{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022nYSq0i1sxLzuxuiCAkz1Z2FACj88AcTyrM0FIv7rL3UfOoOuNAyXF1xkKuwAilibOmuN6+h5hrwzul1CF8\\\\\\\\\\\\\\\/K79l\\\\\\\\\\\\\\\/1YBZ+qDo4I+6KW6vt77rU2XmiOYeRdMMUxzk4hSly3KyXGwzoPNClfc5XzAvjI8dPuj4uZuQeAD3esFCicsSicefUlEm8HhaqYFlls8EPZCDJvHJryYKOU0LtkUNOjMawQTqQyrU58x6YM7tcSMFkLNoQZS2RK5VtspqYo9YamOAgqO4LbPTHghUsnha6vMH0c4iwPv\\\\\\\\\\\\\\\/FWVIaC+Ty+OAa+OCMUrP9w5YUAA12rzSb6pESuWt0pxZTF65vWlLVWWgkxhIElWvpSA9X86txegL4BilkPZVHXU4TXf2nmmjt5JtrXH2NbzTZKoKOiDznVyUv40f4rf46Qsjzx9ht8KuE0O1N4XH0EYJBIkSQrz0+pzVpInjxNb8D2KTF1oc95bdDgzaWOdfqJuuMKCjUMx4Gc1gZiDgzyRXwy6gqABcTmo2ngMYD6XZEIjXL62NBy+MBkwXuvzTGeH+rL5NICjn0V0esIEjhHcrBBZ3MGGxB19DdgS9me7Tu81SDywL7M4c7ZG\\\\\\\\\\\\\\\/VAnqBh\\\\\\\\\\\\\\\/zFVVVuzUqowKJEP1+15Mttxvgz3KISW1vh\\\\\\\\\\\\\\\/SU\\\\\\\\\\\\\\\/nmext\\\\\\\\\\\\\\\/OGyBalclyeAg2HzeVyZs6ICjypX1OZ+p7vAYDo\\\\\\\\\\\\\\\/NNmb5thCTTeAEXRJi+4nOOMCmq1HL7w79wFsk6RMHh+jcSvs38UsccwGAofROUofGtpz8cT63bHJFHPgqKArBrtihwR+XCpibSOQLZMpj3dD0suquaD064HoTvfVq0X\\\\\\\\\\\\\\\/iq4y9y1ZeVpRrviKt0OP7bnSx1qYuZB9SQ8GDbTCZ1Fsq1ZpWPmF8ocV+zu99UMxz6krEjV2hyLlfuIwMtkWOjIN0nQSsyQy4+VgkgXJMR8IBNe27yWEQHnk5PUIV4qs+ADxia0Fb0jPLlLyNXYYYq63o8mHEXAyFpXTJs5Tyzl6WSZdmhcYkJuj1S8MPu\\\\\\\\\\\\\\\/RmCA5b3N5H+ihYVowHfkMcbrEPzpTha21h8KGLCOlBs\\\\\\\\\\\\\\\/d+k29ZWdpNdUKyRrQufC6y0IKVLGaXk9eIk4pkFVwdYx+nl4g9YJxrZ1XPY7A664bnmVi0m3RuFVApPYq\\\\\\\\\\\\\\\/NmGInjTwnZJwmQwPDfeMfoqvxP4bkOm0dR\\\\\\\\\\\\\\\/1KeAdmBuS0VAJ+BP9bq8mEt4ekv0Q3OtgTn7bYVQDKtOT7V\\\\\\\\\\\\\\\/ATluJ0jGFsioZaBLFnN06XMQfwBu79UzhDgX3gLpSGxbatD5bOvFX2asNp+H8rAhmXI79dxEaL\\\\\\\\\\\\\\\/79hsnOfWCnai75m2aGOB2+7KEVeskMv0c9hTDHcxcWIUHjP\\\\\\\\\\\\\\\/iDVqjdxVoHxPLEYGzpy2vdug6wzgO8R43hdMnKJEPZdsR6Brr2Q8CWJridChco+qeBL8NlfVjJo4SPmYYqFIc7M8MLlSuUqKAb5cjvu1P8OOT5BV1LYWIU5qG43aMemyx4HISd3+Sy66LxY6gvxVu5BvVSfZKDebpmf2Lu77gX9Rs8GihsaOBO7MsyRDwH+GWqKbnC1I9VE5lNd0ReQXVqmik1YOSNA+NiqrXyu0e87XK5mim8jCBT8NT0JuzKrkAuQl+n\\\\\\\\\\\\\\\/CR8nfQ+\\\\\\\\\\\\\\\/3ypM8zVR6lVODN\\\\\\\\\\\\\\\/aiMT7EQKk9YDrLrEXAND7vDqybjN5MPC87idSfaOLx1MvA3w8clvapB9W8btU6VCnDp5Rnc\\\\\\\\\\\\\\\/TprZe7HF+vuiRoUrJFztEvPzQHGfhe2yMMqoNxjR3CQK3++P6ySHTu5oAmtMOLH4xvOz4PVkftYCYzIvqGk8nWNHH5RGpjbVqFSwAi+uD7hlH7sBQQgRa8LZbQtosDqd8gSgpqFyHMz7eWLNj7bz959+fHEyaLAOoR5OU92Kk4Mr9dWCJpYSnkPGqlAcFq8D4qmeEuagCJwmNGVE6QMnggjKMZk3+S5XK\\\\\\\\\\\\\\\/FrTU5A7QvHtfAERLJcEXwaXWWsO6n6wYdZqv1xyYwvtlfMQprd+JekU3yoAphgSS6J0BQbUf3kcuGs1tjv\\\\\\\\\\\\\\\/T8ycez0VDEzG2bC67C2smVfXvrN1eg\\\\\\\\\\\\\\\/6QGOZBWyUTmSR0xmZdQtWgreHfSE7kJX7Y6+QITUYk5EDCONcwPVsSmnS9IIpFyOiFdsrFeUxvWPxvJE4i40gRRtDSOKyacTva+ZrdkEJd+zy0awC1hKjnRqluBKoDmc45fl0+IvRj2OuiYws7oTa2x24Gc+1H8iGlmYH2\\\\\\\\\\\\\\\/9px3d+zprMNihZFyIk2cJb9Qwg+8+egj3peMSfNMFt6TC\\\\\\\\\\\\\\\/5ojSafJmO0ROYMsnNKmNINtk4WE93YcSWI1tlE15MpH3YU0nj9UevftqmAMF5dX3A23LgfshMi2M9i1yxDTMPgXJPQqZq8kDXGWlifC\\\\\\\\\\\\\\\/3Ylru+uGvAtSc2WYNtB\\\\\\\\\\\\\\\/lXIpIqC8pkfoAkcY4BFl8JDm2L32IG62btlZ5owwVMHhnIrwsVSwuph7y+sC+BjV7Kl8bb4PsaBPMXH84UGsYBpPaBiWDfqzFxJM7\\\\\\\\\\\\\\\/ht1sgNK4nAd4NEDs4pEIP7xxBHnbMu0MZIGkKCWnypmPOQ5YWHCwJF+fV4y9VrKGioHoi14IgDc68DBt7NKiWXAX1sjZ2xk4NDuwPDnLX7YjlrdEgDiV7Kerg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022vaq4VtBTwDE0yDfpS3drkQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222a439eac37947f81b6a3eb6909a03d3fbc4159a02f05165fc3ce02519d6f86e3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e003079.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e003079.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003079\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003079\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003079\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}