{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ukOMMCjrP1\\\\\\\\\\\\\\\/VaO3sdIz1H+VzI345EjLm0BmNuoWxXMUGL+zr8aVEg\\\\\\\\\\\\\\\/X3SJ7YQ4cfRh8AllV3RpVCU84M\\\\\\\\\\\\\\\/srPJrOY3MaYp283WHr9eOvbzku8r2tBhupU5e0setGP0hDbN0g9E1WilPaaPO7BpnrEu+GBYLQQHDqBoXT3O+tySjW9Da0J+3CNi5A4sYyC7Lhd5s9wjhSp28glt0zRny133L6TzyZojZrDhAqAMXwk4as\\\\\\\\\\\\\\\/QIH8dU7yLfSDZH\\\\\\\\\\\\\\\/vMSeOPEJqzgYr1gZMe+f72jlWNeiK7kMtzXOkTFsboEJqx1xQckhAnShWW4hXPB9ZpNlegfFI8ep15dlByJOomHWAk+UoP82tQR25No\\\\\\\\\\\\\\\/YaZStmiZ7CFIsn\\\\\\\\\\\\\\\/EV7hcyd\\\\\\\\\\\\\\\/fNC5W98dQ86AQfaVuSBh9nDmvmUuzA0gcKiJYFA9Rar+\\\\\\\\\\\\\\\/rO87x9kuWizjFqAqYBWaaYz7b84V62IqcUc7\\\\\\\\\\\\\\\/QaWa8E9DHL7To6Lr8lkH8zxbslwPsnUbpvE2L5m6V9nUy7k3FiEsY3mFnA3yDUgewv8zRedLKthuJTrCRLeKWZ\\\\\\\\\\\\\\\/nyIRk02YP47oonBHV\\\\\\\\\\\\\\\/gn0fz5chxgRwl7oYTSpwXEriuV5QQBZSLLGLJsyHXodoLBhzfsEWl0f8L+akB2WRz2nvxaROR4dB9Vfap8MMgCD2ZyRPVhVySpBJocRxhaWjX9u5a8M29yYwXm\\\\\\\\\\\\\\\/ltLX7bkW4pUZnVLJ04Whe6KSvwF3WqvIAQLYNmp0kpqmznMWjs+tq\\\\\\\\\\\\\\\/8kusxvp2MjnTDNCz2nWfQjWw\\\\\\\\\\\\\\\/l6q\\\\\\\\\\\\\\\/LrdS3++zw3myUXA5l+gg59kQF9m1JH1ig6F95wqpm2y7ayDC5qpa8fyu5oYkHPlWvjmRytuuNOo4UXs5aa2EoChyx2BnxCa5rfnFS2aTAcQORi25uTtk3ClZVYA\\\\\\\\\\\\\\\/+\\\\\\\\\\\\\\\/FUTgNmChCtRDVUpou6TDrsr4NM\\\\\\\\\\\\\\\/HBdSM6EsxQcR7E1q59GqmrGq5f4CJWgKClssFwttSxUMtE4CLTGn\\\\\\\\\\\\\\\/ufxoKYxaelcpTr3AWWgs9FdLAjxQcJwAA6cMAFZnvkWVUBIgs035MrIx158cSJfihzA2bcIBzfXcr9aBYXR+tg1aY7MPu+GBK55H8muaEgZHEYG9AH6xCdJOCvHnLX8ahyU9+F9eqvQRpXcqXEd7Otq6eUxrVhDfGSb2GKoXugG7kkLKa13a+O+vazySN97N2wq9CkcJXJQe06G6TUeAeTGB+hDyX0P6QmIJ60FWGeXUrWdMol6pqm6WgXwLB3KLhzw2gMSumPYwY0OV5kSY\\\\\\\\\\\\\\\/sqWadyEpxgR4NaCvCTdetjcDqI7Ni18AcrpySi2lmQZrVEEJ6b5KvfY8ylIvBA3xgCJyk9fzjGmBZICBMEuQ35+49hYQqjaMwMQ4mVol7K3u6IUoywLYPqMPV7oN13uCrhX7cJlAD9jBerLnGwIvLxt0dnQ1FpCgiE2E2XX8bCcj8nh5XAfLJUXf7GQhVp+FYuecPW+cYjcebgoZqoOis0qFQ\\\\\\\\\\\\\\\/Gt52ggg7+RqSxs7u3+s72o3MCHebQN7c0uxvE6bszvv9uOF3gIzyjJPLCJ7SODgkN4igZMICcfWOEZwtrn\\\\\\\\\\\\\\\/ROP\\\\\\\\\\\\\\\/msamIilM2Ttfd58a8go1gk3Lwp4Sasu3f0VSRtAXZZuAMNqFbvZUBgqLyDiuvvg7YHxUYf6o++yCnTNJAdroC0hjyalfv4+ADbUFIvyBkDL3FDlIJZtqnm+Si+WKL20RwtRatwuLd4yiO6+xj8bbMG1TGzht0txJk08wPBj3SgApVMMjjNE1y2EwPxTheVpdZxAozEdf61DIS9GXa3p0EtExT42C+1DOMkK05YdiocnS10c6Nos\\\\\\\\\\\\\\\/UezaEb+JxxLVb1z7jE1nih+O2QHait9TVLnBJ6NCAeuNaZygUCA3KvSbvXAo8zrFBGPeUQOVjFpHZmt6A0\\\\\\\\\\\\\\\/1+HztpWZDWPvHn8BA8Ehd2k9lkNnCH06T94dePUAHH\\\\\\\\\\\\\\\/AhbJLdNu3ln1tgWsQV9DQdnrOdLsgwAOtIIprEiVq3DB8FtxjdX56sxhih0zdvAOAh1kNqimi139NTeXDKZZ4D3ZTTe9jbLLBR2GxDjeZC\\\\\\\\\\\\\\\/jpDlrjbfXe1AktOqqX3YlCvBWpwRDUyIfk7\\\\\\\\\\\\\\\/T7ZL8d6lEZ+YDAXmPZ0TY1DGQejAzDJqdeJbKvA5\\\\\\\\\\\\\\\/quwO2ogDKFB79NWTWoCxvr8YK5vhOCGp\\\\\\\\\\\\\\\/6aQQ8i7obJAxtY4UM6lr+DjR3Csrrgl\\\\\\\\\\\\\\\/smPxSfsPpAlFWy80LIZAxKmOy9OEAswGibb9XhxQQPN3bCLdi2EiRo5R9h\\\\\\\\\\\\\\\/8OI49wRozVlaAGNYo0YTT9zNuMgiiz92vOy9U+NEg0\\\\\\\\\\\\\\\/G35vuG6bWgMuEohhQOuKrJGhvhte8ZFFQQNrqaSFLFFlH\\\\\\\\\\\\\\\/MtzrgPj78duNdlCM89BF8VO7Js8AMTD5qttXG3H+4QjVTsj3DDrIIBBbn2q4sEs06tB0c3IE2gDgeWjhXY0isEHMjkXKiGDajUoWyULhMIHAhTvCjlTD6nItd1QWV7fKgOIqtHsz\\\\\\\\\\\\\\\/bGIoQ\\\\\\\\\\\\\\\/QbwH9Z7qz08jf7o4N\\\\\\\\\\\\\\\/tUMssvxyqu6uazRsEAUYL\\\\\\\\\\\\\\\/W7QPmTyqd+x4aqgQXNykSw4WGWAzfBTdIQsXGmmneiGmY7gfliVp+n3QxlJGGgC1pD7MVFUdw86MPXC95abHVWEOLTzOL0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022cLBfRRD6eE48zJFDxO7qgA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022330c3a450bfb4248cff7c29ead888aa60ca779ac44d905ae0b2f401e4d7f3437\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/5\\\/e002694.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/5\\\/e002694.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002694\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002694\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002694\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}