{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022MRahHLP5k5qHECHKrjVutwb5XSNR4HxPao8ZD2cFLbjtAeDAefGRkmEmJjDV\\\\\\\\\\\\\\\/3T0eIuqOSP0OW5Pvpwj1ayd2b1jPjegQiWEOUD\\\\\\\\\\\\\\\/T1qYiPeUc463+rer2PhQ0o7vBBRiV3yfjHoWQa3YpLcOpGx\\\\\\\\\\\\\\\/NM9E8ZX0tdW52NdT4xoHbGRdjMI8l1SAOufZYWZkcLjMHfBQqmkL5GHuDv8m0tWagxLMs1dy5ZtzvWtgtXCHidjKwHzamkdYoJS6vPRTX9Y1bpKKDBGGP\\\\\\\\\\\\\\\/Xo5NtzM1E0oT+47TeA9BPoUubbYix3iWLYZd\\\\\\\\\\\\\\\/2v2WTDTys3oMvFxss7\\\\\\\\\\\\\\\/O8LBXf2sCDzXlUQlOZQDH7ZHKhzxUshV1DVesx8h6rk1zVTel32unnRm0cw2lJv0ZubrRzEaKqwpI56jfnArRvp+c9N3lOqmkx691gicmvHB9u7miNfOeQoDnhFyFIW6ZhChKAtIcWqUW1Cri1jw7aaiFBBiWfr2ct2QfF\\\\\\\\\\\\\\\/CroYCXGN7ZZB\\\\\\\\\\\\\\\/KfTN9B+bq7FSxDAFm+V\\\\\\\\\\\\\\\/MeMxPyvxT00LFydxSMvoHeKcQDVRArY3T3lVV0Sg2xievmGgaeqvi5gtGFRG4bFYKp4G5kOBohOl8EKTfdlZZ5Z7JVLtmogQOLDK1sRTh0r0SqclYNNOwhHtBcVdap\\\\\\\\\\\\\\\/hyeVia2HYIwvHOh\\\\\\\\\\\\\\\/eiFyU1leUjAJhauadV\\\\\\\\\\\\\\\/YLDsRHqahLNPH2C7DQWTGK9d1YIa+0i0EI7rMXX+S6yYCOBkx8aOJqnNxwJZFUR54YpXypOP\\\\\\\\\\\\\\\/E\\\\\\\\\\\\\\\/kMVRqdXLO0V7nOaQvcoeGyPXfJ0+wwgCMRqq7N5dO5g1QAke1xo5SdhUBs8Wo7DSq0uxWoMh2a5vCXtciqNpxZQZm3dfgG33jSrdM3BSatLn2XBuKaUJMyg\\\\\\\\\\\\\\\/gdEwIfx02Vl5QpEMYmD59XKDuFxR\\\\\\\\\\\\\\\/409FlnkaW7jN+PS2jclh3jdY+uYs\\\\\\\\\\\\\\\/foEG4+R8vFhr0hnGfXoSTTKizcHeTKKmAG86lacJ2NiIUyDBWZTOou1drJWtnSI1JgLYSErZ9J1BtH5gZmhL7OC+1IAIA9leAJ5VD+qv4XxIW4d+EFTiWbxt3gz1nu6D80J1xJynI2ME1nd6NIEL6IBpuFIxQYGfc0C89xiEmMYNDxWoII2BvDOGQu\\\\\\\\\\\\\\\/6RDTKwjjjJE0zn5Rz6n9qh7wqfk7Nn8TLoisC77TgupPDTGsXTTIxRfZv+yyN2TyaERj5cde7dplCAdEUt430sJ5ulvYPEsUXCwlGoaOWo0g\\\\\\\\\\\\\\\/6v2iW+db7Nww7pNqNTuROpbeJkHG2Qr6e63mUDH2ppGB4Y044K4K0PKxf+K31UgAdj5iSV3\\\\\\\\\\\\\\\/0OqvswHGZ2K5n1ZkmesiFPP1KvsiidFc6sHDdckp43BPY0Va1b1idG18osMMfmj7avuEfbx34BAIeNXt+0TM39qctp9OUicC+ejuj3Y+ZOr80JutB4z+4O+xxLxHrvc64aNCxo3O9ijAjOSSzqApAHF7TikzsakirwK0tBeeI2iZvYeRKOLMtH35ePktEy7nQ2IOyCAi\\\\\\\\\\\\\\\/pMTZkFjku4UzlFABO0RHJ\\\\\\\\\\\\\\\/SpZUUEHy1lt1UsUP82XiYMe2HZLmhr23g8twpnxRYcpfhWJ+VNz2vePWlRzk5Pk5fhuvxmqhCeOF8xBY4hjAh\\\\\\\\\\\\\\\/YgnHxj1VokQPwAPcqU4SqD9sLQMcBgd6j5BbTnBnrMwr6aZiVBmKXvuSKVgnxIDMYTmYBC5oGbNXXEyx6JRi6T+URgKDpStmdQZN957rRA7GtFKZJrHrCzOZz8M9T3AGAXM120qcuCAAnKJqaC\\\\\\\\\\\\\\\/IRUfmacr3laQ7X6KrMohstD5JgOWEvkwl5iNS37CpShJ4N1Sqnq0JyHw2bm2eoIGPQf5RTK+\\\\\\\\\\\\\\\/Bb2oSrNoxv6pZzOINk80cBL\\\\\\\\\\\\\\\/EHKSvz\\\\\\\\\\\\\\\/JCwcDX8cJPjPbQZy6Za0nTRib8iFZY56+4auBTccZEjMOj7bGjO272PK+SPuCLX8sz\\\\\\\\\\\\\\\/Ulok+j4GJhqTgSeNKEzRvO31CsWfvKhwXNz4wZ9eVQAj0ws6Qiq9XJ1eevi5Dw6N2Hhu2NOEilRhv6IsMXuhz3guFt+pD4+csmbSvdlTKZs1FC0LKVw3p3DVslaRXch8iU1I7uNlMLEGHH1\\\\\\\\\\\\\\\/ZTeHy1ALJ1MwM1UlfFiCeg9i2lqyolfOM4stWVAYgkiW30Eh8lQrk44kSxR0G8dJThwhl5Q6zgVgVYFa0WnjaYvcjAU6mwE6IkoRoPoEcic1iJjrsPvc1IOCmkunUaJarrWscE60FbokjvqD\\\\\\\\\\\\\\\/GPGGodjQf\\\\\\\\\\\\\\\/5uGRcS80ct+2kj9VPc6N9lY757+05SVTqjW4UYVcW+HF\\\\\\\\\\\\\\\/Mng9GLDvS8J\\\\\\\\\\\\\\\/KQO67PF618HLF1HPAD8ScDg9orT5zks8Us4APSMbmoJ5EJysA057sEr2EPe5ywuOewflvbO9u7QHv5vkA0YTtVBJJkvFqZQtMnFGB5Rl7ZdF5t8YNxMup2YJAyP930uUz7PP1OVOSgaXdL5CRqj\\\\\\\\\\\\\\\/i9t2ZooQPfI+BFthYJqxpIsQBTEUTKijeJknclKw1vUJSSidYRNphZNcM8DVsd5O3hUTqPcN3KCMPtJaAisdXNlJcbU2OR8pbi1re9ORV5Fe9+pf0L2XOmKGFhAN7UmMS9I7vFCbpLIC46JA8\\\\\\\\\\\\\\\/BFad3fdmeW2JKifUyLj+Q=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229m56nCc9Fsclhk9X1YChYw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fd83a1c572b70f859f953bed2112b6b03715e36c72dabc414948ddc4c45407e0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002646.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002646.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002646\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002646\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002646\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}