{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022343tzZxPKTnUM2SOVfLCY4oNqtrBvpn9LvaWEpN2ZKBC4hMeadFyfI\\\\\\\\\\\\\\\/NCL3KEoVQEcU0dX51mExDlCcCb4G31HKHgVu+mvNR7vlFqgrJvZP5nxRi0m0r+wF3f5PGdEZ63Zq2oyPgmG4KBlmv3r+IIo5nCbo7qMiXsqrBZv2D+c0XmEjrNdjTEWTjWZCQSI+SVY8gNrDv7Jp1SGluGb+KjoY25DPc21xmzRM0O1oX0uuu+ndvw5\\\\\\\\\\\\\\\/al0k3sX9rY08\\\\\\\\\\\\\\\/MpWBSoEezJft3tVH5OwoIhO+8jAXKL0YBhWWYUCldaaR4jtm8ISKaqxcM5MAC3PW\\\\\\\\\\\\\\\/2tVV1WsviuNKoYS7buxXHDt3yzz2ciZdK2WjZmTAOJtcs5BQPVCdkidIJvVRGbkKPda6K239E1s0QWhbkTnTpUKMtGM+YYtlVJGBVHezvdHcGbenfMz922Ua8vFI+czPvewRMDHDoVXBWYxeaj2RPC2zxQ+FJcuX2xtKjDd6A7W9x3RQeLU+5rNW+hwYwxCrMMEXoTjFLlQf7yG4vRRmNJSCW7heivzX6nbMip8lTKARfUArWpTXfAJTxbhE1\\\\\\\\\\\\\\\/f9+sPAsLVuW2il+b9Y4SSsCipCccaZlabIFhz+GCbmlO38iIQ35RGleLpHptqD5\\\\\\\\\\\\\\\/77EwPI+4VRV4diJ+PJ93W4lFruRFqRbNOzguknmgKzc0+wVETF+8h0OnNR5c8wiSoO\\\\\\\\\\\\\\\/FK+663OTLaKvcr2qrqJ8DifruSttMPQ2dj2SmSOYu92tIfryAhaIYaXUr5IHGq0cV6DFXgYvg\\\\\\\\\\\\\\\/yM9Ti0IhZAg14iqKFywn0W6NrTYKhyX8hbScvnupRuRgglSuByOVgZHJhP8Aj7njHtG+NgA6ALlG0Jb0o+fTvt095OxpR8JQAgmBt6ekbIKoKJiYZyYPTafCuulsei7e5KZjEC5xlEfzQ+DYb8AtooqTACEhW6uO8qWyxVsj2aTpTlmlVGNkGlbInNl0BuvJdE5AFPt5F58ndZWVzDGUWEmknvIqrqtSD2TI6pFKcW+1SLXykpqPA4sln+yL9ltfHMKaa1JiOMZmuRSdLV\\\\\\\\\\\\\\\/oGFWWe4I3asoPJSInqDDhTO4IKLtgxlDI\\\\\\\\\\\\\\\/Bdp49FPbqxfWxb4xU91B3KVNKzY4R5OWkh5KMaouI2eOuRHdlViN7TRW\\\\\\\\\\\\\\\/8mS8eM56NFqrOyBcN1LcPjPbmMULq5Ja2\\\\\\\\\\\\\\\/PqFEz1618uucnBUoscx8WVHL4vU7c4ohsdzHukHaIyUnkiCon5aZVgP0P0\\\\\\\\\\\\\\\/ax0KIeDmwayS0BAU\\\\\\\\\\\\\\\/hWUrHqki2rRRbnEfxfhx5LisHIuMY8TCqr\\\\\\\\\\\\\\\/Q5dWVN7R95COWChwKR9I4TqpMissbbrMXAdtO2ecU6q7L7vRDZ+xr1UNRLyJn1DLT843flx17cYUnsL5mPsKu43QVsziRUUWgSCkuN3qORJEDSMLm+glOoJFhB7LEuXYj3kiyRKXWie0JAN\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/up81G3vhzkramSgtroIIJjH4a\\\\\\\\\\\\\\\/xYWYPMaDTVFWCeuyxvkp\\\\\\\\\\\\\\\/pxh9Baqf08UVg9foeGrewVzmujKtMtfPgCEF5kYKlg5KcMdYHr8gD7c2hOysl5IIxfaOMhuGtPRmKgqPu19IDzeY+RA49\\\\\\\\\\\\\\\/tM44No6LYViQvRgk+qBAr\\\\\\\\\\\\\\\/M6eIZbP15APM48eooa92C5NQLO8ptke+QE6yWmG7qPgthDAazlpMJHI\\\\\\\\\\\\\\\/q7XYt4mLD8W9qejgPBH5sqcapNQyA8ZH2lxKLMuilGk9qvp77zz86V5n6kO1QZhtL2n3+BxW9KQh6fk4+etMw6qQoG3w8yUkR1zKabi9VGe7vCqnWbPzmhVLGyJQWSCDCbKodfO5sCjqE\\\\\\\\\\\\\\\/mf2ltiXxidHZW2s2CsNpieZMEFO\\\\\\\\\\\\\\\/QbG6z3mdl6s1CCJ1sP9EmjFFQfL5J2Y\\\\\\\\\\\\\\\/HmAy5hCjuvtCXwiwp6JgPCsnY2OkqrktflaFqsNfZ7Qk7rCaZF5AfEE9GFqe2lcSXCmlkzOU2v0t4Mg0vbM2UxBT+H5+v9Atmpst35bSVDFLbaI0\\\\\\\\\\\\\\\/C3cWWCwvtuTaDCez5ZaQKbiaLXPaNV36aQuQoXkRfN4h09bdu8LcwyulnNbLleSO5zp3PVHvBncRFrrchIEHYljBKL9TWIVemxIUHpGb5cniH0PdxyLs1Uy\\\\\\\\\\\\\\\/ey+z\\\\\\\\\\\\\\\/7W9QezA\\\\\\\\\\\\\\\/LtWuu0TbqZrgxDLRVf2PcRMdfNNDrHSxGMeL9SddmzYsxRKDM1k7U\\\\\\\\\\\\\\\/y3pWepqZpf4vXvDPyiIpd6hCyrctxZdIxfNqxGf0mDhE2UMWKVdwc5JnVGWQw5Jm62U\\\\\\\\\\\\\\\/3G6joPoB95qRio1x7A7KydF943fJInaN2p8sXsfBeWb5qzA1uZSzmrpeZm54Cor96W5ChTydocyncg\\\\\\\\\\\\\\\/6dDHpPISIzm5M\\\\\\\\\\\\\\\/Lnn8auCH0TLX1liF6idnLHEGYJw6dj39+kU0kC7oRt+ZgEbJXiO0AF16mEf95HlWt6hpB+l4WasGqNlHjIieFPZi\\\\\\\\\\\\\\\/AnGFkfrxD3IcIOuZgE4kgUWWzROEGkNv5LMM2uwtJlRwOLW1uDkTHQFjjJxmI1Sv4z1DH3uH\\\\\\\\\\\\\\\/Pelu2TUNNRdIRYORJsDLK5jZhSfduM0380dfwtoSx9DD5s1ry0eKeowanw\\\\\\\\\\\\\\\/qce5Nn67PGOfrMtpICgqkIU3XgtElw\\\\\\\\\\\\\\\/GlWcah8PZzyGaShEV8MsdYnYCBIMyHtM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022E7GmNW3+rOGReEQ12AWvew==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022078e93a7b25cddd3cb793d3271fa6f3dfc3dccb65e997fce488f98d4f4baef37\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e003138.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e003138.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003138\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003138\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003138\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}