{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LrwwZVqP5qhZTrMOpnVYwbY4ebP00FjjV7TBMzAG6bmWYzPJIum+9mUdHBrsmykKQiIBYGZoJNgdSG4dhzEyCjNelm+KNJZzBRg0wF0hxUafeo8DQmF7IGiP1CvVT87IhkjOD5LDiWfrn+h+Zbd8\\\\\\\\\\\\\\\/5mNs8L9qLqZtOEhg4JFaI3IkwHJA9Q\\\\\\\\\\\\\\\/9B0Zmhn8lcn+5BsmFu2oTn4oln3l7P53KxJWVjuzcLwmfhCTAbLYaW3y3wjatsYePsho3V8+EFCv8FYbycFOJKdl2Xe\\\\\\\\\\\\\\\/+3RkQXe92PsfptnMvyiPUON2Z2a8CJUBZAknBG2qKWu2Ypw7vXSWGCo+nO0CCIqmTmw4Mll++kTngLhJToj6shVljeWG4L6n3kbaL0IBzqS7wnX9DhDtgO7NkoL0a3cmSHr\\\\\\\\\\\\\\\/u34Sng27fAVJ\\\\\\\\\\\\\\\/nk1wHTwEGDyzXQVhvl0wTjXUtnUlrNs7xzToZOwMkl+WML5Zfi3OAL+tXRfXxr+H0txVq7Gn7DQ4huUehcBAoxHfbpkVM645XKhqUUj2aAmD0AlP4vTk6b7o7xET16iW+xSxcFhxC3XinIP4EKBO3XdHHJRyRAM6cNpFs7zK0U32r4MSQ\\\\\\\\\\\\\\\/h4MKwuSWA1Nua5qaVCROrtgJ9KG7rXtdD1kmFNHYylcYOYNCfQ2GlvpOaj8XPjzdRkyE0HTcoGZa+mm+XyR8THFDsqH4puMQIonzGpWXkHaEDE+ZzgDUGo6G\\\\\\\\\\\\\\\/aQjHh9A6Bb2IrstFYRyV5kCy6y2f2lzJZm4nRap7P5Y0rUF\\\\\\\\\\\\\\\/XqeHqXT94tRmz5P5BsPv+5HBCZ7UO9z\\\\\\\\\\\\\\\/pq3i2r8aWcVrwQv9XISccQPhvmcr+8eMp1IUWhJuNdY\\\\\\\\\\\\\\\/SQHP8UyLdSDWgAqLQTOP6QuCIkB0WfI4k4i9gv5vR53wzBSuOASiQfSTPNcLxaJ9woKOff6mQMQKPkzYMicH4q6r7mDRNBTJHkGgoNvwR+sJL64su8A8ysAqoqCUk+SzfoEdI1KZ0hG8\\\\\\\\\\\\\\\/xICIkBnfDfu4Pb2pLW2CBKeRNUhU1RGHZafg3woP1paqNlfQgeuo4mLZtMo90ftFUkMzTgGlsPnoPq6xodn0VzmARaJH420rUVXGKN03ruQPI1nRVbEvPaa19u3sKiqTpX\\\\\\\\\\\\\\\/Lmf6icLO2ekVwixjyrBU3RQs06RslTFPfon+EsQFqR1QIMY\\\\\\\\\\\\\\\/ieEnA7p9MMhpxaJLWrbxyMU+q8etZXwMo1DjeK7wjb\\\\\\\\\\\\\\\/tggAG0PC+PryBEUJIyV5AklXKAznO+a1mSsnXbMLKoE50Fc7oDiBtGu8ljy29kJoAMV36e9o9WeeB7G+Q0VgkNHGvzvHtIeOSffJTBoFVTaL8a3DQPHpFcxyxv7+cNdmaiyWDrdMl1FhMrlOxGCa0Q8Jr18ybnYBOhE6ccdQfNW+5w289XRLAqKtiLB6OH\\\\\\\\\\\\\\\/9wuM00hr+0X9aDmsSp8kXL1dOXdYpw+6HnzlV0AtfUeezOVcWX6Hja57z57iCjNB+lvCnmVD8LY\\\\\\\\\\\\\\\/VJJ03aP5irbj8+FSWwQOtt3BNb0rsTyxeaHzDIRxwYAF8Cw2yBhy\\\\\\\\\\\\\\\/y4zdLuRIFqQzsnXdtzIYvhGVmUlGjD0OMl29yLHoGOp8sSieg6T1+u\\\\\\\\\\\\\\\/rkGXP+QBg8e\\\\\\\\\\\\\\\/HsP4morIzfIC0YInrtSwIW5NCFl3RO96vVPL7elRg9Gq11P2p\\\\\\\\\\\\\\\/Z9+++E1D6WpH2Ev0n4Ehtc8aUNJDhzM7F40VM+NKfhaOd4cW3h7V5BUIgHEWTXEK7lLHVugQF5ORzKPP\\\\\\\\\\\\\\\/oRndb9v0MY6QvFmZ1xvEV2SbrIstjxZ9OlpGlQyI+QhVxtbxrbiBw0LjWjNO\\\\\\\\\\\\\\\/JLoKOnEmxfNjimyxXOxFFt2tgFiHXlJJEOL1AjYIBWdE\\\\\\\\\\\\\\\/sFHtT9cfneaSSFEkl+9MgZJxNqVaseGlTzeS+Ujiv4uK0wy+SLeLFkRTXFOEHFe2HmmedI28NE2UWELLWlFvHyVNo5+Oaqfi1v\\\\\\\\\\\\\\\/3SaOOBbo8Gd2fjWzVMEIazHrRBh9ycu1a9Y696oZiVgh2l9XybV8uXCKnDASjaCZOStUgZhsKXaCqTcT8h0p6zOkyPayciMIWo4j2BTZGn1TOg2P2D3lQb\\\\\\\\\\\\\\\/nyDj1NsihMx8uRrXZ1F0H+CpbQA9f8tau4I7b3mprKFDnefM\\\\\\\\\\\\\\\/L6n3uIzs5iHtyBDDF0xMuJsypZdHBN5Y5CqN7q0MPBLPAnFjWqsttCz7FySGwphxUW4JZGUhcX0rYcuOn0XmMVFq+MIRvGFgfrwSlQ9Mb5+gYwe+5yax4fa78fEA8JoadRywhFPvhRYipg+J2AYQ8wN7phwn5cmEwApTbzApRg+mTl3rUzNcazCweh199U7XhqNaiG6kgOJKb2D3tMnv0tm8GmACgQftQlWxR6wirU1dJYic0GIjKOTi0z3jD9S4pToo1rlIoxzyzujQ\\\\\\\\\\\\\\\/brI6AEj3PbsQp+GtmOn4+0\\\\\\\\\\\\\\\/uoElszwnwdY4N\\\\\\\\\\\\\\\/dPf9mJe+BCQTB7SEVZEfGfJTxaOP8geJt+9E0xwktW6hBzca+7YsSBSCS1lUjwEZznPloAvEb6MpeZOdOGPUuqxJZPmKQ77w6i78+\\\\\\\\\\\\\\\/zJRShuV+6K41yZpLt3AvIfvvyTaJP6f\\\\\\\\\\\\\\\/NpS+LPN5i82lrtjKfZAUVNHKw4Q2HfNTnuothg4dKHErjyytIxaC+NfoktCjfs2IE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022p7wBi2lL2Mr3BZrun1JBiQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022286c2802a1ed09a692778e73bda9cccea43f5fc6a4d4219919b71b867469c39c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002771.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002771.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002771\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002771\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002771\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}