{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022lPzRsXNd+sKNwXCSRVwRuwo7gsG4Pm40X5ArTfvA+xBq+fLPdfjqIV7P+pwI0taZWPqeFgqZBJNyEYHXmvpF+a+C\\\\\\\\\\\\\\\/1hyDXyeAwJDfPrsKtzTTO9cN+dXzjLP16LLMQy89jj+FWIC5+AWagU+pEeNUQtjz8ChsTBVZ+xDzWPmQyKVUhAzKuknhBDGIRKtfGRpcHWqXofY1cRoCvkxM+usIeio41xAzGldZWGHRLOEho3Yqy9YJ9wsRm6UEjGe6nRvVOvRxZPI1RevHU73PAcHZG6Jwof8xDjBnQaDR1vdPIP403wnHVhkUhe8qpWsZ5Y2PNhnmrfpWvSZI3MYnGi4NjRZzexODu+F\\\\\\\\\\\\\\\/DanncXt\\\\\\\\\\\\\\\/vkME4o43a3LAPMh5HEZ5goZLYxH6G0B49c8F5TRuy8ii3OTXMreJF+vUE7sgl7ZFPgSYKY0wI2KsbLSdFv3sTUhlMW5m8jsLWoTyXo+9O0N63bwTvSiwGtKv7ka1Bz83K41cmI7odD2bXEyp8JzeITtKb5INflo9XcUdvDSTQn89xnUpZbPTuvCqrlW6KQlgNJfCTlL+yAN91nyh+5zftScer\\\\\\\\\\\\\\\/aA5ghqjGc2OoM0IAUMxi0ZWmVgblHV13NpRdPae4ocjuksaiMUUSDOFV+13oHQ2iHlWpuFYC7oeQi42i06fsQZT\\\\\\\\\\\\\\\/Tk4XgTd5zHyWJwmna6Z1+20TwRmajrNpSIr0h1nTpLrNG6MAtqQti2hNx\\\\\\\\\\\\\\\/k+m4tiKqLT54qNOS1EGVMMRMQ9iJK7+t1kRRKCRvEhLasJ\\\\\\\\\\\\\\\/efHZhuUpczw6pbRqLmjRkYetjC2uBdLgQ+rbtIaFIpCBmiPP\\\\\\\\\\\\\\\/C30MH7G2YbzY2ZmjnOR1IY1P6d+rju3vuULEff8T0Chk9TKKk3ooxBUr8zTjF4thF0SaIWkTjJROpxjztIsgjjJnM4X+4ehy9DBiObjd2gbWBdAtcDA2g1sCU+JBolaUaugsYUTZCGRQDfG13uK5irrID99DdHoBqjz3qM+0DABUI1Gz7TJc7kR5sVhuznwTSviA6vwGb2hTJhN1sxY90EWDkzo9x5ETKyrdLvE8S+wwX\\\\\\\\\\\\\\\/Aj+WOUgUKM0XVowsgxr6jO6IHd2Mt+g7nhgUCeCSq7NdtSTNa3ixAKf9NlcTxz2PPojRF29QadkcPgAY0zTteEHkOYvMxYlS0iuGZS7wda\\\\\\\\\\\\\\\/SLOo\\\\\\\\\\\\\\\/jQhR+cFLrfUJR9z0U59cyqUg+OxrQALL8tQQ+DbymLkrSwq09JShJgqaLtq0sU9J\\\\\\\\\\\\\\\/ctF7XIlTpEJrR\\\\\\\\\\\\\\\/XgYY8vTb8m3QkTP85iydIfIngHyrrIle7byM6qvjoA9cNyaNe+K5mhZ\\\\\\\\\\\\\\\/37V8zkEqj+Vvo0ajuMod\\\\\\\\\\\\\\\/4d27dpef5BqejjvtiVB+OKpIzOZnANfzsd2QpRcl\\\\\\\\\\\\\\\/428x5tTFSB6huZrgzSP8Toy4DUH1RgeYwBxOfpxi9in9nFW6PJpW3DlP8h3VoN88Noy4i018pou5rqqdiqiQum12jcwkb+kPlVQOnjyR5l2FBmySnsC2Zyzy4PXgdXN76vFeELBQ7M8BBPj+MNNxCBwhc930RWzqzesDSp0vmcmqQxJrCRA8P\\\\\\\\\\\\\\\/fkIBGyDv3FxKZLamdT0vCD4OoDOvKSumggrT8FnPMwpRYg1I+IlfZte\\\\\\\\\\\\\\\/eTmyhivrHWoUXDR6FZ1qfqbUKSXycpVMth\\\\\\\\\\\\\\\/p77+fmJe5\\\\\\\\\\\\\\\/xB5YkZBxXbIXBGnUbSfy41Jm3gKA8\\\\\\\\\\\\\\\/ScNZpX3\\\\\\\\\\\\\\\/bUmZbhizKrggor4lpCKEOsVxSFuxU+ubT6dwl83ZDT5A\\\\\\\\\\\\\\\/OFE79LCEZ\\\\\\\\\\\\\\\/R6NB\\\\\\\\\\\\\\\/EqSYJZ74NBKizyTj8AySLlPDPTJKMbh89N1r+Ymvbw7+4kS+7w\\\\\\\\\\\\\\\/6MG3CAPa37mAyxJJdxEbE3M6iAOhLyqX+\\\\\\\\\\\\\\\/vX3CLQURvAV7LFkq5DP1KaTdBk1n9aZ4vMx5TgE3n98TwhEgpPVfJUHRl0MBYMegJ8zRrAgHHjAvtmSnKnSsbLF2VUc1wYyGAS86RXdBxLcI8zW2khWnOtIR02rDfyWSVPihq7KRDmwDH7KYlHIQoVGCEr7B2EenusNpl7zAb3cYBY4jrZpo4FBWNahNqMvX8sQAt2Ct4a4qREGSNbOe1xAGSDtD6NAzJwKl81PASsukV2PgNsnpcvAMZDAxQQJbF2eVthY6b+MZmKSizIb\\\\\\\\\\\\\\\/1qBNiz5T2Xs36Yv6wBGlWNnZ4eHQ01EQnKEz6wuPtQCgnTTaNg6Agrn4l5O2OopWggQACoAwSjUvxqN0shhzE3J6un9lOtlPrdnoaLlNBHfGjUJJxkr2m7IEpqnUxTGaFFV3MatOQRL2KsX6kwT\\\\\\\\\\\\\\\/sI7sN\\\\\\\\\\\\\\\/iftW5awENnQAAnutIfWwdjIn4PMoPK2jiz3x6iZgbt61fMa8SDX9Y8F1R4kn5wl4yLiJdJAHCLR8\\\\\\\\\\\\\\\/p6Z9ve7SE6K4Hbeu3YztVGnnW7fxX\\\\\\\\\\\\\\\/X9qTgFWjbrIh1fAnEvKFelxwSyEytFc+tf+bDspB4GHFxnHPHEk4kb+OmFj\\\\\\\\\\\\\\\/Gyx5loDzpQErxOMaAIa8DYLrWNi1n3xS\\\\\\\\\\\\\\\/cFLbMMsPn9UlCzWCIte9hMufOssWUHpnOfLevws6iByvQg2y3lBlYh9SqL0iFytr+f5KL2KbZ2bMnl9UYRlOUpf0jX+1ZmySan8UP4NEMaFRAqpjQLDH4rTwRn3UPP4CkAkOUBctI1o=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022lkE8OuTSWoNLFLcFkQZs\\\\\\\\\\\\\\\/A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223bf7011305b921f16b3e16610e14e09a17a302011845cc1b64e85f273fdd0d59\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002549.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002549.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002549\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002549\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002549\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}