{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022NMoYaer\\\\\\\\\\\\\\\/lN9m8+yyM+iicjyplcufNcyUJSImEzl6XNVSlCvqmiAm9Eyvmn09b+vgn\\\\\\\\\\\\\\\/qVs1OtbMJw9SsLWzfojm6qf7RowdnUA07Q\\\\\\\\\\\\\\\/wURGKByiU7GC2h85LpdI931gN+tY00FE+qnYLMyIoFIDpnZc8YJLylW6TuuzW4yKfi1g28cTalwYzz\\\\\\\\\\\\\\\/T8Fva96jbz+34STSF2uyT0PoH8gihx2LOq1ai+hbkGkzffZ8xEQiUIcXDd9VuPzoLAV9DYHRVqWswi6VcZ33KVSUwcW+HoAJp5VJeRx\\\\\\\\\\\\\\\/14tldlL4b8Ec64A8+kQdUa6TnMcCVYP7W9dbPJ9monBimcXvQvLhUSG9JQCDgXVs\\\\\\\\\\\\\\\/qtr\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/acdr8SjNtuixRJfh7wFTi\\\\\\\\\\\\\\\/TuzRiA3fY2vhOALTnlsh1yoww34gimZB7NKETdyXhUpywCUum4emCAO\\\\\\\\\\\\\\\/NDQxMhJU9XEkcPtAscROlbp5\\\\\\\\\\\\\\\/59SsBMsLNa954OmjimtYbmu\\\\\\\\\\\\\\\/PzeFxHSaTMKz9aWh2SS0kW0G7q\\\\\\\\\\\\\\\/2C\\\\\\\\\\\\\\\/YoLlhxDitGGNxsKhd7ZysD8eqizXgJ59jimAKq29Ukoc6RMO\\\\\\\\\\\\\\\/i5FX\\\\\\\\\\\\\\\/Kg4wt9L6GhGj5dKJTsuQPEPLWt3kWUR4v3a1X0UFzre2MJOVG0ISIvvkSCtm6iy0AppW8B\\\\\\\\\\\\\\\/vi9OBHh9XjFrh3o0mwwAiO9VVSNQ4z1Lr+gS5KFwZJMi6TWA9yYJ6\\\\\\\\\\\\\\\/JGso+c67GoJzRP6PsALyRqcl0GJCTJRTflY\\\\\\\\\\\\\\\/2sJUfRZu33cE5bMYZCrZ+1PvbUyAYvLRiq1utpIKVb0zeMuZlIK2fm2TjgfMplQcDuGJkPSbp84J8QD8Gq0n\\\\\\\\\\\\\\\/WoWfTxwWlWvHKexWSwrz2dT6IMTqMWNbDBRyrSV78Guv51yvSSDyuE5cgZ8w4zxrqOmeudrKSkBNO7cNlvPFpaeaylkwDiu9Em9zLzF93oH8tn8JhOn69c1lZC8Rgb213pm0pALSTfDzr62jPOYsiGYDe9te8PwI1kWJlTEOlUBRrzITjlf\\\\\\\\\\\\\\\/Tz1ru\\\\\\\\\\\\\\\/5ApWRYWz7BJvnAAegtl5lrpPCIgZ\\\\\\\\\\\\\\\/BP\\\\\\\\\\\\\\\/LGeHbv7vIAAyf++1qSOAwDKFK3krzYtHgjWtDztmzFS5U8uE+eNLyd5\\\\\\\\\\\\\\\/TL8IeepFnLVhiRli7gQZJcXG5NNUiLc6nXAhEC0CHWCQD4So3DLevHOeoHm2Qk7lGQ7ePEtuprJP\\\\\\\\\\\\\\\/r8Z8a2JOl83Xj66rokwB3RddbG6RwCpi8gGciZ9VkvVuMf0KaxL\\\\\\\\\\\\\\\/qBbkbvHbdkn1uSBuaeqaVmBFYHeea+cNB+vh2a870OHUUW5vUxpyR71zee5oLDrS1rW6z7JRk7eNAENNol1eRHRk\\\\\\\\\\\\\\\/Z0vW9u9eJ63+A+eIzAExFtjWAk75YAc7v+5tBR0Ktyebi69rtzSU1fHl3l1LDEagTnh78ETvU4dDVWrXD2zOiq0hUJZwiu\\\\\\\\\\\\\\\/aNoch8YWBpGdUPy43sC7LgoBq23o875S\\\\\\\\\\\\\\\/3IQVx2tX7065ORHbX8YzJkXI283WjNsHoeTzeCVExmDtepnSFWU6zEgWTenWXR7YFxw486i9fUqIA03N1\\\\\\\\\\\\\\\/BmNcpPdBcci2P78X2fgHsAhIkk1SL76jstOcr\\\\\\\\\\\\\\\/q9HDHzCAAvt4dCVD6V5MPP2fE60zJOU7RPyZAztMzJG6UL6Evqnpl6gxmJMpBgd5wfc6u3TAFhraGwYP05sD8DW7JrfSDQ6DsuBFw\\\\\\\\\\\\\\\/P6KAR4AewFyP9KGEu4+EKL2F6B75Ftj6aozPE2v05djRTqiT0r5Yuznb3EKnaOjPT+3DnjDjCuGhhngX\\\\\\\\\\\\\\\/+jztO\\\\\\\\\\\\\\\/z1o4LGRkmKPCUjI011rej2FCIp0NNOkj4dXfvrwB2rVXxwiMuXZq92Qd\\\\\\\\\\\\\\\/pw8PAeTbDw4SR3XsCYlYC4fqERA2K300f8169DL93o\\\\\\\\\\\\\\\/ENA06QWuHxoLfloGAo+JFPtGxui7eNtplC9INoF47KkOvpRvKKc6Stw8BZ6xvzkuaL30d+Es9akL5PpGAv2Bj39HrNIWqG+9elciZfvYhfoB3OZdFBP2cyLORcngEFA8LN\\\\\\\\\\\\\\\/ze0+mG53yjClPD6xi43guxk8RxchgdoAo9RqZ15wTNP7Wvu08Iz19T2NqPKSIjpqjk1Qn576+Xqb+0GIM6Yy09zwpdMOCqJSTEU89oz4hG5X6INweCbRmTrnWlmUBV5hP782Fyt30R2M4O7VSudislTSoSyVP75Yn4tz2JRGicdZ+8l7SIqM+d99zjXMMTshhTqQtWtzSJ6k+JWRdfs465SHyySISQ8dlTjfolNohJFd7EzdrIg1+6yNaI6YiWkzSZehM5OvT8nU7Hglu\\\\\\\\\\\\\\\/54mnMLGWhzEb5rYPfEVBq76mbFjzRiN\\\\\\\\\\\\\\\/r5AZxQmvrX5QEId3VEizYwjT49mX0o5wN278q7Toa+j\\\\\\\\\\\\\\\/rkcEYtAD5joVGjgX+CfFzYXe8gseAjO9nrJv1tZtH4Xoy\\\\\\\\\\\\\\\/lPAk4\\\\\\\\\\\\\\\/IBsCI9ktyq0qCeRJE3XxdFK+07GvFCBNeGVYkY66UoepJALRTC1Jb2XwcCEVtJOAu2BOIpEAmejNd3nmOzWOgI9pYa2Wyl0Z6z3LdarO\\\\\\\\\\\\\\\/vYa\\\\\\\\\\\\\\\/rJ7TcygnOMwmvk1hv9ySFL+sdntylqiz5J6vz7noRKVth6eXdnw6zPA7nmyYJE6ERjt5jSjtcHZQiT4hSixALhVr3+0ekfGRZeJHevh9aD2AHOKrO7dCoQ2Us=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00223Dvqucw\\\\\\\\\\\\\\\/HyCWi49Rq\\\\\\\\\\\\\\\/Ch8Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002273c8ce854466ddf0326abc5de020a3011ec99ecac5bb27614895dcbd88a9e741\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002856.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002856.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002856\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002856\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002856\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}