{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00220KmTC\\\\\\\\\\\\\\\/Nl2uJyTBtqhpUq8Zzd02kEx1WbeTMXoQd647Xkh117qwvE0RWL1AF\\\\\\\\\\\\\\\/p6i0NhYftKdcHEYbtrRds9eOsfMZrCqYZ4qjGhmSvoBVsOFSA7tdw7PC8NDLNkOIVrUZBEPzp4L7B+Ifg3BF6gGLjP4xii89XSpraJtpFIC2BLNjouu2Ee2mt2AVBxAN6fVbbmfxGyx\\\\\\\\\\\\\\\/tNG\\\\\\\\\\\\\\\/YzSRkQZD36NJRspdrZhV4D6fvMqKOGoX6jY9avKxiqipXT7YQ4gxuw9ZNh4SGup9wbO99G9xSYMN+f1DUok+IN9d4hY6IB0cbLlpKuzVaqZU3bOgA5Ul7ykzG4ZDe\\\\\\\\\\\\\\\/Gk4JbbJh+vH8OMkHqDXvo3RBxam9svYHEEEHUKHHoSORvd0f9GoYxkBdcgiY9WP8NGqDJPd2gcXz2c480\\\\\\\\\\\\\\\/I2Rm8j5LRdELL1jefJnj2DzoO+8aJlQOxAMeAXRMYDF905Cv+I+fH1skjd0ONRSJ4EvcHUY4a1\\\\\\\\\\\\\\\/wKGREjui+ZRCV2cTarMSBnj01qKwBTrdNYQa6QierMm+1L1ZYgjRV81wL\\\\\\\\\\\\\\\/IVaMh6VjInV9cVtcudXge4pckKX2t2nlpOJa6MwaliohP95Q49AUwGbC2l4NY9jYtoxZGrjmVgL\\\\\\\\\\\\\\\/81FaUMOgZijysy5oFLte0UdFKpqkWn3b8+kD6NlhRy0ySY9WkrunOTYepPeI7TL4ZNr\\\\\\\\\\\\\\\/EfF7FnGQRDDbrH3NpL0qk8X1Qd0mbH\\\\\\\\\\\\\\\/0FNA6ZX9sDawolgMZHfEqz9XeVuimZjnZPEjePmbtO1cT3t1xhapXs2pE3piZ0oUQbqa7qRkqoF87fxp7+caKoGmKMUDOypbEA4k4JLfqj9gXCGzWlH5BFZ+\\\\\\\\\\\\\\\/rii\\\\\\\\\\\\\\\/2hNBO4IqPbri5zSozVakkwue69ea2ZO\\\\\\\\\\\\\\\/iKrgFXtHotY2O3\\\\\\\\\\\\\\\/06zL6WPswexXZ4fvaahcOjd1IHMnbBSGvQ\\\\\\\\\\\\\\\/6kyYPtdQitsLNDOjKkj3kmzwhKxBMokuyKn1yCetdnfexx9ejUP2pMUfdehyu6T2jLO0iEZo0Rl5gIF\\\\\\\\\\\\\\\/gN5vLrFwgqR8ADidVM5GUXwZZHiXzN+MI9EqYTaCBha\\\\\\\\\\\\\\\/TURrqv0I+IgezbEDKvBTJkm7hHVKp1Gg75\\\\\\\\\\\\\\\/wZFtxCuTlyZ+31tm3lchKNpLVN81NaLumxyNyq9E82IPduB1aRfdRsZNIZnDBvqVPicX165WiyG3DNQrIB3uNzSLVf0PV\\\\\\\\\\\\\\\/k8YyhHQFPmBNUoQn9BsvrWGrhEQhRxoDHOSHBuoSA\\\\\\\\\\\\\\\/+gQjVd7SHfaTdQWufG1JYTkxPCZj45boV7krca930xP+tvruG0Y91\\\\\\\\\\\\\\\/SwOV5Og2PfjYDG\\\\\\\\\\\\\\\/+kqjvvA\\\\\\\\\\\\\\\/0QRiViXbKQudFtUj3wrlX8lK1eNxVFYOzrJHfCXeHmb3AY7DD4+59yHBqmIHoXBu8vo0t8lsU+UIPC50tEMPTSS8Qdm9FAcid4gf6CnDrDeOyEc3FjG8GL0r769PezmFXpS7BlU5XgC9RAco8m1UWtDuhLE\\\\\\\\\\\\\\\/ePeMlm7416mYLKhA1YaDEiE9425anX1iifpL37Ug5nyh9CF90qbsqdUJN4jregeK8JHkmHODsNtshIBzlVXIlZhpTaja9E0zmS8ZoXAsloDCOyg\\\\\\\\\\\\\\\/Rd36Gz5B8NFClEBygrq\\\\\\\\\\\\\\\/MUK6w8FKnnF4vYTckZDBrMrrVc7h9PEQBX5s6wz9KwueJG5FpHIA+Wjdd9+qqfWwLi+Xo1kFfrSfiEdcyxszpTe\\\\\\\\\\\\\\\/iziXUBw0WxpHwX+gscHTAh7x6gtjEST3S0Qgqh2ZX4B+VKvEoshRpWM6CJvYA4YqbLgIxEPzyooMxKBWMQvUPzz\\\\\\\\\\\\\\\/iSjzCzSo1w96HVGK6Sargrp\\\\\\\\\\\\\\\/nRhZc0qkdTEJ6K5QRFNvfsaBoXwcNXX5lL9PO5upDFkAUlsu6RHwPSu8E4AJaEI6SsabSPaiNCobQJJhV4zFYUvzcdztrLpS4pKtwIX5YtTbAdQB5lm40FzSI7\\\\\\\\\\\\\\\/uUeF7YrroA7uBkeIGA6ZRM6B2fL8iEh3JCeELGOfXibxjnNU8REcARoeF1QPnQg1dc5HeEFTIPjVF1hBK0setqksZ2cTdbZNoHj15ol983lEzkY9WRGVTdFzLlQqcCP7rYr\\\\\\\\\\\\\\\/lIIEG0HJ9iui6+W09a1m1JdT1qZkSbRKuzHxV2KdI\\\\\\\\\\\\\\\/GvD0Qm82qvN1cYijsoxhaUaJZNv0sZA7LHoshmdmLx5dcKjxMaxuZOWv7x21zh5wo4\\\\\\\\\\\\\\\/EVxHawWhzvxBi1pdhJdxgBIo9dBm0LFGn7pExuQbDrB7fbkXwSCT6L2ccxKW3PCITcctigNeMX\\\\\\\\\\\\\\\/Dk95XFvzXFohtJafQs+BC7zcXnsFSczQSAEqSHNxjmNRmRN\\\\\\\\\\\\\\\/DdgQDmDh6q5Y4PfP5a7hFGSe8nDrzhPdLr2To6suWumwAkik3qBu+5PCqppWX+iwOMcwJPyLJo0vm8b5OiN+BsoAGnWCH5pJYj064\\\\\\\\\\\\\\\/ZoJ3BrSeXeiPaD0NPE\\\\\\\\\\\\\\\/mvpYtmGO\\\\\\\\\\\\\\\/9nfsGHbJb9qKapoOFy1+rY\\\\\\\\\\\\\\\/dURbOfycLK1SPBgG0PUjjzHbtuQU12AQTkztCsFVbqxtzZu11mSJMFH8B118wl1+p4DzJFHXMqJRCYWUtMm0wHDjU6Uqby5KN0aQLS3KM\\\\\\\\\\\\\\\/xj\\\\\\\\\\\\\\\/KbOhGT5FrG8B8F7at25faPcRM9C5eMEQ2w2BkXviW5ShJOJNo1clU9klDVe9nk0BUao=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022MbRqgP0NEsXm1YKJVWfwHQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002210f0a997b0834208fd1161c4e85091f394397bdf8e50735e2abb2db29d02810f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/6\\\/e002029.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/6\\\/e002029.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;9\\\/6\\\/e002029\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-002029\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-002029\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-002029\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}