{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022CJTyal6QJ15lHrOpICT3W0JAm5CRKISrTrX5XrLkhc9Ro9vbEluFDaCM7GjtGHsBiTgXjZT5WAExk4h64nHnlm7e8IeV9DspH6szDHEXW2F3Uz0Ll8NN42u8HU2ji9HLA4e6nfeA+yh1vlS9dErw9EwcEkPoLFpDWc2I8YmFRsKsKBZaTEXozjdrXXJpTbY31yuR5giPLc15tPsXvmPIL\\\\\\\\\\\\\\\/gAQxW8dETPbaXp+BuBP5UqNyyI28PNDjimHTc1\\\\\\\\\\\\\\\/EDldCnV2qS2Okg9LKX9ofWToKStcr3RVYswCwc8hbZoa7ckVuVAbhrfakJdXzcyM6MvpE1AJdTQNJW\\\\\\\\\\\\\\\/IxO9dDrfl1Xj7md+aCo2\\\\\\\\\\\\\\\/Uir9b3vAEAzjyUMHRaUFU\\\\\\\\\\\\\\\/d\\\\\\\\\\\\\\\/LD8YJUeh3XWYuIyhFfUyjpcQkcLHeik6NkbCIdqlTixRU2C\\\\\\\\\\\\\\\/8yHJTjUl7Tr291mQNnreLpbwuE0MlTYuwjCezrIrNmepJKu4qU\\\\\\\\\\\\\\\/cUZEPriyQy96Rsu4tEhp0zdpUsM3UusWOnAB92LjnRkCivJZ8\\\\\\\\\\\\\\\/UaYPP5\\\\\\\\\\\\\\\/aasPCPEqpdMgwWNiLk7VbQ7J5yKKOdVP9PSdoXh6QkV75NmK2FoJiZzdY1FV2277VM6+lbiCPq\\\\\\\\\\\\\\\/hTFrkn8y+Ee3ATufFccH7NHJZkE6TLg0GlZozj51zd50WAsNlresmQlKeLC0oRXqaP9OfNc77bA7RE0AuHxnhQSDFmYtHOyckDbfhO7opj8idt3I+LMi9x2ZlktsBEaMVT82rz5ZqqEjFp4iP+dYw3QlQwVy1OBGvc2samuozvEsgoVBih0Z2zh6yQxce6Wzpl4Knt5PIPEZPBSrGWhkmG+DQPnO8r0mUKgh9f8ctq\\\\\\\\\\\\\\\/Xd0xehqtEgsT5sSRt2crskLisIZ7RZnSNnyyEKRQFVXiP0gs9RJc01DZLQ53lvNJ\\\\\\\\\\\\\\\/2Xt9vzRplVH\\\\\\\\\\\\\\\/u2srSy2wuCMpt8r67E9K+1e9nhudc1KFEkzTKt9drc70Ig31dhWavq9EE30DOe0SPXQTuP\\\\\\\\\\\\\\\/E8wFjFbZ03s3U5+alLaaLlMPb2IiQeZUc2\\\\\\\\\\\\\\\/c9R6tqExiSWdQuQRpArhwAf1beZE3Q4RRrzY5N+htdzIBNDc6e9dRbwsnrqbK6HHDoXeGEtVev1OAY34U+fa4frFKCkn5pe5E10OtjiFBcftyTSbZYo8acskvQm5+bZbOnwf3kyZci5YQ6zYmpHKEljY8K35OZFb1sh411kyLg3P0Due1vd456Rje8JFRxIy9Kt9vmwVkfrP5yyNnIRuQlaQY3BEY9c\\\\\\\\\\\\\\\/xtzJ1vjQurZeMHTOLPE46wpSrcL9bSppyLzxgtA02jG\\\\\\\\\\\\\\\/pU0wIjC\\\\\\\\\\\\\\\/gm8obw58uCH5SGCSHu61wbFZ4ck9n6ugS5ccJIx5e3fUXkL38bcR4zitgLLKWQBUGX4VasfXG06XEw+h3XHAlkPU4j8ODOzkduzHD7Ut5POsMVkTixICueEX6LPsHyW7PiHSbvu4VZOqV9c\\\\\\\\\\\\\\\/QvqEc5Nm9Fw9ZJ22icPA6UoCKfNzd6uGSTdZmZR7jS\\\\\\\\\\\\\\\/5cDY12C1f04KYBe2ysYMjYlJr0SSS3OAu4l9+eL97K\\\\\\\\\\\\\\\/e3fnjwW\\\\\\\\\\\\\\\/I9OfS7iV5Qd4vzfh8CS1rPEfSGT3D9IbEWr\\\\\\\\\\\\\\\/Oh1p5e8ObWYhzlc0ccd0t\\\\\\\\\\\\\\\/UA6M3Z8wU660VpsXYhS4fnBQIUix6Dpo2vVW01F3\\\\\\\\\\\\\\\/Q\\\\\\\\\\\\\\\/EsiHLn4KIK8OOwR\\\\\\\\\\\\\\\/j8Y1qEVfDAw4sNrBrquHySEgVNNUcheiepmRWcF0o56AN2FzPuHpdkFPY4oecmEYBymJ5KDlrx2hC469Z52QC7HHdANfuvf+IqppHDzwgIXZlhGxT4Pu8HQsrmLRFd75ALDwFkGqvD\\\\\\\\\\\\\\\/1zyuGDnYr26xne0rEoKFOfk0W1z\\\\\\\\\\\\\\\/e6UeVNd4fusnuv4FgGLzugB4OufyDqx3OltJ1CnOnn0bGCZX9rqWCM+Rv+KttcVCulDpNVyp6arphGVcy9s5jeyjqz1T+c0tt3h3qP6\\\\\\\\\\\\\\\/U1YLP5\\\\\\\\\\\\\\\/H9VTFjuwhonQ50Idsbgz1dSMBRV5Gy0Hp+TfqUWnWKYHy9a3BSCQGWGqZP22vSH024+zjBYkxn5yrsWxfqJrwKcMmPOlA397KWAVAO3VfTChhOgWGltKSBadkznvXpbbpnu+OEh835lncoRhEYvEKKuBEOfaj0p2mChB8znCIKj6tMgfNS4AQwJViiUKktwmTvKRAWQPoNA1JhZ83yhBoNGBivNfGfxWwTtzOiGYp+ZKc33CjwzP+gNUlTlA4HeZH8XAV0PprLJzcGjyaoCACFVJUtXgk7U\\\\\\\\\\\\\\\/vfVTexhvtej0pAUPI8F87ziYAiL4wf+ua+NsPhC2utg\\\\\\\\\\\\\\\/7gKMBIigH6Wzv9prIEiULS+amsx4zzdNrUodGMD14rfzYArdTTMzYdh59gsZg530Rgy4Wap7gYtyboI8EZnjqzaqNs1FEnvYf6Uag7BRh5Gy6ooDX04cmLGDOkkdIpEpDr4R8KhV8fD44xu0EG4U3eUo5gARl0vtnPcUygopAvOPrUfNStYGr7vifmdybMXvPCnHsqELqtvMA1gbL6a4JSV46ENW142Cukkip6uFb8hjchDP2+DO\\\\\\\\\\\\\\\/+i6AAyu6TxQprI1+F3yxFX0efWSZoWZ9rQD2Kw2TIlsgrbmz+tamvMsdhJtil8J8eoFVQifR+87Rr52b9vOB4fchtEI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022grgNqrIo2GMO+qJaWonCwA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002233bd7f26e91ccc7d33a7ecd3296df8f213c335317dd05b58e2c177fc0ac3ef93\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002771.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002771.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002771\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002771\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002771\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}