{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ovRpfIRL2Wyd3u637cbeKpn2a78TPYm6ifLM9DQ5l6a\\\\\\\\\\\\\\\/z7kMLr\\\\\\\\\\\\\\\/Lp8gHjHPcBdOn9qU0mxpx0tbzvOYH87ioHNwKBEmLpLnaw+W6KMDNrK83I8FEk2nN6KufemsTdWE0pUMRD7Ie+JLui3BZubT2ynCf0mKMJUYfKK+RhrbqPozN1Q88klO84gB3A4\\\\\\\\\\\\\\\/TKPiGlubtyA56sZocdHXlYZF0Ymhc3AYtAxO\\\\\\\\\\\\\\\/LxuG58ysTT5Zl6oUB3g+2WXdKPiyh5AYZjho3QaYVKpTQm6wWh1FXgcK60ZZXLJfChyQD41\\\\\\\\\\\\\\\/DCy7ufD5YXNXj20Wy5zn3xm5eAPVDVhnDHfkYlqxqlChNj4\\\\\\\\\\\\\\\/x3uXjpGV\\\\\\\\\\\\\\\/s0CKcOb+GWpmOzEfwvXNwwnVl8nI3E2FgRZy1WeQQkomxgA9zYeLom8I6dU8n0\\\\\\\\\\\\\\\/5yEZztqhdiDvEqaP6xZSHccahJoqgv3mdfXodO3Mu69Fo7riKqysUyPN+Lb8pb8I+pjvYMLw07lUuG4ZXi+blsswi32Ai9fmSpCpRs6SYSnicivr8igCIHsgMmpBG5LT11+8yJJNt8jX3ExVsNOkNVcogYThh7AdNAW5gLndcpuZJ2l9jH+4iccACwN6\\\\\\\\\\\\\\\/sgykNDpGBuzEN5093NIGsHt2PpvfdEDAa3XTZM9sRZArVxoIER\\\\\\\\\\\\\\\/ZzF+FuRuEdaw4SJSt\\\\\\\\\\\\\\\/kbRNKscqJnK48itmu7mmBKFZcqxEhZ3Sy0TYEvAiRDUaK9bbhFWJfeqybiKPTIeWuGRRULFsPMQ8DJXEZ40UI2VCC6uot+Z7rGvJvoelBD0nEumJ2daZ\\\\\\\\\\\\\\\/irPQ6HC81OxlXey48TWt66Phu1rsXR8qJdTb5gYn0zDdC\\\\\\\\\\\\\\\/oCLeOPgRMfRsDUH7eKZm5g+qucqLJilzfWNWAhT6cK2q8rtDifZTcVqTdlRJ3NKWCmSFXbEx6kUiyF6DREoVPsXTzOb3fraKrcSFMGzdT30mlFnmksJq+Cl11Z+E\\\\\\\\\\\\\\\/2NRJZtJ7SANZU9V\\\\\\\\\\\\\\\/n1HWXKrkzryMZfXz6jeWofRWQTwIfoD1Xcj47wCl44+eG3\\\\\\\\\\\\\\\/iWVehRrZjhBj8po86csuRlbJzXqGVr1Ojh6zBFKwZ9lBXncygKH7DMH+VHTb6tPovSi\\\\\\\\\\\\\\\/wnGeZ3NZPI5s14IdEk9hQDDU6sYBAeP8PlgAlmFTpvUyEaovXwUpWI0LyXeSF0xVBPrK0SAT1K\\\\\\\\\\\\\\\/DBtGDlF6Pz8d4qWbvjLGOqIe\\\\\\\\\\\\\\\/e8IDfQBFkPHSUzACHDuVUhn\\\\\\\\\\\\\\\/e94thZbD+kKxkTbym6dcNCyZe7V3\\\\\\\\\\\\\\\/Nodj0+DSuVkGvkFttbafiD0lGigFe0OPAhfUEVMZuhnfzvDEVrZJrHziY9MFDU001MKtZ9GxuZA6fEzUoFJEBWKuZSm\\\\\\\\\\\\\\\/ioRriHc\\\\\\\\\\\\\\\/T3eOICIkjLrDm+rG4cNrTObG0EFKcSK5nJgu0FQTe3NpsiB3Ta8ti7lkJHwxvD2JkNoJMWFTlzwMu3NcVvP4NAieNE+s5awVn\\\\\\\\\\\\\\\/wNEPnAIGotfiS8yfhQ1OlBDdX\\\\\\\\\\\\\\\/o+\\\\\\\\\\\\\\\/Ite\\\\\\\\\\\\\\\/iipRNJZVptczJ+fF3r4WfTPRuEx\\\\\\\\\\\\\\\/aEiREdcyUh\\\\\\\\\\\\\\\/QMAgz497AzoRgqCakqhFh0+EGd027W0oyHrH2P8hOpNVitWsj0xmUq1fZAtd+\\\\\\\\\\\\\\\/JLud1YE5uYHsdjwjNkUQ6K3xkeXQ56njS4m8AVC7U0gvG9+CwIP3GvLj\\\\\\\\\\\\\\\/AZlIIReICAQ30lrPkgVL+TNO+LVsa9hCH4xilqdns1zKbehb1K8yfQlyzMkQlq4eyyhgPJJyOqYYXf5lygLLdJDULzm\\\\\\\\\\\\\\\/FQhgmqZjGcsHPlZ\\\\\\\\\\\\\\\/I758HJHbhavY9Tr0zNuVTBVqebl12zdkHVv52B9jnJzQ2gIcbUsdKN2Ib042thv62GpskFFltkSxp2gktH4eDPXrtMfE2+kCTUzJaprUzCs0bnlBiU4M4JoqIcyC2dsaj5L8cMBKUSyioUP8kOMkBk\\\\\\\\\\\\\\\/hft5m5Pm2NE\\\\\\\\\\\\\\\/mYR05K9wu5IOcFvPF8+Y\\\\\\\\\\\\\\\/zg5w9eat3w22E1TXKiXayu26LBu2qp7JdFitXjc8\\\\\\\\\\\\\\\/wt9oIdgaiVs3FbJd5m7P3h6\\\\\\\\\\\\\\\/Y8baxPmKOHIyGTbV3jyxSdoMKJTlfFG0lyS5U1BpZXTMPIXtW88fathjgX5FD33OxkfaQAHdTLlDQlYktXEe+TncOHWSJ0td0hnnE\\\\\\\\\\\\\\\/q\\\\\\\\\\\\\\\/Rvrbf0XqYJHAVRXoKZ0Qp0KKsjMx\\\\\\\\\\\\\\\/4CAJEPRgVwhx\\\\\\\\\\\\\\\/VPGGPHhX3NMM2mfxhdqZSnHFnw7Pefe4cR8c1zhC7qqHI8K6HA5kgg0r2IMnmx1CdTIYJXTCQ6Q49xr40ImSUAW9lQ4qypdEcA9E\\\\\\\\\\\\\\\/vLNOInbe4GKsjL9qrW+aYShTeDcwj\\\\\\\\\\\\\\\/KzQtsoNOkprBhvqNsguxA8GyQjliDXccQmGsOpQrkLbXKwBfbi41YdrFSExg8l5yBLCF8c6kNo3gHCqj4oativcMkPzgtEedUyK5G1713mRdD2PJpfSCydspf9cwmH2Iq9wdjSJkviyinHFdo3dPUbAgGi0W3HV7GowZ0TliBzHyftTR2mugcviw1GFnsxzk4T0pirVF4C1Ykj+FIWtxogtwwYz3LP1YKqPtbz4GpjyyoQp0nVnelgo1DDdwiUJWRaxhB\\\\\\\\\\\\\\\/PPhat7l4A2Lz3E9iFyfS0lkXa66s6Ou+E+sWPwU+NQqwNAUEGIwVfaeKPJ7XB0ln+e0R+EZ8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022y4y7xtwGrYV5QXDt5Bq++A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002293d9398435696eae3218a86973299d0b713d5c5fc3ea18c8ba1ab19c510aa73f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002646.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002646.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002646\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002646\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002646\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}