{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Jtigh\\\\\\\\\\\\\\\/CohIPttIf7gvgfeuSRqvYWaiJ9W7EQnpPRFj0pm9+BLpHiFMLuXKsYZ83E51PTgj4dNXEkzKYxf5J8sSMcfMwCpF4+y4aTZ\\\\\\\\\\\\\\\/pdESvdKR6GoJps+\\\\\\\\\\\\\\\/4uQCBczsDwVkGIR+UFaYoESdPcE\\\\\\\\\\\\\\\/AHyd00k4DAUXYqu5APQjGOqX\\\\\\\\\\\\\\\/c6x\\\\\\\\\\\\\\\/adHC7byWNnl0HzulL6AEbcTEcWfbF2h6ZPAlBQua5Nx\\\\\\\\\\\\\\\/ewR5HHuaPAmMe3M\\\\\\\\\\\\\\\/Kr2YALXTcbuOWhwyF9pd85GghgX+3MDb9FI65rFf25911DKXYC02hCRyBE3+VtUtpMuj6Q04dVoe+dpRH0ZaBlC\\\\\\\\\\\\\\\/LHSJLCUo3b4sbiEXUz0rX9q3HVOsar2nKCWbIJxY2WfseppE+41HiBJORLsUbx0lh0mnqfQWM4yvfrjH2wMflclgAp+QLh5FXZE51pvKzyh8y5qsTCi726IznXNZVxuOboM8+GgjQVrCIyAK69T53KUL+vWY6uKqueQxP\\\\\\\\\\\\\\\/8ONTsb3dp+jmN95zWLVrxgteFVPZ5HyhiFNV6+l1zrBSJ742JS+pHHynmQJu4Vwk91M\\\\\\\\\\\\\\\/Knady\\\\\\\\\\\\\\\/OisnyOrtMbcwYeg6LflMS7z6\\\\\\\\\\\\\\\/NFygawZeo+GrSHamksdKt8mHlmEscQkHTqTU26U92j2EVJcUSnthbCW9AXOyroM5kMZ+QS9vcw1lFJ8JAirl8v6KWcrs2flKoorNqtG4fPxBsPbXFkSgwvsJ1DzWf8z0LYsDHOIM7r06NorbHCQBiyhWAmtgJyxPBKWS07wY\\\\\\\\\\\\\\\/4spTNnjKAVjOMgHmG0Khd2frvK72PDhSRd0WwTppTYk88ObAypqylN3BBuKGqg5Zj2EqHIxEKRh8UpEbDBSEiHz6j3JBEhFgtJhYFQ9BxWGlSJpFc0p\\\\\\\\\\\\\\\/a82fe2YBwivsb6eaSD\\\\\\\\\\\\\\\/FGe6iv0SPuZzyLQawkSLWIjkGj2fMcmHgHwPVZ9\\\\\\\\\\\\\\\/D0jtW1wSUFrQfSb\\\\\\\\\\\\\\\/rccrnhA4QBgIOBLxQQyn3CD1vKPwJMFamufipOUZzVyDjY4C0G4\\\\\\\\\\\\\\\/lnqPKnKgQTFdG3pxWMA0NTm8ymBJX8i+E+6sJcgYHSl6Di7sZtaoP3Kk+L4ENd3VJr0ilHNgIkgkL9OskG5ufQ28ll\\\\\\\\\\\\\\\/gLOZVkizD\\\\\\\\\\\\\\\/47Qlwz7P0PkrY76\\\\\\\\\\\\\\\/03+tktNNbWTgIries54MKHptmq5Vm5CXK+928PoQau2R7F5sYnnff4s4MoQdLPI5+tdpXQaQ5F\\\\\\\\\\\\\\\/pTO5sfvYvW9tnVKMyly4HS8IlH21XkOZHBWmDeBNlvmith7Qb\\\\\\\\\\\\\\\/qB3BSgeccY5Kg\\\\\\\\\\\\\\\/36jDOq9xQKwrbVzBZURGivAqQ52iFjRB+LITkrPwWzEbqQKGKzDs\\\\\\\\\\\\\\\/kkBdMoDQ8DrsfD0WLq\\\\\\\\\\\\\\\/+dO95dUSg4dzX6u2046UH\\\\\\\\\\\\\\\/83PjookIfMKGNbpbdB9V27ji8V5k0U\\\\\\\\\\\\\\\/OJbx+D8Un6K27J4a1uA3UduWt3iD8bU8d1aV26HYc\\\\\\\\\\\\\\\/q40HH2eJbRsuri9bRYz+nZEs3+WLxxyxSz7NboR1AwRV\\\\\\\\\\\\\\\/yqKTUNFpzT8DSbnKbgkwYSOPmeNrU90O7Q+BFI8DvWDmPUlaIthXoOl8wsBwITJbJ9XIN45vcmfwwG+zC2006E\\\\\\\\\\\\\\\/gypIqN6vyFVKof+mGH\\\\\\\\\\\\\\\/nLKS1cgjHDu0yW7NoU77xgAL7UWRGyMXLelLctOGCSNaLUuoNvbVqzR1nuwWqX7\\\\\\\\\\\\\\\/yAEuv2\\\\\\\\\\\\\\\/WhuNNPEegntfn2OeM7\\\\\\\\\\\\\\\/dZHQPKcmx2PlWFDYpTGeRprpwxfKIUH\\\\\\\\\\\\\\\/47zH6DnKBcVW6OusCj8uIlhahQiHOdjFc+24xG\\\\\\\\\\\\\\\/3+bL7HeYbdvv2e\\\\\\\\\\\\\\\/6CBUAGeAZY\\\\\\\\\\\\\\\/zyj3KexWf\\\\\\\\\\\\\\\/CbULh3SD6E9Ta9+0fq6LVyPggm018uK3oQ4rGI+sG5TkjJwvEDmg1oqMuNr4tP+vDhHDIaLknLL57vNzHDDZsOXab7rqUyLMSFf1k4s51B2LAlOTL41yQSCDZOztcbLUj2DQ0+uxjMEftKkzexKzwxGY+SyI7ugY9DFupit9GGL+xa0YOQO5qJCYxMMQR6uwLjCz90\\\\\\\\\\\\\\\/MuyQKJjzE5KoOhhzkniJSWikGzvUSrLXpXQ8SqGnr6wVGIaDPh\\\\\\\\\\\\\\\/twjshHsQ+MiQFIw\\\\\\\\\\\\\\\/tx8I7i\\\\\\\\\\\\\\\/uGLed4HLIV3\\\\\\\\\\\\\\\/eA9DqM3tFUjbY6Ays8fh5QZitt3cKUCL1pEe8Nso5X17W5tS+DdaG0YRrKs+BNmevWnBoJAm7jlfM0I8IiiEfjekRPzHAToo2ehl8QK2wgq6mqyHDXzRrmRK4PuyArkgN8fO2bKFVrSbPzhA8X1R8TVeOlEjSz4OarGCz1\\\\\\\\\\\\\\\/NFzu9PZ3GJsqmD646mTVy\\\\\\\\\\\\\\\/ErnxQEgpAa7L9Ja6EB9v9jllR957xUpxZhGHK+4OhZeLbPFu3xSUtOrUC0hrdh3db8WF89xdO9rWuoymLt9hbd3rAnhm4StEEIcpSvUuxC28uN66hrZ6DtP\\\\\\\\\\\\\\\/I1BJt7GpUO+aFRtHHnrKjri+p3pBeRaQPHv7ewtbnUHjHsrZhXsijR289PeykOr+mQAnIa5RDmB3eu5EKuUDK+dBwl32cLDD82UiIY0aXwgWq+gyPtlwxA1T4OTfsiSw05B98XpZnTjWZILEAmi1l7od3V8xlUwhMM5gLSvm6G\\\\\\\\\\\\\\\/LmgMgYNpRvdQl\\\\\\\\\\\\\\\/j37I0rj7p\\\\\\\\\\\\\\\/JfJP9BGEwEex4q3\\\\\\\\\\\\\\\/FYh+yKivKqFse2cdUtezth2qNls=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Em2lqvCsixyUhrmLZwmmoQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b03ad9feba102c9430149b29ddbf0eee1c2a7efce6a0be140a136d56cc6fa8eb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002568.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002568.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002568\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002568\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002568\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}