{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022nWtDj4yWIkLcVcJReXibSejinlhJWYUA7\\\\\\\\\\\\\\\/Gkl2ykjVuJBuQGm5i8eaNsrhZP8EjrIwhYGTaSnc72XB\\\\\\\\\\\\\\\/TngyloEE4kKSxgUC4rta43AAfYrGjYw9iUGKVaQlsekNBoBILb1TO3xsDe4VQ1QN+dFyAOxub\\\\\\\\\\\\\\\/LalWqqw28JkhVsfLdSznzsjIiWpstloi0N23CcS6fGeT9HG+RU20xREi2XpFnarjXN17KeIZl3gLzOvEGyk4woLN\\\\\\\\\\\\\\\/qxP8J+CMtXcvvYRiNwQ0fxKsXd7OWTA1ElXvLsk+xNaeBDHcf3Pqp\\\\\\\\\\\\\\\/8k8KOkIDan\\\\\\\\\\\\\\\/OFRKYDwmzQgbRo5Yvu\\\\\\\\\\\\\\\/W665A8dJRlxETyMDSs+z0YIPTAZUlJPOXsyuHHMYSyXEf4k5PlQhQWUlKWb8bgt4IMUwQXgTsTpnmZ+I7kN73MKB2\\\\\\\\\\\\\\\/lzq5z45eKwyv1hGnxWkhJkY1DnRaYG0Q+6yt1YSFaZdCINHXN6v9a00jnjoTPbXzXyvuV0QxlJWenjkauW78xHeUrSPhrJhPNJAOsANXsTRYOqOG5hDPHwXp4PX7U77is9e40w79wBbheshGQ7PrdG2PPf245nwGtYlUbegGKj2iLrRRBqbJEYAmyfGXE1RTErncT+5c\\\\\\\\\\\\\\\/+EsYIUOvCSXWndW2vUmvAZmGiKNN3e00RkGHcgPqg3t4rqIOs6j63Opd3dtbm\\\\\\\\\\\\\\\/wUF4fllCkZZOYdKjsPTUUtQOYGpQA74GFtdSmqE3Os8pdPJwcnDUN1GDq3+DN2070Vb6NpS7t7IoKEn5Kw2AOJYUgsHCL88gPjuisDO3yOvIDBu+CMdiFpJK45AQwzDY7QiGNiL+T3msmvYJ5G7vH+8JPqIZuD82npF7MeCoQxAuojxe4346RxIJh8XftQqxD+lWS+CzXr5s5uPak7CD0WC4IaIARf5UztHI73ahN6R4GVHqpOz4NFfZcrGFgqJskBaxuKmoTykor1SqVH7j62rtlerxuKWiTia\\\\\\\\\\\\\\\/IuVss12\\\\\\\\\\\\\\\/bFnJCUDbMYQrufLqVwHWiIh\\\\\\\\\\\\\\\/qRYWfRzTVRwpFxxCzpi39fN6RvdKcw6WQRS6Ua6LOTPahhwZsWLGKRthNoCJn\\\\\\\\\\\\\\\/i9nP9fVOVVwEQNCKynOCEIFXaVBXGF+HSYH+gO8X+QqdXEcylqMx5UBWka75w6L1e2PDQ04Oq+ePtYSiG0gUaLOYAQZ8xHKoEQPVbAS1wrDk+EyQ\\\\\\\\\\\\\\\/cUsPxl9Oja6\\\\\\\\\\\\\\\/LfR4eRgqqd90QvTPqOUj0WAhxv94z43\\\\\\\\\\\\\\\/SIXaDol4FYblmjYr0XkbAwwLsqVVc4eGeFwBPp40ehClFE5M\\\\\\\\\\\\\\\/f8ynVxXEzduR604DEIq8x5Vj7Iwo14hPsfQnpSbR9tDXDca3sIwNf7cQ216bWYY\\\\\\\\\\\\\\\/ktEM0wMF14AMcdzVF+wAJM7ngnEc5ZaX1H3M2wlYuDupD3f0rjT5CoPIl3usmLY6mJWk7T+YpNWu4EG9wJ61kDhUr4H2wahOaErEf0nnt0+3Cieqvoofrx8zcAXkkd0abKY6QSlpJ1oQHu9Q3azjTHZaG4f1uiZ3h\\\\\\\\\\\\\\\/GZP9bCHJvCqrn9vdcVRSiWB\\\\\\\\\\\\\\\/pwZAgMqfycaarsf0\\\\\\\\\\\\\\\/jjiXB1qRRO0+6QjT6YINskIgav3vO07LEtNwTOkK8UatKkUtahzdSSAEIgnAokRJSCYCXY1+R5su00a7hF+K4QvUEeJ0d1XFoF5ACK4Sfl4NmiMXIdqxuJd\\\\\\\\\\\\\\\/kvBqRuMxlFqCjBYMN6I9M2EVye6g+3tpYJCuyl4KLtYoeYUm+iDGYWh7cM4HnYuK7CdAVJ3NNi4bRw5dw+S5nNHhYjisfNtfIUXtzUh372DQz1hY\\\\\\\\\\\\\\\/71tNpe4RXDLoWXP2WobUJJln1FVK0ju24sxysMlFObcS+71T2moASQTBnbSmKtr3W2TnGC\\\\\\\\\\\\\\\/yp5jiVxOla1LpoQOOt+jM0hQ2xYsNmr0j9wjifaBHKjZnG7KUaXsa2CPrpuZpIIa8o7jDpIrVJ0MXKzNJXsbp1i4ObhDSE0Z0iUxTvZQ5N5N9BuzMLdo8WakID7\\\\\\\\\\\\\\\/bEBb7MmZLh49kgGP1cAg3wc7OxpyyMSQiBv0bqzhhf3qGU41tZLHs6EX8heXr4OJXAUeqWrsgsmLXdydBMacm3PowawLDlv0izpLsS9DrLnT0ZPuM55dVJq84+Rt\\\\\\\\\\\\\\\/cskd48Rt37vMTdgeJtDSx8ssEwnX\\\\\\\\\\\\\\\/I6kyZlKvp3Cd9obhMgPBtSiuPzS9XZdx2VIg\\\\\\\\\\\\\\\/T8LCLtMiTuRx+rIqTJPddpxzzkUVW+iFvCPBADWd7PpS5iJlX9Lw5DBsiAhFDUPpg+ql8l24R4E1HmRnZjpajUVNEkWffrLQy0a+\\\\\\\\\\\\\\\/QlL1WlgTCK3GjKZug\\\\\\\\\\\\\\\/kNuajOFVhUjPtBDpjEMilG3HR+fgyI9qEMquD8Nnu6WNe0cT\\\\\\\\\\\\\\\/I82O\\\\\\\\\\\\\\\/ttKijwCotTVp2fqeIdQbZgFpMt+R7q\\\\\\\\\\\\\\\/M0RE9hLX6TduMLWuAHsK7CR14SLgramtj4WRE1D3cRKjSSCuYdGmRFy0UUdX7ErGqQAV2jADiuIfpZR4RaNwgbJsMWjOhrMdjCiGGEUBhohYMAy6oH02XSsyB6Py1bItNWamPwHXVlwBNja6n0tZy04aYpedNpX\\\\\\\\\\\\\\\/YUeAPAeKLb6XDmrbdVR2T3yBYAEpZfzssuL3509mLL6vSuPyYj1ybeAAknhGwORrJRN2tPbmnahUUdBvcM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022P6CahEwbWEcgQ4WQAATfZg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022084f5db928f64bd822dd118266df746b00d6b5bacc53ec611c95394f9bd4b0dc\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002616.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002616.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002616\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002616\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002616\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}