{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022glx4HMCJ8c3V3Typ3XmGTcjL\\\\\\\\\\\\\\\/p5Ci5iZlmb5S3N2MhrPEwCL\\\\\\\\\\\\\\\/f0IxOyDgo7tRIQwSBDtGSlzaJOQj\\\\\\\\\\\\\\\/OG3TSnO5\\\\\\\\\\\\\\\/VHuySZg\\\\\\\\\\\\\\\/orMuRzWtctGZEMF64m\\\\\\\\\\\\\\\/Fk0jn8A3RgkTV7oAerxwqjeApHi80ncbWgmkzalWlV66B7ITLQJ0E66dLElVTNtsvQNr2upahLX5yU5Weo2l1Bv6rLx8EBE4lMISCeIRb1KV41oN7418lmNowlFUp8TVJRjxj34LuxBV51oBQJ1AaEUd9DzIoQ1naCHuIK3UlW4m9gNeDe\\\\\\\\\\\\\\\/bFextdF4cgWPeEdUkMGs7vwjqiQP5+b+4akuj4t6HIdJc0mZgr7NdAQFaPN6u5Ez9wZxqr6CNDBfkOur8CrJ+fnAFyEjoK0mB\\\\\\\\\\\\\\\/fDR1ouIy\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ellPk9\\\\\\\\\\\\\\\/jpuzTrbtAujOr2HtNdmA9eIhkLBxO4yCWIYfYWsoVoihBNjhWpUJzKGRm03gNS9qB8ANAvvMmeFnruVgJVlOtte38eLLxJr6MsZ+P3pnN0g9zetPZACOwEBMmyjHYY+a7ieGR+lQMPvY17PNBWsQvzl92RZiUPG9z\\\\\\\\\\\\\\\/OxmzCXCBGeFSoVzBThTo+oinQWRK0lxYfwRLWBHSAO\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/rHrCKgzWuuua2zH4AOnOZKREc6rZrL9Klllb65ixW\\\\\\\\\\\\\\\/3n4TY2Cm2Y2av++HtLyTFcF7nGH4RcfwktTVWFsCDM2mVOap1IE3YmHMMZBpcf6q4zClTK0qe8r2qmzGPZEj\\\\\\\\\\\\\\\/xCapR8m6tjklDwAEgPdS3tXzpqrVmvDXLPyiRuFrVF8qu\\\\\\\\\\\\\\\/mBIUzrVEHEGT43bM2AWZAiGplZuYg4ZkXC\\\\\\\\\\\\\\\/svgW7FLKAaS4NatqGMaqzBmpY0zTJ06yf\\\\\\\\\\\\\\\/hbBj0YxYb0aLa2qBF63Ffwo0d932Vhom63HonTMQWvr0CVXTrQ2Ltv4BLS0ySDYTCXKAGYDDoEwxS41YXYy+1mm+fMnMEUzyZy33shOvT7kn+WWA924DRorOfKPMMfgJXr89Sx\\\\\\\\\\\\\\\/KtldJRWSdQg9TMh\\\\\\\\\\\\\\\/uaQnAKFnnwUGteTXsJ0T8UnFvcPtYm4mgm0Vv61B+kFLzUypwHfyfKjf69LUxsaDjAy73EQqi7j\\\\\\\\\\\\\\\/g40VaoHbEEsMg\\\\\\\\\\\\\\\/CGo32CYrgUjoUDtEwayIArBGsZMSS0qNY4iBkDxPKPtvWnUvgqAlsgjUx\\\\\\\\\\\\\\\/dPY5ANNBeQIEgofyuAEb46mR+RMMFsgoyhsnePrO3MYKc4o8lwNTfU2KLtkbHoAlxSkhx2RATmpFjuj1rahZ7KKVihrD02jZViMi96s2RI97ZZPoQ9UBQMecfbJ39W+ZSPrYFTEmM90bMb2JjcYyMMakpR2jyvAeVb7UwB4s7N4A2W+\\\\\\\\\\\\\\\/ApVOi2mTzfQ45HsS4\\\\\\\\\\\\\\\/bbeCwv347XYBnOIa1ei94paqNHdW5h3aQrXDOr5vAQBjGZHAKARt5gXzfouSW\\\\\\\\\\\\\\\/N62b6\\\\\\\\\\\\\\\/ylmNO1d0J2YT7GWj7kz2AUQOGiNTJ8qRjwT3unjW0TVAC2JMEVBqSCuScWvvwYdM+T6FcNHIprthLcp4dkAdZwbt3+c1ytTbwcHeVUuIsz017lxXw75V22LNnE8jPetwa8QKgv3z0rDrCLe2e4PBsmjgQkcZDUUBWKbgi4HIdEURkLtGoC2ipu3VIh1nNM7owOYBd3wEA8tdcY\\\\\\\\\\\\\\\/R\\\\\\\\\\\\\\\/lKZgTjKvBSkLYEzq1uXK1r6zbw5qDms+ZR4H8d4Cs0haXQ+SFOihykBlUClEzTUFMuRBfnsyuEvvMbGKqi1zoFZZ45bx4XvvXYrLco\\\\\\\\\\\\\\\/WqIbm1nFn6WuGESJbQg9zqKs0BMlPBS1PaciaGiAEp1F0lAmcdIHYTOQNd94KS4qvOpLWQONoXY73v1vtGBU6KA3lzupPt\\\\\\\\\\\\\\\/c\\\\\\\\\\\\\\\/+2Ytoeez4QY7+yHIUto21mcpKC2g96iW1aejri4N6CYV8H8+s1z3l3dzOiIccAGywqG3gFqrpkvBnN6GnAJszI3kofo5sK7Pxq4G+DGRdBXAmBbEVz6982S9npi\\\\\\\\\\\\\\\/3bQlXyZpwfu5t0T1eWoR4e3r8tDnXVY1dwkvy8ac9ZnJQ4hFyw1Kar+pwu2zXHav7cv4LlJ1rLPbTjC3Mdcs14rFIM6p8eE4YZI\\\\\\\\\\\\\\\/G9a0X0hSVpIu6ZtH3p21OEyW7\\\\\\\\\\\\\\\/D4aIm8J\\\\\\\\\\\\\\\/M79yCJqo0gdJ8cyGF28WY2WaEoIG7HEgBd\\\\\\\\\\\\\\\/B0zMhQpHMaqotxlyG33QMOj5OL6GOmwQQ3+KYvZqOIt6MPOXJAWWqR\\\\\\\\\\\\\\\/AtEfTnkVJkjx9UHW3DMFHw0cklbWwgPI5AJJJVgdr2BCcn023RolkYivHzvLtNQEYjkgJ5RQxx+vgjSnzrd\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/2uXOVxMMb90gcdcoNNIROFG6va\\\\\\\\\\\\\\\/1LbqXqfW7NGqnCoWuwV0J6u94VQGMqPI80fjZm8juMVH3Kjw\\\\\\\\\\\\\\\/HM6PSvadD4sp8yw7N5euc6dpnPeOVZJ1ocqHTmosM2WgciEYIbk8T826mkqlh2WF8t9IEa6fMHMgbJBy9HbZmCn0JV5pUfb8HmyAb4iaCLQqIeCvp5TWA9K6au84bbEfqkRfELQgBzECKe\\\\\\\\\\\\\\\/CvOyG5F1BcEhBIDlzu5u\\\\\\\\\\\\\\\/xlh3dGgw0seKSL8IQ7Q95F56nKFfIzWFmlM2WwINV5kzobEDmXN3ThBFoqz2+6Q1tOiskIDAnHglXu\\\\\\\\\\\\\\\/aqDXpqxtA2XV\\\\\\\\\\\\\\\/mxfY+StpG4yU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022aQjp4q5SZDWoCySuGGYgsw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022401384d24fa469eee3021724f2fd1c8bb7ac7e0b81e2f4faa0f0bfeac46b6fa4\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/5\\\/e002555.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/5\\\/e002555.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002555\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002555\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002555\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}