{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fitqlBw0br1mBXs\\\\\\\\\\\\\\\/8GBj2JVgHCKYYEzbYB7NeKZlJrS+GQpc0rlX+jdw4l+fvTtZdRFJZG7TzDHu2Lhc38FTo7FKc9hZ1OAesk614KUbebXcOnf\\\\\\\\\\\\\\\/lWdp2wFHSWo7M9OIReh8IE1S7+bB47BEmmsgtMpe7TL5CHrsi62Mk\\\\\\\\\\\\\\\/5Os49X\\\\\\\\\\\\\\\/srxOc0LA7qsPjv8t2O5x4US2DUZqSkebmDREOU2KyDC2l2yDw8zZGYFtsRNB6PWB871LVRqbtxrm10zXaBxsZ1AparNoQ00Ixn9Hwvm4qmlq1h+bBIMAU0qz454ELZSXhr\\\\\\\\\\\\\\\/sagDemTsmftZ3X8YRNpwdMsdwGCyRPTLNztYOJ9hCbP5tryJmNz+miZkH24qhH9Q0kJgjd47EybVbqzAUqGfRKjrw8OKiyX2BqST80QUEzVqZAMThq7VB+AwWrEqHOv7LMIppowqTFmTTxk7TawiTUah+KOU3OVBwaNUJeEYIWYeTRJ+cgku8jmLS66bAwcfiy+eEI1PQtsP1CKxexaI+1JxlfybaxqgGel4+28ifsPu5h4nnsCFpEypNnu5ygpXl3eFcJXCD629CuJmw0vh+wWtZOuSftO6aHTgMdAsbi7KFbTFXLpi47Rb5Cz\\\\\\\\\\\\\\\/oXrjzwP2wbJfrMjIZcjM6CLmnJtflI2mDj2jlO4mENYgtuwrNFMWAeEMHp3bYQKdpcPb\\\\\\\\\\\\\\\/QrfJSgh4XiqH0+KFe\\\\\\\\\\\\\\\/FCOLLW74lYqDu6nxGhnP1AO7L+bx\\\\\\\\\\\\\\\/TvIYeeXsMLUvkVyt9YSvjjnQPlyqSpxo+ZyUCHzn6FNJFeyQnae1GSz3+o4xuO1HnyW2XALdzjP1T9S0H6N4uVgeboIPs5Az0jhDKIExgjbmHsuMLZNb3cZimrc5ISCK+1LWPmCWUrYp88BfPFPIcW2rqBcQs2fxC6g\\\\\\\\\\\\\\\/+3IrE4vtD4rB3m1gEx476nYF4XycOULc9l3vx4KVoOOC68oxXqkmKdj1pREV3j5aZCU2AsEimUrckcVqrkA\\\\\\\\\\\\\\\/bZBOkl9NRgPh5d2XFK39yQ\\\\\\\\\\\\\\\/9XyIuSIBwI47TOMboNZO8Cnq3Z6IRPnOFHkZGRamnHKyIF34hwOD0rts5TwEn6Qp5r4C0GJ4sIz3a8Q\\\\\\\\\\\\\\\/H3LPrByH1+1foMrxA4UP9rVjNQ0Z7aa9ljGsleTDct\\\\\\\\\\\\\\\/WFOSPPwFZ0JEeapIF7PgW0YqETXcP0mVMlz4U7kjlnILxw4jQdPGxJWI\\\\\\\\\\\\\\\/apJJrGKFyDz0r9m3fG7njNkStvad1vPhRc6hI282KsrzBj2IdawwQmWup6Zqqzm42OM1LimjxttIPiA0i\\\\\\\\\\\\\\\/W+T1NKPUuxDUx8miuUpJYIL2jHsgW7p69My\\\\\\\\\\\\\\\/6GmpSs8rv66ao4NBz\\\\\\\\\\\\\\\/O\\\\\\\\\\\\\\\/ChXTOaPwi\\\\\\\\\\\\\\\/3WhWiC1U2o4ytsia3JwcyVEVgnoJAUXWvj\\\\\\\\\\\\\\\/q2DN5mMpFD78r3yEyjGKAkl\\\\\\\\\\\\\\\/HFQ1xUHEBzBjEXTRAaDz+d00hYBzvUVL+FUOSN2hQ4H0YPhM4Qo7zf6hX9y0+brTveXxbti\\\\\\\\\\\\\\\/gq4lEEsqNGHWntTSREPKXetwb9lgw\\\\\\\\\\\\\\\/ymwL3ZG2GeOxZhvmZ6w3tbYqc680eVWsI++ZB6hEKf3yUpyjLwZaDvrFCtQCn\\\\\\\\\\\\\\\/G3FUNzrQcMZuBJjknq+UrfGjGrRVPXkSb\\\\\\\\\\\\\\\/lQvO5W2hi2SblZLGf2MWW2mo4RpuaCgdQl0Ex9IXzjl8vbjAAwaRkf16ZFz1hkJ2ceaIGD8NI5Oy2w8h44TUhi2OWiEmgWEWs208\\\\\\\\\\\\\\\/z1Q2WaaD9xHEIYj1G94gvOdqMBKOpHIoz2oTCRucjoG865qoDsm5MkXrQG\\\\\\\\\\\\\\\/gbf99EEm+obg77G3o\\\\\\\\\\\\\\\/CzXrYYXb9i46sAhJ41hBYuiU+uLhEy\\\\\\\\\\\\\\\/vjZBYvESE8tawInblrU79dWPI1X8SokothD953a21bjKAtnPMgrk2uC56zExo4D572bVnu9Qro5E9tPIYQVtH+AqlFOluADI\\\\\\\\\\\\\\\/artP3R6LANLQSuEzRVT7nGjeQZP67MyOEH3blYmEe7Cd3lS23djQ4IBtlZ5nz16oh\\\\\\\\\\\\\\\/Ce+Cvnc2PYADdtZdATiQlR6tWob5buycE0GdhC5\\\\\\\\\\\\\\\/W8fRwJW4DWFOMt5hgRuLpCyzRqEdqBqUF\\\\\\\\\\\\\\\/mRAt5qA2i\\\\\\\\\\\\\\\/KA1KanFWYW8e\\\\\\\\\\\\\\\/YTSLDV1CJGidCR+KNKAoiSKPXSFW5oJ+3fgRThfTjQoH9zX31CqG\\\\\\\\\\\\\\\/6obuFGZ4cBBS3idKJKYKPXjLH2n5CKN7mFcOBnYgda0mFjRTBwbyJCfDzL4q\\\\\\\\\\\\\\\/Wv65v2Xge1PKV3zyus7DDXhDTyMR49\\\\\\\\\\\\\\\/zFgkLne+JEK5MoQdBFLMiJ95xBPJCmNSEbewD8ErfxsDkxOBBuoen4WWcfazYF+4OpZcu\\\\\\\\\\\\\\\/VK7g02hp83WFzHgRZrRh83crwBtqbZqsnAZLfBOOauE4AGWSJdA9jDDOm27KsWePbn3db\\\\\\\\\\\\\\\/ATgKNOR1FiivOHk3ys+etRYqfbFNoW46ofMXHs9dEVStCfIN60W0CCn521d6MwBpJOeFyFOlixFIm5MJHdHW\\\\\\\\\\\\\\\/7aC3QD\\\\\\\\\\\\\\\/tdxp527pVLnwF\\\\\\\\\\\\\\\/Po8wMIN8mvjHjigaVJBZs5JR\\\\\\\\\\\\\\\/eJbJpd0A80EKTuuVX5exKc21qJjslqSePJRnM0m5Y3QWqjz1xIWPG47hwhHihRUtDHtifH\\\\\\\\\\\\\\\/j5OB9kqWucuX844mSpaYJhxwWJhAMc4P7pzLWRsFk9ENPge+Hc7gOeU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022UqKdu1zR2oTkXrZA\\\\\\\\\\\\\\\/j3nwQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b11bed99452b7e7313cd8c944d820a7c9be7e06feaf3f50833eb18f59c7699a3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002454.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002454.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002454\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002454\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002454\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}