{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221mLLF0eUmPQ0EslP5xtgKhjX51YgqUZgAIbOD5Sx4VLVWtzMvyipqxVT9EJqcWgQeshbs7hlOD7ksdG94aJa9bJsm5vgtYz4lpVmTyarhC4IFIECb1nLdanrPkBMD3O8Z+hdiJXeYEBsM3y7+AxHLrP9dkY9zODCs9bLp3HM4kAXF\\\\\\\\\\\\\\\/bwwak+msilHMj+3RF424r3LnNUHUjV4GDaNCOJuDaunGnISF0mygAqytG14x7B6VV7TuAkwYMFUldTJjF+5E\\\\\\\\\\\\\\\/2rWfyPqtSkE6tH57sl0CzJ6b5Ep3I3skxJBCxl71+RCTveDwe4P9Z4uKOaUi3Usfsc8SLCQEWKy\\\\\\\\\\\\\\\/P9XMKAcJbtg9GSP8vr7pDPOlgK3yi20ogmLzIFwc\\\\\\\\\\\\\\\/88+gGerpJLzQwNX0j98fxaxhmH9pdCd2Ucjoki64fXQ\\\\\\\\\\\\\\\/3mAcnFMilD1eFdyed\\\\\\\\\\\\\\\/hA95+8Mxqsg5mU1wRSWSlDVImZTgHxelRW436c91r06vnS+hYvyteE7IoeIS6j9hV0PN9MF8FxQW378bXqqgQSqIINQ3Qb04z3WPhH8s\\\\\\\\\\\\\\\/Bxb4ItNxJ5CJ7P2GZVhiNGqVD3XlMYYtwcG0njMzrrpIwv3SXuolsSL8UIvCdtrgyLKPvaIDYIGOqFC+nlsYeUAjHFoNGUN9kIdpjMMS9byn9TCubnHSOCh\\\\\\\\\\\\\\\/sfgHONCLOSloK55GJrmgLiNCowRk8IyhaYqFQXriByOGPrTrJJw2UuXxZownjnKc1ugW\\\\\\\\\\\\\\\/fRRPO4uTbsjasd4bxn+dN\\\\\\\\\\\\\\\/SybQLRMMYdA6y9rkC+s58XnTj\\\\\\\\\\\\\\\/PC3bPIfY6lw7tfQVpucbagcDzJEhW9+8KPxF51CTDYwJrOLuu8Pi31bhBcn\\\\\\\\\\\\\\\/aD1sEq4iNEoozRJ4aownRq7IV9it3K+UrQaGH5FtNsHAMvaBI0w5vQ1uTqf\\\\\\\\\\\\\\\/paEnfJiEsgBGJdGfKuEc\\\\\\\\\\\\\\\/YNuabfB7xoMNWY0FYTJkHhnEZJt+meLKateJ+wio7hUEIXrjAQM+0M7fDoXCJf25oNwSc0EW2Gxik6\\\\\\\\\\\\\\\/aTgh17zR+LamzJOJLUiJEYVDOnQn6qZsRRvigoaD7bxvYMhKB+OUklQPzau90Ce6h1z9hoSeULMrqA3ouYMizKZDt578J1CaW14QM9SdqfUUkdAp24af6A8ZDo7I\\\\\\\\\\\\\\\/C6WqkxgxcIO3jc\\\\\\\\\\\\\\\/tNgPwacJmuC55mMRqlt3Cw1729OujwHZnXH9I6hmDb50Wiv9DBsP55jQXvOb2WC65yFzf3es\\\\\\\\\\\\\\\/DgthJYGqMYcRskMTXPg1724BPaK+I5v8gONWone2N2Jqjgn+8Zd7CbMYXT7WF9drpItsCNvayrYJLfLXK9D+QRZ7lEruJnXcK51GLZGI5oqS5udcEhQk\\\\\\\\\\\\\\\/buo3Kb\\\\\\\\\\\\\\\/y+O4iMyrVX02Xok9VCraUrAXDCL7d8NJ1WKM7D01UYExKM86++x7ia2akkfbxn9TlsVlbo4s0l1jgg51qE92lMOQ83Jyq1d6IZL1XXKr1gxQQ28yR5hm1Jrwhns4q7oA5f\\\\\\\\\\\\\\\/j\\\\\\\\\\\\\\\/IMAeX\\\\\\\\\\\\\\\/Q7AnCd9BlAchtbi++sjL6jZ3TzJTt3OV3XGPTjMAtczvj\\\\\\\\\\\\\\\/llRlXYCn11FKd2uYHBrPc1qbbvTgNW0r28mOfxF2t\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/0cpzq8OzbEnysPVpTcpLCS7+v0hstFf0mAOr6wRdxCiglx63rfaZi\\\\\\\\\\\\\\\/V6TOKB827jZmg4Auc6qxk0Y2cGEPV+ag05pwYWHwsW+k1UXOB9iTI79d1oJvFOCjOmg2il7Zu7IhnzfZDdjiN30tBVQWEs3WbgQm2CtUtfxNAHWuiIK\\\\\\\\\\\\\\\/yg\\\\\\\\\\\\\\\/lHyU6rgPYd9rABW30X4Apgp+rs\\\\\\\\\\\\\\\/hhdNz3UYMo8JJqvqdNxwCg5dXcg6q4UGNgvWllWpQb9HZDkgQem+5szV2OfnVL4pJhT\\\\\\\\\\\\\\\/zaGfPyqpbmbSh9cZMHPhsxaSrPnHiTW4\\\\\\\\\\\\\\\/oLGBJL8M0pNHs9dPhXukIzb2euW9ZDttNDrM9eZFe9p9aNh5dgvKZWamv6djqrMtRRuRIROJ7wBVzJZglSbDnXj4zfYTotlsbOov1SXu3yPZNWb46O1e2Ejfk8uMz5pyT+Esb1XZ1s7ywn\\\\\\\\\\\\\\\/4hAd9BN2NW3ywM7\\\\\\\\\\\\\\\/3vgr\\\\\\\\\\\\\\\/N686yD2z1QSdxUT\\\\\\\\\\\\\\\/Saav2i52TdXHe\\\\\\\\\\\\\\\/jMw\\\\\\\\\\\\\\\/n0LdPrwZtg\\\\\\\\\\\\\\\/pEdgbBlixWIG\\\\\\\\\\\\\\\/3qKcAkDf\\\\\\\\\\\\\\\/UJR3hTmDafY\\\\\\\\\\\\\\\/aWup1KFPty5u+IUIeuk5TgBRrND6SOnJEy13876INFHc0KkI+wUhAUeQfLpM8HIpgfXFaqbwzCxXgORjhFaww9kZ2ITwN9uWgp8CWj9tg3Raec619jozXIdYFxbjtc\\\\\\\\\\\\\\\/AUO3U5UT\\\\\\\\\\\\\\\/q6vyBivExoPhHLt9eBxzkA4ophRDip6YJTNuYreiDMkdDblZRFqTjFrItFaCwQtqeCJd4CqiIPEKlnk3kWHkpJ0tMfiUl00nRZCxKVK1eDQT2e6\\\\\\\\\\\\\\\/ailYR57kMjNHKz\\\\\\\\\\\\\\\/9r9zw3J\\\\\\\\\\\\\\\/IvkT7jVnfvqb8yfA3Vhc4\\\\\\\\\\\\\\\/cdMwm87HZkyj6m\\\\\\\\\\\\\\\/RfQxUouxwcJebamQ+7BkKXe3yKgVW8oda8+FkudWFRU4YSI0yvW\\\\\\\\\\\\\\\/Slb678\\\\\\\\\\\\\\\/pxf94zyYuCUR6Z\\\\\\\\\\\\\\\/4D9GYZFsY1UJWuTVF2HSlg4qqstVzMoN0UWFoDvWHwBMKIi4lfJKCVkgu\\\\\\\\\\\\\\\/rRPaYM2kh\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/GGd3arzSYWrc+0uiDueZxD5oMqimmRBftnCxBC0ossY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022sj21UnoQvBHsUpIn6AhYqw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002220db2af1a8c4a6c9459cf7862a40356e010b3fd11155344fcb8c8822a841e127\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/7\\\/e002703.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/7\\\/e002703.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002703\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002703\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002703\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}