT9BFqs2szSGtgjYDPK5BhUpc57FWpZrmuU6pFpT92kGO\\\\\\\\\\\\\\\/ybY3sVtB4GsvX+u0Rt4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022IKEs1M4Mt5\\\\\\\\\\\\\\\/VwbHjweNwVA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e232b702a810464bec04757bfa812ecb9e63856c807f466f16b841343540998e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002844.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002844.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002844\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002844\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002844\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}