{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022T5t+N553HTS5gqzYA\\\\\\\\\\\\\\\/ScB0yJizDezZQ7B9Gxj8XO+sP12cspfOhyouJoZcDEwOuX82gBrVGeNJBRzS9\\\\\\\\\\\\\\\/at3udaSe+CXXBJaVi6lVFhoWcgUBn9Umxqie7o239q\\\\\\\\\\\\\\\/X5U1H5ZI8uzcUtniqVK\\\\\\\\\\\\\\\/zCrQ7Tiycacu+7Hh4JnDjTBQ1N1fVGLJyMTi\\\\\\\\\\\\\\\/B1oicbK5MG8uFOYzFQ\\\\\\\\\\\\\\\/CQkJgRnWGix3VzAsANnB89pUL6W7slkVFanXa5iRGMl1c38+y2xPtBSlW4VA8h2nFxDkr\\\\\\\\\\\\\\\/Dw+V8B+TM94dgOqPqiWFgTSFM8qWVqIzfjhHMH73lW5jePsVvFSTu\\\\\\\\\\\\\\\/FdShTStNWfg2hXGUAU3+EYS6SZGzVf+JrW+aqmtbXQZ78w7tFYZb9TbR7OI7j0lwrHvGc080PVQg6+Tf6HJ6W8TeyDsuNa1kunZNP2YeNNxF3AOsrNCc47HPYL\\\\\\\\\\\\\\\/mS9F7cOSsOn\\\\\\\\\\\\\\\/Jt16ROZEm8DTef43sEaMqxN7U\\\\\\\\\\\\\\\/YphPW8kBQFIw6FqcFKuiEmKeLNkAve1NQ6CqpcFPjzzDO+AvSpk0fafkmIDKcVgpuQ8Nhq1T6LYwFeu6UZNg+4\\\\\\\\\\\\\\\/uqYxYaLU+uvsxagNivuS3DMg\\\\\\\\\\\\\\\/XAWZkHLhUE+o6fqkEQetB1he2fJ+\\\\\\\\\\\\\\\/zkpgSz9WUmCg7yX67BMIQbpi0o5nGqrIZbjCCTrBcQDNH4GX5PAWcIzuAdNVqyfRRm33LvjwxqewbS8p+EjJQp8Z6vIl4\\\\\\\\\\\\\\\/1i1U5lw\\\\\\\\\\\\\\\/Wc4UTWh8xQS9UAO9cuxglOnFC4Gp2eF+wWUBWlw4LLt30o9Y57aof3PYA+lrFbj1EF7eZTRTz5HXvPvpUCF2TojFYik5EWEv5di\\\\\\\\\\\\\\\/pPFCjwJPu6XYOvn149uGBgFzfxMdyrqvmM+\\\\\\\\\\\\\\\/pT+2AMvLdIMPWM50Y6FJu1yLdlvjdvouwGpYuz+cVo0LAPvnd3r6mPqljwbVPGQkDx4jV68mvzOrJ4SdKUOiNFoyxZkg4dIhvmlaoimRnDpuFwqlDOrTKeMPEMzJguEeYvjj220sdWRQspJsbkNe2hmZflt8T6D3nBt9+FQx94yWy9eUc2Y1TxueflDPL+\\\\\\\\\\\\\\\/1O0fG9uUGGni6mDzUKdWJfHxuxjXbaGOPoGsIy69gDbOKi1H6AlheK\\\\\\\\\\\\\\\/OWzvK61rHRBC+VUI4xorkYyVbG31QHdGUs+O6u5JFlwLS5lGYeIoneijpyJCj9l1QvoHV9tsVPZwri5zhjFXTurt\\\\\\\\\\\\\\\/ZyFUY3tj0P0RkiKblHLGKFov0juy9dZDfBNMJ9wrHAoOy8J6QScxtYzYtUuIaJsHtRyiW2CUsKOw3tyXT9Z481eM2z9OXJ8vUcETiO27LVc0z5U+I7Nl2vtIY5+oz4Xrb\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/k7V\\\\\\\\\\\\\\\/LZLYLAPSmf\\\\\\\\\\\\\\\/zsFwY+5DcNZ6CVUvlEAdDoYrsbsVPPthCuyh7hf8ybrJ8OFrsbZ8kOOymDJf4K28abCq8ON+oLgI9wmDhtyBlQ7n+gwiIcPf3NoPUYNvja\\\\\\\\\\\\\\\/VvANnuejrMIFMLct6oJCecjdWgJfCLQRThq9cAG7gKlzWUB\\\\\\\\\\\\\\\/7rjucXc6SwjtsRj0LDMJIecKGbM0FMvTdYHJ+yVrvkj4KsegytTO2l\\\\\\\\\\\\\\\/aRiuXAz+be2nVtMgpWMPEu68X971FychNoWIwu64KI0FNpfLMwCHul8qZLRLuhAg3Cz2XHdqfpgFGFN42s5jBf7lls4zawpDatDbQSw7xVHa5aZdOBp5OCPmwEvEZ27xSmg+HgDKp+Z2EpxPQjCZ47SUGIw0b+kXrit\\\\\\\\\\\\\\\/Ia6rzthauXky\\\\\\\\\\\\\\\/keVZVqS\\\\\\\\\\\\\\\/NNp6z19oAuFOLKv2U9o5wt2RlW1tbcwSHlJEoI3oLoepI1yMF7H5tzkV3vmVMFM\\\\\\\\\\\\\\\/1ira1w9s5JEP3LEfzDyFOZTPAF537bHJD9zaazTxWenwkZTf8ZvUiyWWUMUcI7J7N0pWX8W3WodeZnnqP\\\\\\\\\\\\\\\/BvC2fn72TUKUz4aVwuldlURZ9K+Wan2DNkR2+oMIdE7Euys+HvwWzhbjlpJv7Vm\\\\\\\\\\\\\\\/FHrqUtapEArDw4HB+tyoU48QP2ew4yqUh0eD1m6Khq0ZbT9lO6QPZm8Jn0PPR6D3\\\\\\\\\\\\\\\/3JOkUOt4\\\\\\\\\\\\\\\/xT89PT+CAgJ8tBJ5jDTJG1JX7JnZxEO0obxeSijTjwAwE+07sdj3IuPU4d6wuhUS3HilfQ\\\\\\\\\\\\\\\/JDHZIVStpPXnmhri4dha2jFC58AkY30rs6peBbJ+bZTav92fVdNLa8BCxs5QpAPYEFAuyk1epJsQKtWN0ud8IPKD64+v00NIJwFpx13DmQUiLh46KUdBQic7MmtIHTIAuk77ZgM8F+zWpDPUfpsYkEeUK6Tc4pIirx\\\\\\\\\\\\\\\/DV8ZrGPH4OhII4l\\\\\\\\\\\\\\\/63E\\\\\\\\\\\\\\\/o3\\\\\\\\\\\\\\\/CzUYWb9Y2FqFx6Nuuu\\\\\\\\\\\\\\\/gTC4YlRYsW6f1LqY6a06bjzWhIQBPv31eczSz7kMUpUU+4yaK3depLLkHRxGYmr8qRnDHUkW1QMEf+YHDPo3YxkrZPY6hCvO5Ku6VDIbJAkA3ZEaJZrO4cZgFJqkHoNjlUkvZdZxx1hI\\\\\\\\\\\\\\\/22d5o2u6wpKaf4yS4HXPpbqfhJBDBIrgiA\\\\\\\\\\\\\\\/n9vY759d9GN8LFiSIW8ZWjC4fXq5WXJSVfw4D9WlE\\\\\\\\\\\\\\\/NwYa5jLn0b6s3i07BjdTVcX6H1EOQ71FDeoP9afp0\\\\\\\\\\\\\\\/kowiRG8peSF4WFlg+hWwTJ5J1Uw0M5IB2CWMkfwePBLY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022s\\\\\\\\\\\\\\\/wakCctuzd2ATHFsTecQA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022241a95c26b7752afb229b7d84560a1d4225fe361c95e4a71fff680aa9f551df1\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002273.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002273.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-002273\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-002273\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-002273\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}