{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/7TVRWQYv6hmi2NSSsJByYCK10JTeq+ywHUiwUJvRESTMcYiO\\\\\\\\\\\\\\\/dvTv+eTQyG++cI9B0BoIAZRRqGInI0iF9lyxBaDP4Yxw0oqCzMMUPXHHgyos8lYRLBvQuFt2QUfFNVXT6+lOJf+nW\\\\\\\\\\\\\\\/rYgZPfXub4+egA\\\\\\\\\\\\\\\/35dKBpJ4TWvRlhko1Ze97tPEJU2u2w4gVfhZdGOuN6P8w4nqWU5fcmHlYwmEuB+dbmyVrewdB5OtDA5K9\\\\\\\\\\\\\\\/U0FtwFVn1+OsyP2w0JYLX9AfHYRX37hJBey2DfCzuDEvUDBZFNU0D11WNqOn0WJYyylWFtgkvZ8ck4YWKpr6CSJWS1tVx9ZsYo1uabyVmMSeCEVTBCV045bQeP8mhogVrvNeu21j\\\\\\\\\\\\\\\/Ljh9e2csPyQNzDkDmI4YMOKKDlwFFpt+dhZIRBOzcH8I0cfZtPZujwMT6x8exiwHPDYrdGGh9Aqra+yXnavV9MNFJVxOwOSKhnZ24VUJWjYD\\\\\\\\\\\\\\\/XNizVpv2vxLLBPGyE\\\\\\\\\\\\\\\/chO60I\\\\\\\\\\\\\\\/bjoLr+kLEoD3QMRJjymoBuIhG0AaZSCtSi\\\\\\\\\\\\\\\/RAk3u3+fm30yGSBYbCZ04rtM5Rqg2xFDglMO1IalWYaseOK19I40GoiLh5DVTxKVJ+Rl5ezEXHkHDTDOgYHcAccUrSodrqe3d6yfpAcybcdVEpFf0Pg09p4P4zWjrP2PfI4Z4kJMM1q0srBK40\\\\\\\\\\\\\\\/aZ7mgpWbYpqH9\\\\\\\\\\\\\\\/5wCV6T7RIenZn6oQ5J7\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/lYE+EGfD26JYXDkrsOybdN20ZwJiq7rB43opLj2lsbMEvnLLpyMzYh3syqnv0nLb0GOXslXQ+lmGZWTLjXOEXSjATpMc3vDFdXoAR3iZmCiRz+cqfvqSETAWmKuTqDRefs5NRbIAjj4qqpVJnUxFJLa1M5waJRCzSRaKX6UsfC\\\\\\\\\\\\\\\/Iyn\\\\\\\\\\\\\\\/MQ+mTzdfA1WMAUEMWmU1e2xoGbO3ov76GJuCKMoFSvCWw+2zWsQNtRg8pnuU2oz8SER7k1kVxaD8TtN31MRBrEWkyggFUcNypGbugaIMlo8Y8n0Nfg1vsmRYrsQiPqNaPV0C0UcTfow6WFPYHkL+t6E8J7FlFGIyahLce69iQ0yq1vkixGdfiU8959MKNp5TgL1Eftyy82+LL2K05Gj9oK\\\\\\\\\\\\\\\/LCOib7aHmvPD319ChotYDb3WF6lWC1sHwD4EUv4ACtTPWk5LToMl0VaGObfJec55k01xhPGIuBkE3AHhXNLXJ\\\\\\\\\\\\\\\/Av6XrGMTtlXH917ktIqZ4yu6FbVazTooBYwpZx9\\\\\\\\\\\\\\\/Z+PP2iO5om9Vp5VXHQKG8fnJ\\\\\\\\\\\\\\\/ZdOSylUWqEksOSVV\\\\\\\\\\\\\\\/E252G0dT4zvda47QOPVm+7EwHah4FDeU2ozL01B4Ai2E3EjSDMoyuxFSBwCpuc5aPPHC81pkN6\\\\\\\\\\\\\\\/bo1l+BO7D+\\\\\\\\\\\\\\\/P8RAu2h3CsXNldILtL3jJ+t9ZW2NJethQhBC0hnj9T1K8vDuo8ceym8tYohkXS3SynkeA0ZgV0TOs\\\\\\\\\\\\\\\/98bl+Dxd9N5nByMTFJk0VSCgiuE2JYcKSQsx\\\\\\\\\\\\\\\/jYJaCpPBnTEi0BjPCTxEmcHaCZX10Gv6+KFnG+EEbEGkg+AwxX9MYIgVjmfTy1qgyCGFnMMLlod+i4p+djp11XgP5qCq6z+KqDnB8laqHouXTUVugna3t0fWwkF9Hwa8BeeRJAl1DkT3T6PHGSacsoWmw3k1TtAF5+XAV98Dc8P6KZtmngmWsg6Ce5VwnVKGx4mai9MbkPZ44EPlJgFBBWL3Vkvyt9M04IEbdfgCz4e\\\\\\\\\\\\\\\/CmyFnyggkJaF0ExzTMg3+0jr1QdU4DVe29x+GZ7BYT2jllVbqQHhEPiEiCn\\\\\\\\\\\\\\\/HK3QQj2ILjiIVFCNQFgqp528Z7xY6sxDZhOImPe2BozR+D7+atpjrZHfX81mjHUHSO4LR5jGud9t1W1UnzrwVbAynefOoOgG07mH1F1w04GqTZN37phSGSPLZc3Rn1QxkiFMuz32Tctrj4xT+625Z3KMN22WlhEZMXtr8s37EIochciIzHXWaEiksz9KbZUcVBvmqn6XidaGoe7GYSdXZ0fsX\\\\\\\\\\\\\\\/JbcqpzPR8zCghWZZyMs+Kb+rIikPLlsusNB0SMl\\\\\\\\\\\\\\\/omMGloVefyqhPKFIOZZPoP+iMITZl3KXFOGvrfACMzBng5TMu6vzD56ODbkLTuAVTSOXL7filftEyX6T2Fd8NOmiLZECzUfecW9tEq8A+MfoIudwmZCKRrrxLXkm0KN\\\\\\\\\\\\\\\/VUnrE7UbGA6CRGgUNYIUGTHWN2sMZKKMLcpkbgL8AWnFBj0jZ0YEQkshe3DWMvz0jqbZ967zaZqEpBZjVXnLeuT7gPTnDjRBKn3DuGr5okz\\\\\\\\\\\\\\\/cHNSFTyfCeMU+pYW0ys4ehNJ5IwoEG4A9Fvp93zRb7dCnxjjSSlDEoItWGNJW834z5ZWa966rwIbYENQC5GhcInP9eRD6DCfrOPRgrJhrc8prKzDOYMeBdagWz\\\\\\\\\\\\\\\/lpT8MgFMTrO6+\\\\\\\\\\\\\\\/qdQCQOOVcnu3VEGlEoonzOf\\\\\\\\\\\\\\\/SxNDW6\\\\\\\\\\\\\\\/VSoGO+XVk2\\\\\\\\\\\\\\\/Yw2y6NSQKRrXs5\\\\\\\\\\\\\\\/jcqnbqrBTzataPqPo6D7rXPmWlaeyW7feSBQXbj11oe8hIIY6c0xDZZZlyY79vxNL+ix1jfWCYeb\\\\\\\\\\\\\\\/uzSvX5JElqB\\\\\\\\\\\\\\\/N80GX+9h1UBvUSmbuI4vSS4btDWvUkqcNU\\\\\\\\\\\\\\\/x72wcHTKiXg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022uUSG9RL0U70ObWV9xY\\\\\\\\\\\\\\\/Q0w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222b01a2cc1f21ceecab8fc35f5b2d43b1d7eeaf86b03049f74682228ca40bc43d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002882.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002882.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002882\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002882\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002882\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}