{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022nju9xGzU9HAt8OsYTThRlynvRW2Kt\\\\\\\\\\\\\\\/0AOfcu9f3M0jnEbE1s8EYHtGCcwW45reUL6lLxJ+yg+iHwWsf+vF7tVqcaT8\\\\\\\\\\\\\\\/0CItjWn3oVw\\\\\\\\\\\\\\\/G6f55IwrSkNOsvloHKRns\\\\\\\\\\\\\\\/arlz+lAgOqy8GPYLW8chN2JB5T\\\\\\\\\\\\\\\/lyc5ZMXls0VjyJIG89V\\\\\\\\\\\\\\\/FUZI0hgzs40qq\\\\\\\\\\\\\\\/G9rOTdTtirDH0sDXCMkQSk1+u5\\\\\\\\\\\\\\\/7K8KeR7dzaF4bX++qA9T0sCM8srvrpVJ5gRpFVS\\\\\\\\\\\\\\\/5UUdste8Fj8EZECkwr3NV0+eSpgJfBA0JMreFNKAyajMxdWM6PR5ODapuusHA2QioMfGCihdavkBSXjHq\\\\\\\\\\\\\\\/in4K2Kn8r7Ua3WK3uxPpCszT1A7Yto8rPIFa2adVxNqJmKCnEWd6oJxy47ua7S8QXouEXONUeiks0K2\\\\\\\\\\\\\\\/40Emlemt7RaX+X5Z4EfttgJS4lt51kPEtICT+KxjDCGbRcy7073uDiKaY\\\\\\\\\\\\\\\/UnCj4A\\\\\\\\\\\\\\\/OvQDlqIWIO8yWdN0mwpxxZuCmr\\\\\\\\\\\\\\\/bXOFbpatmfI6W8ztjCr1ljSe23og0XkoU+fnsXFu9caWy9DG5YpjX+BwP3NC67QXggssBDX7ppLAcGRy3OdL4Ffb2offk\\\\\\\\\\\\\\\/5bKakQPSnFL2vZmv8P4jVg7zvGemPNtzx82D8hje97gJSZIVOY62GclCVy+OrHEweKmXCoOfT2Bl94+M6kTg64ngQAEBjqDPzAOKd9YwV7yuB+meVF59\\\\\\\\\\\\\\\/P2K4iZpNJWExLNvbBgibo4uHuOL9RsCxT6xguAO\\\\\\\\\\\\\\\/Kr4ojtspfeGp0rqZApZci7LcM8FGDwzxIzEPaEc0EHA7RFc3a7WrbrX3Q6rLsy91JhDnrqHQIXCe1K5fv+OqpqNo26cWGxROTH24y1qoSIouudJOta+7fGqzg3i8ELLCX2hoC8+l9kuSqLNwUkYsniFvEFPY+w14s1Ver\\\\\\\\\\\\\\\/Fdxo0A5aMqYVtjUlTNnyCO7g5fEzDRckJ1qXzqFdFQ\\\\\\\\\\\\\\\/6ZMl6k2slqc\\\\\\\\\\\\\\\/W25QL3sjc+dhSAGXz8YBLvq+o\\\\\\\\\\\\\\\/4nSLkUp+poQIIqPN0rqJAG930lsdlHxNHZ\\\\\\\\\\\\\\\/ExGC1RcTpOxfOGDdkNNxJi7tk19EQrojcTfGg7JCTNZSom5YeztAj4qArt3YiKAtskCpDEV00d\\\\\\\\\\\\\\\/1fOd0G2CpNTUeBi2fX1RR8A+AAWxisGe7C\\\\\\\\\\\\\\\/xqdLQVVbieFwYILu55Yyi9VBzMq+\\\\\\\\\\\\\\\/0I1eJiKNsp9oDF5yMzER2IyfzeGdViqgtJ9fDGzquRDOIOtklck5jQV5IKHwYOzIM5OuBweu2SKtPR6psh38\\\\\\\\\\\\\\\/Sakvugj6VuEOkm4fH9P2LxZ0CS3BjL1T\\\\\\\\\\\\\\\/jlyLFeY759ifAWT9xGVeegUDTpjbrMpBcrGEcff1Y+lbgAu48GgILc6XtetJHEUQunwS6nSmzmxiehqXpfhDrHly1ny3JcONdgN3tnElOx37D\\\\\\\\\\\\\\\/dCGdjpxNfjlunh00JyIYoXZNRmA+4HIw3Kn3lyf9YyI7M6xvQ2+gdjabG4yZyFEdOZlx62vxJC4lflt8MD00jdwtqQh0LC8fwDnNPY0eI5JIBNmt0O4REs36N4NSXd0IqJ\\\\\\\\\\\\\\\/9EgAkZGzyaLVcq1Jqal\\\\\\\\\\\\\\\/IYzOCpVsD3tDFJrfAH9XccrkXgslXWHcQxmO98U2flnsuYqHsF8I8BY4jlJSR\\\\\\\\\\\\\\\/Gzay3uEFaTwImF2\\\\\\\\\\\\\\\/bis8TGxBjlJHmARVO8YZcvocDWJ61s7IDp9D+uSfQNfpvsl6kzLAujjbS9LC2i6qQfBmRqkgnrm+WbYQwUySx+GLtlFHU4TlY\\\\\\\\\\\\\\\/wtxqi+xGVWGm9Wp7JSO0d8kdyrjEdcfI36XDWe49Br+ePwhCORUOhlP0oijJ6f7y3CRil1Yg\\\\\\\\\\\\\\\/3jfdQ\\\\\\\\\\\\\\\/cD3EaUlK8mwUXveOkc1YYGlDIkwMOo0cw14IOhq13tnYcXqfoww8KbqRk5fkNxp6t7u0tk+4LaUy\\\\\\\\\\\\\\\/70jEfTEkfT5fpyjPZ+pXdlZMOENWmNnBagk4Clm5mFa\\\\\\\\\\\\\\\/+odIoTKOyaPNbkMyRVlHG0ucJvlYo0Vfdq+v4LsXQESVlPAM6bKTFTZztZ4tZv2UkrHimLLbK3is1Hz4Yypi3IU32nv0uGBN6ZKuU+cL+e80W7FhKl\\\\\\\\\\\\\\\/0x7CuUfQW0nLdzkFq3tlsSM0O\\\\\\\\\\\\\\\/LoCouLaktAie8ACLAb4SFHZzcePTFVv2LMvXVuYxIDfcZNs7aZ8\\\\\\\\\\\\\\\/YOMl7OJjmiucPIjGeCPEORrKP6lmgKx6Hhpm2ETjzpYU5xGdaAoEiLIXP7Zr4Y03wWZBzpzu28DyTBdRI9en\\\\\\\\\\\\\\\/VUD3kLMTK8fZ0uIWK6ihua2Gb9W\\\\\\\\\\\\\\\/GTyiWiLRH4qHkt6Z37H98ao6ljeS5ASngmOh\\\\\\\\\\\\\\\/JPagQfQQc7jNe1L98I4yqxEkJKp7P2MB\\\\\\\\\\\\\\\/PtimxH8EHAjHYfjy\\\\\\\\\\\\\\\/E7rISsTztuY\\\\\\\\\\\\\\\/lmQBjn4p8sa4XC0f1bgKIzlKabZRLLwHlSWqGdBm5dLmnyK\\\\\\\\\\\\\\\/A3UuFlW2PTBorgDbYFMnJLaURQkcVv7u25ZZHGlGGh5sUKAU\\\\\\\\\\\\\\\/bhRbKA0Cldy9TEP9dkUZ18N5Yfy6\\\\\\\\\\\\\\\/stchlFY7mZ2M5aGxVA9\\\\\\\\\\\\\\\/clWeIF2RwN2K5kfNN9ePd9wKSQd19UqaYU8ta1oFlP0olapVpVYn7jXidsxQlnuMjPOOQnOrMAHVSit+k4QikiPDTB9\\\\\\\\\\\\\\\/FTUkKFqhlNI2A676O+wADF9Tgw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022k5AOF3czaqYUKJnVl9LyXQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220d4fe348a878a4ba6112d55173c32cb176a50148d028f3157d8b5ba57d9c8b74\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002841.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002841.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002841\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002841\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002841\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}