{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022nOBypDdpohVztSs4SRroZ5o3bBIv5qMazswTlZnV+g70yudAjCwDGNn3SffksZJ2fG57MFDZCDnDjbr9arq4peukP3ljZl4NdgwPAscHYDlX4OxAV2P+3lL0M+KVahdaDH2l1VEvhjEoUmwwJQnDs0vjxh0pGS6js\\\\\\\\\\\\\\\/ys7rIJ\\\\\\\\\\\\\\\/s6VabvKXGwj736WuRd\\\\\\\\\\\\\\\/xq\\\\\\\\\\\\\\\/+tykBtUwkko8AJr2zzB7YSaYrHOoStmvcDMo+cLVqnF0EfTcHGKnpnVlSVoBiGvlTLOdSjzpngnx6AR5PxKFsliqcwsTMlAiCWaCaJ7tK5W+xDz3ThDLWDEGxAE2W0wYXa\\\\\\\\\\\\\\\/YoyIZ0mlghYnHjgiolNmmn+bWeLATxHbTohtwu2Ra7RYdss4j+xNj9ZqQF9YyPcMbJEhYHvYciLcNr55qwsokNgeZrSClcOXfGRmIFqgmyu5593CjDSSgCNvkUy6cYHeckDrfCn4i\\\\\\\\\\\\\\\/X\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/0d3r4H3kH4uC74qC0AkVk8I+FKpxL2Pi5b5dGeeyImx5fF9CJsGT0+sQo+WSlfnJEzpf5fiZPKKt5UGGSrhW3NAV1V5qHLVFuUj8S393qTtc0CYr0bx85JQptHZFgCuqqvApN77q9YnYIsvXtR06ZgL0GoH6FrGsktSxcW+6Z\\\\\\\\\\\\\\\/FoFNVCK9atnneSHXl5tuaOLTzYnuez+EDInuckukWV7KW95xFHZ0hEvsVQ+qmfDgvNk965daBYj+5VuJGuWAmtdkGNb2kifL8ULkCLaxodFHq0zPsk80PAHwoijVuvDQQQ\\\\\\\\\\\\\\\/U2Cmn\\\\\\\\\\\\\\\/gj9VIdzcHpbLkbxjEdHpssYi1\\\\\\\\\\\\\\\/ZmXiw\\\\\\\\\\\\\\\/lqNcQMKKGbK3qjkrdmWXc5J1NHb6GIfJyfqoOuK2kPZRdgN69\\\\\\\\\\\\\\\/LqeKQ6mkyGmaRA5vQCubnPwsw0qnOh8aV4YB43iGWS3HRBctzOkRK9RXo1u0jfsp5IUe6OcpmL5lND6h6MTSNGHZJk+gd2YwyB3t86256qza4CWeKZlmX3AL+OFo0Irli7V72wMF9VObE1Ng76bdDsBYFN3TZg4FQW6137pqAIfoubrsq7ZcfKpmjiFnBl3EibO6KuBctp1336oaHF3CeFy6J38H8+vt7S5f9EhJSGoB84roL3MKc8+6+IlQA0oNb5fHA5kYNDZ4R31FJLS5ePJoasJmbRRKKsv23iqGznTKCi0Teau0\\\\\\\\\\\\\\\/3gxr4EyouaEWlfONrovOAxE92KlzsOJrgyvyC8zDd1OMh+V7cY6cjnsvKaWx0+T8L6+PFySxJMquz4oWwt7MN0lEEGIrsojRq7fp0cH19YgCNWZfqL0QHsfjI+h6ba6\\\\\\\\\\\\\\\/8h8rJ1cXjBH5V6MVVvRB2QKrkn+IeT2K\\\\\\\\\\\\\\\/oTWBP49eCRmq3W7Znb4X1ilVTmag6VvlT6+HzYRVOng74I5QQIqME0FAfrnclEMPvQQ5GOhc0Ejuouo9O80UjtN7Eqtq7Sen+c3xllg05iMvBAkuJ8eoS6QC9F2mMYUxUrWaSM9qpTLJJYnOezPXNOdVWUqCs+myYLZLvrX+0ITRRwISNJahxhD\\\\\\\\\\\\\\\/ooyKomjZ+a6y6mJC23N3MZwh3RZ9dfWRt9WO2OwDfDB4vHagOdupdgnHKvEeq8Hu90GUi8d3vML0RGkGE\\\\\\\\\\\\\\\/ROsE7HE3zMJCsIswZ7ORBZA2tPZh8IrJgz43bgsCsMpTLVxP7FzuVlYIMtYLWwGjNtPWjOIGbzDPHDptHkmovY85T9mc9WBwUHgzIJ\\\\\\\\\\\\\\\/vmX5phT3yRqEK+5iNu0Sh0fz1EEirobXLnFMKSkX8FcmfL5OY7OZbobWXXc7aa1mt6+\\\\\\\\\\\\\\\/MO3gd09siBOuvmaeHegJf2SDj7xDV3Wg25lbJSGCc5sYqIlxYJYiOhAk8waNh+v9993Xdvec4TOfkBNo30\\\\\\\\\\\\\\\/bqPCiZUBHUO78B3ibikiWjUeMTFKwdIp7U2RFRi3pXsEET1CyLJIWyIJ4CJdj289h0txR4JgG83dJ9XcCYgqPZbhr8tv5RNtQrrTn2dudgaa0ciUfz\\\\\\\\\\\\\\\/uFVkWjXJO68sHOBbk9xQJvr+amVUWPsWuNU0b+\\\\\\\\\\\\\\\/lRUzNXSg2j+v2i6E96rHU0hG7PKGovXwukDFj+Fevwu5F9fLGLNr6Ta0+VE\\\\\\\\\\\\\\\/hNYchf\\\\\\\\\\\\\\\/5vUxyRwpmHb+FjBe3NfvfyKQJACMpxNuzE8VACiecPUHb1gnyOS\\\\\\\\\\\\\\\/C+8RpdpbyK40Yvjp734efJjXr3pufaBpqdv\\\\\\\\\\\\\\\/GVd6kpZMXL9\\\\\\\\\\\\\\\/wwm8oYbFMKszUSJ5C2FeerEhzv3K84NXC2mfkkCojzI07TFDStlY9e5m5l00Cq4xpOyaIx9sXPEHPxqhNeS219JjmIftqVeBqNiGzk0+Zr35iqNTK1pS9UDEFZXZgY+jYhlpjpwRxf7xamR3fxu5gljUnUe6ypr1ghRB1+XW+YeATwISkemByfHBfdGjZxaMwoblgbYdX\\\\\\\\\\\\\\\/VCzogl1O1EmPOHw6ZbH5NjdTjOJArU76TnYEIl+bATQn9RfEQpNANPdhdRzv8zgtC5Xxys\\\\\\\\\\\\\\\/zLbmVJt7VDK9SrCbHAGWM6+BbGGQ55tijrgj4PQEaNdBtgOiPn7AAxjWbmP2f3DnbCbua50AKB6S5tXZnY2+Isi88jzfz4GX\\\\\\\\\\\\\\\/jH\\\\\\\\\\\\\\\/K2Dbqb496oDrLvCPswXzHrueeFn\\\\\\\\\\\\\\\/oibwuAFVUs+tWj4uOVgJ8n41mka4+14kBYj3nhc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ewn4h\\\\\\\\\\\\\\\/xpZN6ZGNMoXaweIQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ce2b5e9f477a735d71d618d614add175872873fdaa8cf3cec49f6fd059bd4d5d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002349.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002349.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002349\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002349\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002349\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}