{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022f3V62S1REJkpXG2DL637hVtD3kKss9TtaLxrZT3PY+MOvNUA2eMOYgP337Z4lUfWF+\\\\\\\\\\\\\\\/gzSuCiJM1hbPyde00DMzegKPe9npJL\\\\\\\\\\\\\\\/8J5A+Ojap74Ntwr0bZ4yhHHC1QQNUx7pbD4oSrwHrKZ\\\\\\\\\\\\\\\/eLYQF7Fx9uYrkvhkRQNAd1p0argwXITSuKJUdokqL2HWi2L+Fn0tIxsF57u\\\\\\\\\\\\\\\/xBo60Ab9G+rDy50p5Xg82JTVlmT6NsY35iMlOSaOiw79nrPa5c71UUgE1efqfMsigAlsigJCE+VVwVlvyU\\\\\\\\\\\\\\\/t+OxWivAlku\\\\\\\\\\\\\\\/mnU+xje81Y4hQtuTWrJMwspXSpB4b3xsSOK3a4yjePeBjG\\\\\\\\\\\\\\\/irgmaggNpn9YkLhUyjqstvxtB4nkQLO4L2VYWzBFO0giWsq+v6QuQU6W+IxU9DAqRm0DItLH+zEdxdIykq50NNUXicyBuZfCTf4gox8rHBWCYY3O6yOBDL3H6qk4iuU83Rk2H5Wmuu51kyPCdGoIcELdE\\\\\\\\\\\\\\\/00HRX7Efq0HxBOS8Zh\\\\\\\\\\\\\\\/ux8viYpCYDe7oSr+74Ac3yRNFeZC6Oc3rwK+v8ROGaKpDn2YKUR+BhpBsH2x7PjNVZoxun67HwU45IQj81fKl0kQiB7hSZtaDvwgXrDEFNFmUQ8FcXqIQHDxEgYzucvE8a3XyY+0+MaUj9Oqpyb+DVmSb\\\\\\\\\\\\\\\/BiPytjfmQcHtKSCh7g2uEhi8GXaUUAtLg2ElWMwePIuOXIO+lobUugNMObtk5adTmdbbjg67pYcRMpbtggENIr3IuVVMOVgg3SZGt\\\\\\\\\\\\\\\/Uj+Mf\\\\\\\\\\\\\\\/bRGMcQGyOfyT7i4mUfYlwtA59Oq+4WNtqWUl1C+r8IoTU9DpHhDE4b8V+v5iG7GNpoL0G1jJKTbecrkLsmyBf6Wr2+FrwsId7MTro6TtlqbuZ4CzvRQYjvOFCtjxmFSdw7YaceEPALYWM1jTmtIQSP6PrhPn1RQAMWRKW6keB\\\\\\\\\\\\\\\/BoBYIY0wLasQwIW8mo0AOKD8\\\\\\\\\\\\\\\/2b+NL87YouZPbKBamQ\\\\\\\\\\\\\\\/BBXgCTI+qFmSZDbPUZ9ZeGrvEq60dO62\\\\\\\\\\\\\\\/GkgJMeRRRTGgN0jyG+RlrQ+p90xwpDW8\\\\\\\\\\\\\\\/sgHsm4E2ONgPxltO6zOicn4mGVxuteVqum3K32QVY21CukHZnQFlgoyyVeshMyap\\\\\\\\\\\\\\\/mkCQh7sbG6axciJFbkqp1SGsrZX2lyFifFFAmfXp1nxHg3vCKds9ww9Hrm4NaeHg2KM0m0KiBu4ZsClRv2fnY2Cst9wF8X1NFpNOBwcjQMCGSiQBBKz131gensCR\\\\\\\\\\\\\\\/K8UFX5svvQJmAi76nRxV99AZU2K2mn7sH+c3SO9NrKa0OSHLIX93pDnNbR53ttx4FTfRJeUBODM6XhiBHvON8K0MGVxM5sWSrdK0R2MK+hP+kPs9Tbyul7wZNxOJ5UHQoik0Ca0SP7qK\\\\\\\\\\\\\\\/T62HnzOE9gPbT3aNuaGrhwJGlMbY6AJfkax+ktLPHU7n8+Ydr\\\\\\\\\\\\\\\/yRBPxFFUy\\\\\\\\\\\\\\\/DAbAMgQtpsSfWAqNOTD79nVoMW3iylCCIjL\\\\\\\\\\\\\\\/+HSYVyk\\\\\\\\\\\\\\\/CbLGmeqLMFL+ZvHOYNS5ocEXjBQFxnwobngAyIFn2qKKf\\\\\\\\\\\\\\\/Ot\\\\\\\\\\\\\\\/gGWShctataYiMOtxPLkem6qwzPrO35dgte2OVzRpfZULqNmhQpisjH+4DE8tDO6+6GvtdMHhfGzfX0vu5djzzzBqP1pWhEBKOFWd+7MMUt5fAs8l2XQvvskvT1zbrp8NUMOqp\\\\\\\\\\\\\\\/LnWucu4nnAOT5Ayyh1w6GqIkJ\\\\\\\\\\\\\\\/fW2sutNzNzJxZiP+fKB+w2bjmfoHVx2\\\\\\\\\\\\\\\/ZIRMMtcd+kCITFEL84I2JzNTrng29m3gxWu+Itu7qqMHQevYU8eVYYta2VWtEzX5pi5L9ZUsekyuK6rqCD8mLD2ELPSIOeZ4raVOt588URXl1A2I8eLpfCQA0QBkfQUy5+uuPRTA2TaijcsCVTEmAZx2iGmF7J+5kPwtPcTtM+fagVCo6CFS+pnuSxewCXih887LoLy5gQSP\\\\\\\\\\\\\\\/22qJZP6OpFS349gY3+uMOWwI9anmMKUknvHizUvF74pRf8jqDXk6Zg82dVn4gSK48khnGAVSYUhtdjYc2\\\\\\\\\\\\\\\/2kOv1AJTNtZG8ixvDrG0sNBGqiwApfX1NmPf6Zaz7KQTqejuBAKHs+lgADl5EQBa54wnoQsklod6Xm6c8kpw9\\\\\\\\\\\\\\\/mAUD4n3nlw5UxN3jVSKoUAQX9q2XexstnpVtLBqr3yM2EJuWz0fFrXN2SVVvs8vBeRWpVpu\\\\\\\\\\\\\\\/ZtPPYd+5h3IB4FpyeK6QYVJL392UV\\\\\\\\\\\\\\\/nN1wG73yk0R0wNXDPgCPL0iYzAVx0ekOne0RJFZjYoMiEzjK9CDx+boSA2g9UEbGMWd1HN3GKWj\\\\\\\\\\\\\\\/OWmX\\\\\\\\\\\\\\\/oAxPUgwevgWjIWKJnADPZ5gZ8l6Qfl0uOkjBhBcEXhojDlx2LL4cb3NBUZA56sEipvp14SYE0gWYkioOL7Hd3GezMuA5wVgICMSdJyJ2I4ssKSvLL1XJrJFffu3AoBBxKAiyv4L8v72dihDgWaKPNGAMS8ZFFIl9EKlzq6NIvxx+k7xJlCy9IMZMWqVex7TN+50ObDMKFoGVll2CkQUBm+fIcvpKm6e4hVbD7h+2KyXl5KkE6JdAyXg\\\\\\\\\\\\\\\/1ehhASLVzZtOPQqF6nOfUL2p2Fi\\\\\\\\\\\\\\\/BsAWX5MrRTglKcLpT58VNUfyx6HopnR3IwBY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022C8+z7zchmquezIS6vLss1A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221f381618e45cbc1f9992d1b57403bd8a61ee36eebb64d9d46af7d163d777b62b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002923.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002923.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002923\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002923\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002923\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}