{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ORK6PDjn2+ZmSvf+OKh+NqnhYs3CMDejjIoB3u6s7zHPf4WJqLEac6Ib6Y0Q\\\\\\\\\\\\\\\/1H\\\\\\\\\\\\\\\/xohX2Dq4v1jmxV4ZciHgrTMy09YoY9WeYG5ytcDy4aouoDOpjbZIRl+y3iRvhFGS\\\\\\\\\\\\\\\/LpX1V\\\\\\\\\\\\\\\/K4cijGyueLouXh+WcG1LFfSm+Xc2quysipzglA0YjEJasaxOcaEw9WoesXaq6Dr+g7JBqiC2r1C\\\\\\\\\\\\\\\/JN2Dk9FVctjvmiSg4LOolUdB8mOOccVjq9uuxy7aRugoJKoThBad8ibYg66nhUA5qTioIWoAhabMCZeJRzOwYJoTuLxVX+msnfEq95nucEutecAz8Tw6ab17V0mx\\\\\\\\\\\\\\\/fVfc7ljhkyqmVl01HXXjLZi1kZJSawwBBGVYxFvsrZdvWg+N1OHDIYkSjqmGBU8tkRfqY\\\\\\\\\\\\\\\/VYpeaQYPVRb007LWPSoIM\\\\\\\\\\\\\\\/oYp11+4sEu0IaM85wqkK4i4fpRybTpJ+7+SIUZ5\\\\\\\\\\\\\\\/W+hXUwvweUrC99LRvmDUpWwonhbzdUIVQvcdHXgrCbLUaor8R7q1tC4EPCISi7QCAYkhoZHv1CjtKk1vZVubIvsonz1r10DLMHtngo1\\\\\\\\\\\\\\\/noF\\\\\\\\\\\\\\\/GcdlWvv+fWdnVNZAJkRR49bNtk9Oko2k9bvGs3qPVogcu1dedVJBBknHwsJO3NrcIQRyutt+MNMySYdW2nEPirXQGq3P5vuiPX3wzrXm19MHjck++zI4AD0eoDh63PrXXZT0KBOx\\\\\\\\\\\\\\\/oPr4\\\\\\\\\\\\\\\/MdIQ6Aq9SZJC\\\\\\\\\\\\\\\/nXoCuCaR+QsNx7eQOFGoRJxNqQJ81OBixbk9EWri2QydK3vBUIqzNNJy2zMdl3r9dE2yOPxURB3QOKR9jc0q\\\\\\\\\\\\\\\/DdZnMPNA6o4CPlrgRIhItF495kAh9dnPNtzSYuhzvx4zgwBZkK5ELET+3NS8zKFYqoZqulSAuR4HUaUpwdUVysOaXqkoGWCEjXpmZvrFgQac\\\\\\\\\\\\\\\/6o\\\\\\\\\\\\\\\/4MG\\\\\\\\\\\\\\\/GUlwnIIB5fnjXuv7Oom70q49wcv0iZPAzoBM2fmVIotU+GzDmkgnTo\\\\\\\\\\\\\\\/6cJ2V930TdJE1N8zTvOHMDoVCEnDbCn0SezUxPQ3zkdHVgu8506oEFIu1cwsaAWiYwdgBqKwQgvPZqOOBlZiq4JVt6liH1hTtdMH1eFBCAIU3Cyu2xq\\\\\\\\\\\\\\\/V4TdLsJ2onh7AlV6ZVmSZvpO9yq884bctdhrnS1n4bJA7twcZKRshSdUs8tJX5y1jXP5IiGzGEEX+4\\\\\\\\\\\\\\\/ZiNGJfq4ZVtIrMKYgFBFczUdWAK0yocTUXc\\\\\\\\\\\\\\\/wLWxZhz+0aBylKfPa0BA5DCS1TXYHdKKielXsRtAZz\\\\\\\\\\\\\\\/9rdnbEL8nbtSN8QKOhczrqXqHqpAF5q\\\\\\\\\\\\\\\/lNJB6aYQ8SBBRMGuEMa+hBiVvHWgGDXnrAIxiMXyVLJAXg7ZuoCq\\\\\\\\\\\\\\\/BKa4mdHJHbMGizENntuPc0vBj+tFXypm1tDkRu5reWA+rcclyMIbarOQuZxqa3LPu6HgghUXsUS1UaHTgCBffR05\\\\\\\\\\\\\\\/d0mwbIOc8h+nVqJ3duxsI9oxqLce\\\\\\\\\\\\\\\/HrFUQ7Fn+vWRFVbS4Thos\\\\\\\\\\\\\\\/uniAcyAwdNuHoJpCkp6z\\\\\\\\\\\\\\\/dJAfizTruFfcwa4ukEd32w\\\\\\\\\\\\\\\/buCGhXm9VLcP2dhMzHqUqfZ6CZ0U+CnY9gk+ZIbx2I9NsJQTltm+LTxAsuID1T5vS\\\\\\\\\\\\\\\/sFuVihU4JCKzCYLkVgtUTJU5NIMVw5sg9NdJXGaMJlzglLUN9smAWXtXr1AXLBT7rH2A\\\\\\\\\\\\\\\/DOKQCEW6NkgT79mq1zIz1kIP3ET\\\\\\\\\\\\\\\/8crhwMYB1ewx37LHp1Olkh1F2ohdAdth45qqwUa7Kc91D4sDWu48DWyRL5+vVE8AfvhljFZvEyUmDvYnbO9pWiMuSR5p3IqupoL79gYmgD\\\\\\\\\\\\\\\/f6AeF+jB+inpXq6yRDd+BrLb2niAIdXPKZCurFodme21lGx\\\\\\\\\\\\\\\/Gp6L1QhAJE654eSBIcZ7i2sUKTDYB0RVlQvWnw31nWRH3ayu0FmBdiVo0PhP74QSpapY4gZOEl5JzYg\\\\\\\\\\\\\\\/h6iybdlCBvQIhchMJxRwoAQDfbxrDureh3Fqkvtzo1RTCf\\\\\\\\\\\\\\\/xOvhl0\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Xd9XBiAl9vDQITMzLxWRMDfrVEK5aJYAhswtjgKhN0v731MC4VQ72XUUdt3EQ2\\\\\\\\\\\\\\\/uVjDzOk2eM2lQVhwYM7rqo8OgEneb+aZGAEqsbOs4dKTKRfKh3nzhrk9tHF39Oh7YMF8NuPc5GbNGArayltKgcqmyPsAG5u\\\\\\\\\\\\\\\/y+tvy3xjcuPlUT5+m94LfEZEZjIy0\\\\\\\\\\\\\\\/FNZBKn7Bb30+67+FwioCDscF3mPXU5J4Bhl1DmyIwuCDyC6d6rPx+1ebvreS\\\\\\\\\\\\\\\/x+k+yunWcmDVxaRPDWf9bhYvYvPvIvk85bPLVdnd0xc0UN\\\\\\\\\\\\\\\/4+QsX8gVuto+4ec7O7u3rmDCplU8+nslkpWI3zNv+FDoPiT4HME+4ededQTj0WYcv5f1CNx25pLIDXV3ZVbem9YXdOYW5gP39L5G32U4simrpWnl+VnChKogBqBxt6idBaqeDhlApFth2SNA4YNBAM9uyRZdkUsQPlOmT5S+qtfggtby\\\\\\\\\\\\\\\/zLkORAlvSh3C1syjXUmLhmSLkXVivmmfXytjNIAaNcJsLdjtkRyuoqhnHV2GOshqmlc3dAMK9khjLghS8poKnREr1e7i275h9wr5K9Ds5wx6vrN7sS60AzSkLBBGArgV3QLCAoQHZeSI4wopGo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00228Xc7uH9SvbmrhF\\\\\\\\\\\\\\\/bf3ohhw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002210b0c9d849d79ebb8d62bcd9a6adf1bd287b914cbfc6b036f2125fe48b844d0e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002926.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002926.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002926\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002926\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002926\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}