{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022iiQP6QvoLJGbFwCb1Ywvaiwd7WowCNr+z4TwvIjNLIsIF6i0BzedPCUzoN7Uqw0hIrEAQoMkKvTMrjd8y+J2ZTwFyUXIuAihSzlfoDILFAHswKFbruyzWljrnWyuFFwtujWvF+brl24Tq1Czz5HM4AmJD6ZrwX1Eip6c9TMqDrTLIm6UC8ATlEfOOE2K+VjoFA\\\\\\\\\\\\\\\/xJKWhivxz3fy13NFfgkiMC2KGmoKPfvVQxMULyiYFwrxaCudgKJeNcBEz2AqcgbXAj0c2pvtoQZAQownm6lBpomH+5LNuvxnJGKTPfRIbwrmAANMS0Gw0C1rcc796jAqLp41TRfCE4FqHyM4jL60U\\\\\\\\\\\\\\\/1vOLtTxDEb7PnwX7GEZYqD9lLwJhU1SthrJY+vWyriNMuCxft\\\\\\\\\\\\\\\/qi6mnKQa4bqKb1PINMXbPdJ7h12TgxYaGTTi1ren\\\\\\\\\\\\\\\/NayvjCD5DZMi3g72bODaqFNN4A78pPkwnb6pnA0CTHeCQ\\\\\\\\\\\\\\\/5ekBT9aSeoMa0s7p6j+CQ014PpAFZ6iKjRC4VgPrYH11MEaVR6JrqGVINl4wCaIiVKxeCH5hJxziAIhhSimUqjsr7zupJnCqB5j0tc7ufujCI6RIFqdG1wEn+o5CuoSOHASyk\\\\\\\\\\\\\\\/bCTqB5sI8819wgzuvkBgHEj3bVieCjlfs\\\\\\\\\\\\\\\/VpQ0cpUoHXPy\\\\\\\\\\\\\\\/T7ciB30wKr3HWp9ZfBzn8\\\\\\\\\\\\\\\/LeVGnLwzcfBX35tTkihGsGvFtn7vj7\\\\\\\\\\\\\\\/Z4EZP+JS70stZzF9zBz9U6e9p1fLNHaBzevl+SlO1jxIaQ17E1tRUfyaBp4voOe63w64dajRQEKBLAhYtv17jgQzT7tz1z0YCbuGQH5gsv3cyattEH4oXiGwLeow7jTsnU0cFiqslPHQ2RX\\\\\\\\\\\\\\\/vQ7Wmy+rbwDlz6XHxTjxSNveRu8TLCIyU1GfxXCweeAeRz2pbahtX+V2g6+21eJ+sPS8pluR5WQPuIo0TfUQYqQu8bVNEH93Uk8bdzYHDLEYO1Qca1F3GwoGQAXgnBRL3Cl8rjM5EbefuY1G0xv7cZ81KIYt4h0NLBg4PPapiXCAhgmp6iKM5d7UFRq3GulUH5IyWuLy9Ui14M7tS0vb5ejQRGeejvfdv4BOwvwbCwHQqcbTTRqQmLfH\\\\\\\\\\\\\\\/H3fvguBA17tfn88l1bnfZQRBCOwZ6BRjrBvz8NLbipBk+B0vWeKaRCpLNHRRaFmJ2vRIqNYevdqwz91uEKbysadzRdk0gGYfS0UJC7QAPgoeVkOBNa\\\\\\\\\\\\\\\/LS2ySOBcea8l+Pc0Kc7e7vaeknuLvY5QVQtUA\\\\\\\\\\\\\\\/pk3l\\\\\\\\\\\\\\\/ddXePSHc2K88kQgbMxM2By\\\\\\\\\\\\\\\/PFo4VE8V9\\\\\\\\\\\\\\\/a9vTdahQOdMg941TZVp5Gs0xCxT+nzGgMrBNwWpS7xuieZOl\\\\\\\\\\\\\\\/FUBy26yV7951Ypuex23FqrMVvzfdLBjfGrfYLp6kkFLRX\\\\\\\\\\\\\\\/c2gp05dA47tjbCaxSiyA4P8bG4PzGmyzYWn7VCLbNXQTrf+3IF7KsAaw7z1neNzEnvghFQAGLCoV93zNinJyAwNoEXY+qCj56ULtdOX5Uwi0dDU86uFgqrdYxz86uzIbFm5f8A6P3sf83EzW6nr4JX8vXuGEoFhc9xzo\\\\\\\\\\\\\\\/P7WOEXEZRn09kx4jD95ta\\\\\\\\\\\\\\\/UzJIPgV9bOS68xDCEQ20\\\\\\\\\\\\\\\/pGl4eOlDjK5P9DGAphXSmcbgUChSxLB5wskg0nMGpUZxkCIlwEEI6kSv1UAdAP+CR51XmLgTTYwyMWvy7VkIflw9\\\\\\\\\\\\\\\/IjxDmf8sK39WsOw1GlL1Paay\\\\\\\\\\\\\\\/XlktUNFhjYwJQNEzcexlxGmhh9mR0+x89a7mc8SKZ\\\\\\\\\\\\\\\/aJg0nrRMdM17zcZ3M4mqN7c\\\\\\\\\\\\\\\/rHfq5+WMsMtBK2wVY2ltuGopI5Z3tOaA7k8FwEA7XC9kR7WHXVA7Pkkp9MMtlhuheXBV2QnFbJs9yGZ9Cn\\\\\\\\\\\\\\\/11y3fFbEYQ7Ri4nt3SaZRgv\\\\\\\\\\\\\\\/hMtuVS\\\\\\\\\\\\\\\/2ruloc\\\\\\\\\\\\\\\/1D24xwOMsUG3+5Kugb1uLgTLSIdCKdaPw1SaeXYRd8so0DJifyxlqKIaVF8CX8hlJ2a4tbWg0dl94ifX2zKGiCH4X7GryCuuyjtZbwPnGNgzlRZycFmU5ykNTL1iO8tqywHNlQBXBNT4kNthrXhWFU+PI0XW6rOs91wuUrvn58XgCcUt5dWAU37Sg0y6y0bP\\\\\\\\\\\\\\\/I0kRL3ewLXPNgZzvMmp7YluopwWbRNPE7v3M10pshaGinTMD2P1VUQ4stqq3MAjX+m4xLLwGI\\\\\\\\\\\\\\\/CbeFZVjJC84siw\\\\\\\\\\\\\\\/En9wxy84cn3Y0rB25C+IosGCTGKHe5Rc4GJRaw9Hc83NAgpCNsz\\\\\\\\\\\\\\\/2KXbq3Eh3JoSNogFU90\\\\\\\\\\\\\\\/Xt4WBZz4RTZhN7vxStgn4kcGHt0E84pLVFxxh0Ax0+A9889sxtTqUkAE4vbpV3\\\\\\\\\\\\\\\/3lUySTHfM8vM5CCrZrsU57T02U1LYDTNXrZh\\\\\\\\\\\\\\\/GQtCve1rMEeJmTcGXQiJxstW0lNa0pQUGNMELfqay+2xEId5SXqldjLzbbimJT21yn7R9pSe86PSSqCO4wMtUkY\\\\\\\\\\\\\\\/VautiWfkSPSndJqZo3l+hXVedbhoBemBDdTRipHW4ypuvzA6mV+yMMg0KORSLpsQUhx\\\\\\\\\\\\\\\/SdNCbgjy6EMuU14JruySbY46llyAQNgrJfc1wbeXKFeDksKEuGZ8P1frrsMRkzJ2Q5aGUxXRiqBy4HdwyyM\\\\\\\\\\\\\\\/hNex8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022iyH8DQeJ3rR+I8Ev3DcJCw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226dbce5500f164445e9566fa11724c5402153318767ded8ae20e1f8713634764c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/5\\\/e002493.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/5\\\/e002493.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002493\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002493\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002493\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}