{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/Sdydpmuh9f9VsIj92Xq06ay+Vu\\\\\\\\\\\\\\\/0JlPbd6fePP\\\\\\\\\\\\\\\/0ae\\\\\\\\\\\\\\\/TzNTNApHAd5AWPoZcyz+G9wR1UTv0Vn\\\\\\\\\\\\\\\/EAmDqKc4BPxKQhFXpWo1jm57AM8rqk+Z3bUMfKtmrQIlqJWZJCC\\\\\\\\\\\\\\\/kZOAhBzBGqwY9gzyu7U+Nlg17aUxsf12yEYRVyawIOVWZmRSM+qZeBz9bXr8YmWhLN0eciYJBY1G+zHwhuf\\\\\\\\\\\\\\\/lqj9jO5mzSkMdGWIJkd40l3DXMoTblvKqRdbv4MVlunbYKqGyHJk16ouHbdiDfiMKoV38Lm21zTg\\\\\\\\\\\\\\\/JCorlvfVRdyBb+ry0Zg4+5SJryE7dhP8oGJtfx4VeNi+TbG8eME9hkw5Bd9lmOAZFmOTh\\\\\\\\\\\\\\\/rPAMYnRQaOE1lKEXgbocJXkBl5Bmcj2D2mQSRADvvuG2O3WRshtwyfOleHyaASGq4Ij1H7sbh2QMNfYsjK\\\\\\\\\\\\\\\/f3JAPHyeIQcrq+U5G0mPQ9xAai+jKkbM9CBirfz4eayv3BQ66rtPNGwHCIaDQfbqrYiF+HTwqQ+AzPmBWhipUJRb74XzX0nTatvoRl1Ue0nL7RbNb73Z2mCOqELoOZBAvvRB86q\\\\\\\\\\\\\\\/+cJAJJ5kATTkA6sT6sbilbMZEovYs\\\\\\\\\\\\\\\/d3nzxRmIiMx4M\\\\\\\\\\\\\\\/mX9r3pKHhRZKh4ZL6u9EIbW7p\\\\\\\\\\\\\\\/VftRH1btWMm0sUSb04d26AbtbML82etMV8CzJ5Q8iAlRff5kr5f\\\\\\\\\\\\\\\/19D68FUFwy+yIKEqCvH8ebXNzdEzFLFlaLrrMxJqnsiE8cPTb2kzHr6etGsQrc7DsEp5T0flVwPMqO\\\\\\\\\\\\\\\/gV7fwEzo+AX8nBtLRz79OdrYNoeBtNLsU2KhnwpK0tYuUt1lz1+gkatabcM\\\\\\\\\\\\\\\/p2DFTLnAt9wSPwQZWPr59NOjMVPWkw2gscQXZBIEltQ9dK6GwYrGt7dD1lGm9DKujRDKubxDCI0dgMAzSwZ9j5jTSXmzrL\\\\\\\\\\\\\\\/d5v0BhZFivxD7vuhcQ85VntU8CHldF+ieOnAl\\\\\\\\\\\\\\\/1ZDNfvf1M3+2wMm269jwEZHGxU3I9czhRut87y75AODL2XL2uIjzNbFEogVJuPYmuN1d9aRG7NF4yQUeqREFZpGoj1KGkDtREskS3lLg2Mw2Djdn93j1+4CGtVck2wu9B5k+UaEEZO61u+LRrwjizEiVFypNyK3iMNfRFP9Rl6y\\\\\\\\\\\\\\\/GXZv0U17\\\\\\\\\\\\\\\/lnGmqPzWnpwgHSjTVvEnvoAKDXk\\\\\\\\\\\\\\\/q69s8SiyVSwjeLJNTeurg38ZysquP8eAfjxD9xeh2aFvQFPbgKCdtoKTcpZewCmnTU+1yL7cHYjMWS1t\\\\\\\\\\\\\\\/SRadWqlz32vwnyVQ5cO5Yjezido5wV6CZt\\\\\\\\\\\\\\\/9CD4Z2Kf4yl1Tn1RN7Z5o0GdJ++KgS5BDE8o7r\\\\\\\\\\\\\\\/DnD2tsuxpezb4JC6DPS3jvpnyY8DGhGZ2Z1Gj3R\\\\\\\\\\\\\\\/2HoxVaxWV+TOcPj2ArhWIRs7fDz\\\\\\\\\\\\\\\/weMnPiorwEHRybTi45MG50VeoTgWiqIM9eDJbHYuQq6B5VhqLG5y3lz2Trgvn3MXRbaN2jLLIvc+wmtjFyFJX+AlVDARTcnUr\\\\\\\\\\\\\\\/N8cRu5NnXkCDebIxrQtJsqzlglzpvOhFN30GCYgbPnigtq0pUvWKgv+w4FvTiObV2tc+dtVR4Grm9FhdZbSx8ywPXPsJZ9DGelN6LDIDpiYYa+\\\\\\\\\\\\\\\/4sHAk9Im4WyVlBx0kA2S1peYZDywlHZwOrHYHYKhEwLf8sDZG7YtHjNtje5xLWl3+0CTg5yNPZOrvcxmOx5wDPMqMT5\\\\\\\\\\\\\\\/9m7A\\\\\\\\\\\\\\\/IS2v7smMIFDjmbJgbrkuCS1l+ErcXh0g7O3yE0tguTuUcrO6RRyTZ9esBvWQ2NVIhO41z1sjpCkwpXCiq8lfFzXsb13p2WM6haEPiLEfT0lQDp1t1rp5Qadr182b550s9hj\\\\\\\\\\\\\\\/aL5mDgyeO94SIAbhWrWlag2EHUnhG2nWlHWQC3g1VDIm4aC26FTAmRxQyicNzu5XDeRqNkTjfITFyrvWS\\\\\\\\\\\\\\\/2r1n512wOewBOqiM8E\\\\\\\\\\\\\\\/Wr5WGDV4+xr795wzqQWHa0tnCknh3ZQIrRiBAzskUcD9VmR0uh6FD9gO6t3++RvY9hC3E+AP\\\\\\\\\\\\\\\/WSzzNaxlBJt0A8ZZ3f7S+qiz+Jo9YACUxKhhZJllWjWn9a+qkBF+cFHtWIDVSLazB9UqELauuoVLz1glL06v+hErw9sVE5hViUjiG5IF34t+JFhApsrHnSa6ibdmdkn9QPbN2GRH6KVjE3nfGmZfkXrvYKSFxxxvLGbdIIOMwvnQyThjCB4U4ulQuCo64ueT7XLdBFt0zTHgqeVDIrcfuUtEKDZP+\\\\\\\\\\\\\\\/LtobxWfuCeUSaResRTwksZXIUFUbj7dfQv\\\\\\\\\\\\\\\/5j9GFeeKhcqxZM3OATTM5DhMUYuKm7kpnEGpvS2WOuLxkSrqjyLUNssv8Q3eB1cTW89dQkiTJERnhUgUJpeQIOoSvPdIATKG60NMMRTDmWHDqR5keJ2kCmlPdppZGV39WQKWW6qiDcIF0FO0cbMA3uFapY\\\\\\\\\\\\\\\/x20iYxtrnox\\\\\\\\\\\\\\\/XbUQW9TfTrkShZy7UMfyqoO68k3E2sli7PAofCXYvfumrmRI3gVgvwh2dO6tRyAH4S9CPIoYbdjpNN5aeJ2gzNFVZjFvVnLjUhBYZJji6+pufBxIcM0OJ3L3Sn9RbjKZdWPupehDlSPx\\\\\\\\\\\\\\\/R2zvnNFhoZ61QqOsSOdlqA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022xxGbob\\\\\\\\\\\\\\\/SBOwAPZngIFYwGg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229d3a5f139ed969d0e5bdd57f1edf16763b16e5c0965797e62a8cd1410f0322a9\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e003048.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e003048.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003048\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003048\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003048\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}