{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LxJS2uttar+rXjY71BfmJxXhPctkeYEVLfg9JPHayQoJAbL73\\\\\\\\\\\\\\\/aKBMvIdmN6Tp3zz3VYm5bx6voQNySyDxEbVWNQPFPZqB+hG\\\\\\\\\\\\\\\/tzGaP5b4pO5+VgWfQx2Zl8NxZ76J4RKkV\\\\\\\\\\\\\\\/4iJsSukKjmOtg9F72WyoQvTfLLO1RWLajs7qmN\\\\\\\\\\\\\\\/2\\\\\\\\\\\\\\\/We1yBaU267sgpaJ7zhKKa76K8e3lWbXNzV2qICapcA4WwRKKCY+gK\\\\\\\\\\\\\\\/WWY\\\\\\\\\\\\\\\/i03eeUkOuXjAQ2pPFfk9nmYdqh2f7+x93SWBjV\\\\\\\\\\\\\\\/iGzIcgzRSZ3+KZnFANrpkG64xo8enfitQ5u6HrxiNJjEklLripyc+729vmJmyaZ4\\\\\\\\\\\\\\\/YnbbgB9xjhKb6kWDGvZFLLTyjusCbZfvHRHMsQORfMQ+QdjchXT+MqKuiEvfaiIH6+enTfxXLYcrnmYJ9QFUPWK9H202K9rIaEk5IKrv3Q5KZbzXwP4AwMB\\\\\\\\\\\\\\\/fmcfoIj8hlRbN0xdv6n4h9BsqWRQi\\\\\\\\\\\\\\\/f\\\\\\\\\\\\\\\/DLrmqIubdkis+2bHeeJZOahWqsFSkAMvUGRVgiv4r9nKdAqzbPF9Y4PjWHHTzrNVuy4JRGn6Fj+206Um13L2oTIscZktpBcBUpsp7HmcTFlv9GYy0nXZ37KCqz60Q1hHEBaAMF6MtmMQXhbu3zbFA3mdKIDL7YJ5GPK26lX+AxNFmLDBM8tUY+IA2FEFQVFqk11AKhuB\\\\\\\\\\\\\\\/yCz0DBqsw6b0tujEDoWYgGgtBiP6wJalHyV\\\\\\\\\\\\\\\/2Kp0eeU29JzGPSQ2BjVKfvuhAVm7vcSmNp46U336cHvFAjg5fxl7MAnbImUTtEzMCgHPt4CEC19ts+yv7RDdRUaJJFkQr98v5o8Hh+RPLPqi\\\\\\\\\\\\\\\/Cc6w5Ag+vo\\\\\\\\\\\\\\\/oXAJDT1ba+xqmnidLo7Yvj5VCR7cUl9ti23EUCRY3Da3YbXWSnwBuxkWrZe8W9ngwCrpCBq7RgFpG+gBWtds8B0DxvLH8RbvRvkewpQp2pO9canIyqbPzRdciKRavgsESEVnSrL3AK6g14IT4ZrNOBXB8+5uRtvxqbk\\\\\\\\\\\\\\\/EDPz2Nb5\\\\\\\\\\\\\\\/qi8nUjyLGHbUoQM+sejqZrpo7fNphZm9Qarx3XlRWLaGjVX8PDNAJK8NaR4xgHxjnDZ8DFU3EruOdxnIT01BNUtLw+O8QSI\\\\\\\\\\\\\\\/grahXvx5DLeyRv\\\\\\\\\\\\\\\/K71hZg6VWc63L3odQX3hRMZjs2gwfdVEh82FodKqRDifdBAQOb56EX+A1bXaS8BUpPZikVSAlkfTLSo1uV0PedlY9\\\\\\\\\\\\\\\/EHOSJ0pyQgJKCaaTp+yiQKILpnuuKoM2FLRr6wOGh1pPJqX7bqcBE52EPR+RX0tNrl6nxXyoiq6qwcf\\\\\\\\\\\\\\\/MDhgeOZWWLG5Zypf2Bzjoflw6702Czp0rRVMY8podfan80VBC7HfMIFnpIoxQsuvZg1Vyx6Bj5zenqq3NNxYIo+e8JD46MqbHW4XPedHY7OjcoFk6V3bYNIRGJ+QMz72Vc7guC3FZc9mfvqR3xXpHt1W4TCNHEBheTiJ8Et5nVpCBtqVCKIoSAe6OHdVmQZIYPG7Hh9OhUabwUMMPWZNLDQrlL\\\\\\\\\\\\\\\/oHOLqQmto5w3ME42Ffy\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/3U3q9EJJFMvNMSr+yKcOyBUSD8J43GQhRks3Vr6Yx7bGNabsIKTWWpisHJ55XKR+qe80STq+laLx8o1yolzbkrzv2oZholbg4uSgujBqTYkGy5qP\\\\\\\\\\\\\\\/+9HejcSr8n\\\\\\\\\\\\\\\/7RpvYAvnHfhFRd9SMAtu1exkLZDJnX1aV\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/rBIxuyocCOtLO0mk1cHMhHimuetAKNaftiiOkgjrPTxdTi5heFvmUsGLAADjA4uKXjHyh4iei3KG4rGUkd6P8R3zMqLOAu9Ynm05nXngFL50kza0yQPje8abSnqttVwJ0cGcnIxgwcWfMSbeNcPoUKW6sULJimV9NnP0Rd9urKyAJLRmcn5t\\\\\\\\\\\\\\\/Fz6cfm\\\\\\\\\\\\\\\/H5c12vbOq95pbhcoM\\\\\\\\\\\\\\\/sPzfiGJeRgyoDzFEhxCMqiyvmdNRKT7fl+ycRJ5i9FJx4\\\\\\\\\\\\\\\/JyoUR7MVOUucpAS4nvA\\\\\\\\\\\\\\\/e0\\\\\\\\\\\\\\\/l6JF+PmwR1Pr0sTZUH1bMSxHwxeBsjnKWIeQZHv3oOtUdKV2RukWU\\\\\\\\\\\\\\\/mjxL23+AQQepmULMMwnMe888992p4GbtJE2kC7qqQrkSWmsS\\\\\\\\\\\\\\\/aUmrcKIs8pP\\\\\\\\\\\\\\\/yBvOCB682N6uo49vYwJVVjs56eRAizbK6YT1pqFqnriH5b7BeL30yd+JmiseBtKyQ1H7mHyWLBob\\\\\\\\\\\\\\\/rlxJeCoEzk5\\\\\\\\\\\\\\\/kINHHtDKBRMriW7YFhytkX9XCXmWG3b35J8qhoC4VoP3rsvpg\\\\\\\\\\\\\\\/16ZnBzyHFyjwBaiOoLwfFTkJpSi5hXJDiY3vP3BVvM1YumVYQo1OTK9xLhbOwgYz\\\\\\\\\\\\\\\/p0\\\\\\\\\\\\\\\/Nd+kij+vf8s4MTOgNrd2SWkRNtCHaYXDsZoE3CXkhBqjJeaiOLvYw2beauwYhvOHdnPDAuqOKAgnI55F5X0BIrilZW3XV4BEqOAo4eERayVcsXeICUTx+MiKLEtshN3xsGzm1XUwSJGHLwNsmHiLlp9jv9Wp2ykmJosChIg2sqJok0uxcGXGiQZebMUxGtav280pmdrhNFs+GGhGHB8EwJofDmcglbrMRPEaJulPUs4G7Gmmjqg48\\\\\\\\\\\\\\\/sA6yLK9yz1rlpxkGRiIjwDxhkYNaS6S60Rl0\\\\\\\\\\\\\\\/roskqVjEqEX0LXwiyV5KDgrSes=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022P09k2zXO\\\\\\\\\\\\\\\/7B\\\\\\\\\\\\\\\/xW3iF5S6Dw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c498acb1cadb9ea0a1617977ada39416aa726df3f727f83b7be29df5314f670a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002523.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002523.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002523\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002523\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002523\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}