{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022kdXkgB8zB6oa3irrfkrPn4OomMir3TxUTIc0xL4fCQJwN0MlELqpDw90e0UPoksAw\\\\\\\\\\\\\\\/iFkBDxrOpfc2HhUfMLwIJBYvizmS6dnS5CON9C137wRXpoddh5ZBW0jOWmjeZLPYkhScPBCwWawkGmUr1lfeeZI1rQkFrNkEaxCZlv6psLAMxZ8PARid5xn8FV5e0LY7uSESGq6JzPrzKAnsD7yqVuAswNR8rv1ysIK6zi6FtWEc87eZhCA53QWuMefL8fxufV48nzfLOhuO9X8PW6fshq+bV\\\\\\\\\\\\\\\/ZrUl8z5WRCUOl4XIN\\\\\\\\\\\\\\\/krVC5LV5wgYBippQgZJSDc9RaMnXWDsgfjflhqWeKkCqSkXBN5\\\\\\\\\\\\\\\/hYCTVWs00dH69sJ7zEKVUuU667gnx4rnk5phYuIphLDPrKg6t6HzWZbqWY3ghAXfOuUeO3SeFMRZYdFz1nAP4WUUwPMEVONVowqVJ3big8HHM5qod7d1YlfQCrao3WKHBcLQUzNDOBzQHdgdnG1rJwPXyxx\\\\\\\\\\\\\\\/vNU\\\\\\\\\\\\\\\/FFul1vx0tiQ2BZlod3SNP8SPP9Bmdlxp02h9iEVm80SI\\\\\\\\\\\\\\\/s3\\\\\\\\\\\\\\\/Qct1+M2jhZ5ltLBlSO1vF9pnyiGb7oljuCsAfk2uIWsuvzUrcwAuiWYNZEusSKPJCRBF\\\\\\\\\\\\\\\/rW56UhazhPGagnVpedaoL50y+ENF61HyVVYrloSuWinMTzzDzd+8K1nWJFmwlWKfOrvy6F1Fl2Xvf6q3PTB6tpbz7LQAbRkFWFX7g+SwFAlIQbVjZt\\\\\\\\\\\\\\\/xFyoYtOs84fgHgUP6mkEH5qssdST3ObkmZdX3C1cTBCqZKp4k7CYTJBuYW4nUY0PT104HR7HKXdcpGssIVjIi6PdCBfpD6ZGcEoEzsCeBREnQOqSoqmGphsqrx+sWmauxuEuFgCo39Zi0ov+Nv0c9ur\\\\\\\\\\\\\\\/7lvp\\\\\\\\\\\\\\\/doBPTRs\\\\\\\\\\\\\\\/XNDVmdTxJeS5OZNCl3271ByXbwBFYms07jlce8J98SVogwbkuPveE2ByB7oQM7BCLRbJIw5MWeXkZHbVYhdAoo4LZjvvz9C4qEizuNFMCFG\\\\\\\\\\\\\\\/LODdkPuDw31Cr9kHAeRPRVIyjSJbStxj3Ar6TifQkdzXadnzbYPGj8\\\\\\\\\\\\\\\/SOe+guRv35EpqSymEyDufwPszobjQaNKQa2iBzWyONezCgb8NYaYoZLN3xuz0Xd3QMSjcbMtqkd3hojk6qkqVs1BzsNvm\\\\\\\\\\\\\\\/GQ2Xcv4WGyWL7CvWWgIrslyFDaMNsrI7OgGGMBOnacXWbHQO64UldB2skI0e7L2IhulUSQvjvFIwnCIrzkdqVUZD5zrZIs07RuxFQ+qSHoZPQvWn\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/PaKg37U\\\\\\\\\\\\\\\/ZBCMo4XaGHMEBaE34oQp65wPp6p70GETSbrtQToLq1ZCWcJRiSWNG31oO4ByEB72mGLGoaGNIzRqiRzagJHSxaUShvhoLgdo0mZ1vZCipD6DNpvhTgl6k9\\\\\\\\\\\\\\\/TBKKti35Xp+8titRinJ+j0nQhcy91kMIoZEXrCC008IySz\\\\\\\\\\\\\\\/n+LzEXSLHb1uTY8r5t9SlV8lKCJzzqVlzUC+Igo9RzVYF2uG\\\\\\\\\\\\\\\/dr6b7bbDxKrvBw\\\\\\\\\\\\\\\/760o3xhPtMCwuPXR9tJaFk4UVwSk3n\\\\\\\\\\\\\\\/2VXrn7nClyKmK0Wl9+P+vgHEufcgTG8bnF1oEKv3CCw3jl2uuQT+CSx25OjMBhTrb0HxR87KuPkrZcxyGxQDLqulYeNxpQHiDeuZpoWWxxiUIDWkAOzFbkRzPfsw0MbOVlHF9sir3d3njlhERMkX2HwSHqS0vlrH+4SQpP8SVLcXpbgoXiNKvXCz9M6ad0UrjtfrCrc8ZBRPGPk4cDoeXGvS1N9X8T0U\\\\\\\\\\\\\\\/c0LbcAEjfdL3SZmOhsYlfDZkPY70tDvgMyMwBVTNhtmWLurBPoTNdqDa2ZSgEWGJDSPuFg4ovON6v+UOUsIdhhY8\\\\\\\\\\\\\\\/+EBMIhCzLyu9j6n+1AqkJBPKKMwOZ\\\\\\\\\\\\\\\/rN9RTr3Ks63ef6Yp9FzyxPnGNZj6rHeFTrcjrPpiGfB+NEGsDRL9K6Fi8ChoFK0iC\\\\\\\\\\\\\\\/Bn4VgJJlxbstz\\\\\\\\\\\\\\\/OzvUOsFaW6cLmddHEw9lVyw+IQKqBKckQTeAi2HOZwtC8m6XP3X3TdnrAKGRpHjpNYVrDKpfTMHtwVDazZT4hlu4K5xou5D6ijCqG42aarGQ\\\\\\\\\\\\\\\/IrSYgzGD0lR4AxtD5\\\\\\\\\\\\\\\/20HUWFZihkmOHxFSQKm2lm3QggvGXI47NwVN2tUcC4BKSMSvm65lfeqiUuphnJHn65ukeQpnBJoOIFa96SeN4JVxYQmC+xyyN3ImJui3h+JJ59niqhJ3CV7h7F1CSwJE+ieH1De9t8EcLpWJf3dbchsQrC7abQ25iSMQsQ84Lsu9XKKVV1Q5gPiai9l\\\\\\\\\\\\\\\/zJQ8gkdTLI9X7f973agJWOYEmrBgI2x\\\\\\\\\\\\\\\/W8PgFRbnnA1BBa4m6d5PXt7FSjItSJhk3Ho61kBx1UyFFQFVciFNo7OlxCNZvz6HhvrJKMlWlz18NG8r8ljKydg1FEmHhInDLRpKzbyTKADfaCLA8+zW1PgtLzzqtE8D3O8\\\\\\\\\\\\\\\/SLQb8ZB6itL99J3146lx\\\\\\\\\\\\\\\/bKgfjuifhWm5ZfPlqAcw\\\\\\\\\\\\\\\/6UC3SmNBdsobc6MSKXqGoZc2b\\\\\\\\\\\\\\\/XAYt6XRP8W\\\\\\\\\\\\\\\/5Fd2OfAOQ6SI+\\\\\\\\\\\\\\\/3MP5VJNtC\\\\\\\\\\\\\\\/KnLd3W6Trq8\\\\\\\\\\\\\\\/mbIAGFwOmllvwKB\\\\\\\\\\\\\\\/JNNnpnjgSfL44cFKYGs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022DlPpy9ryg\\\\\\\\\\\\\\\/KlaPzu7Kpj4g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222c263d41948158eb487b8e4d3a056f1b0f147ea1f32dfc7493ef793a49c31460\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002722.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002722.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002722\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002722\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002722\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}