{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022E28y8y+Xm5wDTy5lnwkQsL+Q3JwV7olImhKAAOmHWC+AF7QsglInr31Yz40YqryWuiZVH0Q+n4iyLiC3Jq1yJuXTo5o3AQrWRGjo3dDhD\\\\\\\\\\\\\\\/Yr5SLUJF4NdwYmiZE3BOX1DjubtOPBIqudbfSEdJVqlEkKlLj6fRJutNYFS8ha0+4ps3yNlFTTv3SXK\\\\\\\\\\\\\\\/ZxN2R2tLvUtSiBVRKTI9xiKfYGaqXrEqRXmLixSvrhkQBNnqMfuJ\\\\\\\\\\\\\\\/dE2hBLdqmzwNKE9M1C8JSz5cI9joKAwfw\\\\\\\\\\\\\\\/zOkhvXqHPxcdNGifTmFovfOeTPpEmxWlWicCOqJm0+jkF+FuL34Ar5DrHaI\\\\\\\\\\\\\\\/x3191\\\\\\\\\\\\\\\/gWe6+7HFHRPSrEn5YKpE\\\\\\\\\\\\\\\/ubCMddYEFD1dFS9ngQLfyypd9M9NkacABEReRBTyYvHEKs0s3D3a8yKYlPcwOdpTrxm\\\\\\\\\\\\\\\/fkJUUG4o\\\\\\\\\\\\\\\/ODDJK+LVQr2eQ7EgoHuDcZUgXl\\\\\\\\\\\\\\\/jIkjwFDNV4RbQIIL3vO62oeA5lhuYcO5KJKCro1wzid1bGwAe0gIFsfqq9XO4W7KCDN46fblkZaYfFww34tJ26fnll+G2M262out3e70KM+xD7CgBGIl9lif9k9x6TTj1VeKko4fQK1ho\\\\\\\\\\\\\\\/VoFiXBErO2Bdr+cs3VI\\\\\\\\\\\\\\\/ZYtviSrPcEW5S12sj6QHlfP1CTgiu5C5ufWPRxKJ9ZUN+ECXa9CcWT5X3QylLwZ+sXkdcZgWIg8VyBDnxRsFbtYXLUJKeCZtYYzOj\\\\\\\\\\\\\\\/bOLRsookTszu5kcHQGRSLwxGohKxNhtwHtEzd8diMUD1xxkHskMpAdJGzSzY4KMPtpRz8XonXrTBVTrc5VOxNgtCoYmxWRKk9BEHKGX5WG1TzNlxaSXRQHSmw2oH1NTczI\\\\\\\\\\\\\\\/RfmAD+Drq+RzlvLjM+Z+CPysD3R40uMs4YGv475wg67QU5F2OeiS+bJoVivRkp8XwshvGU5tIg2aFNyr0hgo9FcEDcM2KGROTLmooCwjKajSaYXVHvI2IQc0z9wNEI66mjUBsAJor4FJyW+lGKsIbTmiXNGe+xPE2Dj55WthBfed9\\\\\\\\\\\\\\\/iO43agS8\\\\\\\\\\\\\\\/YqnO9JGaED5rcOUBqykm2NzmlVre16W\\\\\\\\\\\\\\\/SRQ6d9\\\\\\\\\\\\\\\/kF0IozQyMsGx+P4coJ\\\\\\\\\\\\\\\/09lK8t+\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/41iRaCvbOXPRt4qjk6AU8MLRjHwSK6\\\\\\\\\\\\\\\/fz736e1e3iMh0h1H4OcCC6FsQc976krepEpu8ad9QgEhZoxoMN7HeHPyfvEx+ITE16Z8ryqlHgym4cb7fkBwLq+UvScK8wOxJfyvAOkv6H1Le1A9uPBoDRLUb7n+11Mk5QYQtx9+FaIULl2LhH4aSr00D6uosNpqy2dd4S1UfKxTaSLeLzBRyxoiM5QxNoVEPMgtsD282rofiUglAaQKFH9yoVAJ+Li9nAnFos4vc012o4r2T\\\\\\\\\\\\\\\/BtVXUBSEXhyYoPWRYXAcSH\\\\\\\\\\\\\\\/PAMsQZVVi4xG1F4hmNN\\\\\\\\\\\\\\\/F4TYoSwKSHvQJkMbjVIFimov9cQKpR5ncg0\\\\\\\\\\\\\\\/AKksJTkJ60WtNfbomKVxf439pJfTKsSfH1QuH8er5mYJqG15RXtqmSmcFwd0GKIVKfXotGX4Rcl4+CAUfxQ1f\\\\\\\\\\\\\\\/JtO68rSvd5miGU2baNiAmgNk3HxpVM7L3xVzHr3Jix8FZL\\\\\\\\\\\\\\\/bglYfVB84oRO1J5Hz6HnyRTAni0Y2QMHMrH6+p+I2t2MfZ3RvodWkNSr3m97kIagB\\\\\\\\\\\\\\\/QLYbH2d3Me+vw\\\\\\\\\\\\\\\/HASfRvkpGMjPEVrNKsjTSXVP98QAWmsfS99HJ8pqzrMJkdFHKGhIaNnhh\\\\\\\\\\\\\\\/h8PBMUb3RMnX6+iK5LKb6ytdFz1XlawtCxJt3hWdcX3Sblkn+v\\\\\\\\\\\\\\\/OWLWWux\\\\\\\\\\\\\\\/VUBcH4fTYHKnM6EYwf+vfc9x9Wh6OpZL4ZrbpSbVTu6+wuN0NXEE1imCRHZJB4PQkVfK7Phuznv+kwNQ1KrncjixB3AGY+mndmFMCqiBpI0tl9IEoGFT4Tip7YsCSIQ5ve0b140IlXAoYyqykkCkQdM95ozP8HvZ97EODuNsGRcYqoK4TohXm4fHH\\\\\\\\\\\\\\\/nm0r83gZGXqVQ+c2rpVXdB\\\\\\\\\\\\\\\/9M\\\\\\\\\\\\\\\/qNCJ83WVP8bXXVGgnFO7i4xLTH4E+CJ2pzNoso2m6cWMrjbeIlXrlLkGqXYy0tFjBzaIdd6q\\\\\\\\\\\\\\\/d5I7kAmPz1TBFVgyZjeAhkbWZ8GMgrmX7xsWqqBwftQ00TmxZDzLXB0AbQEhbDeUQbNvPURtesUH+vLuqnhu7R6FUhDfVnrcuBjAT4xCCZ2hCxz33qtIVrR\\\\\\\\\\\\\\\/+C0xboZCzCG4xsdWsze3Vle3eSlZBDHv30y3+TIcdiG7um6atuA9PnjOs4chx8GL8JtUVbCSJedJX6kN9oZklLOJQ+6D1CutlPKctC6iC2oTogXzbsEZUmy4nPKVqVi7YyFwnSRVGxoeIl1R5KtmtlL5mNmCEmpmNeUGhuSdFAMS1OK1XAy0Z\\\\\\\\\\\\\\\/HBvOQa5WfTb7SK6sJIRqEPM3EzejhZM9VXLZJjQSwws0odi+f8iPtDb2xxe6IuFjf8fZUNwh5OhSDZaJZWSY1DjQ3VVEBBhRluGwH2Zfvc7Yzq80nU2rf+ghyE7bT90V6TQonUndQHbgb8zibxelaIi5QTNXjKIhWv2\\\\\\\\\\\\\\\/M3f6Rej2TdBvaukstpvcfkPafvSbSQMoIn2fnY\\\\\\\\\\\\\\\/Ao+Rx+w4C0gqoydXIS\\\\\\\\\\\\\\\/kt8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u002289JmJAQk\\\\\\\\\\\\\\\/m0QLl1R958xUA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220ab5a033e0c83011b0bd8bebd5a04796afc8dda3bbc2b468ef301678449c9eff\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002753.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002753.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002753\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002753\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002753\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}