{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022tmqsr0SlZbKCSVs0FKe1PqF2oRbK3uDOpQyjyZLStgHk\\\\\\\\\\\\\\\/gnrAPhDytTVYYzghnuEpFugD9FYUh6Z8cmE\\\\\\\\\\\\\\\/YWBSAD3HOo8KLCEu6KgyS7zE1eSt+qKHnXS+5FFXxJMeiFaPbYN1CJjC+JM42UXNP7C39sY9KsheZ4BSBnkDo+h8MBhLlEY+uKPrdt8VCUgWlJpr0xxUcW7MpDoe5SQQFCZJCC1pgwvtfxYvRQlaH2jAwCx3UbraoS0bmZzE0UuEAwtuemAvF\\\\\\\\\\\\\\\/fGaxnYGb\\\\\\\\\\\\\\\/cwSuQHmiqPLJd9ThcHuP+yc2Ts8M+2vUyVMMwJRFy22ezulqb8AfyR6UQM\\\\\\\\\\\\\\\/mt+C1UyROK\\\\\\\\\\\\\\\/PVr5I0u+Hfzz+ONqetGjBMcHHSGNL+rB0krfIdnchFCZkFLWnJ0BaavUFwkR\\\\\\\\\\\\\\\/O+ee4wjo6FYS0F0QUI\\\\\\\\\\\\\\\/qGv7Y7Q57Z3p96YBu2WcjQmHuscwzZupwanUwnbf+by7mangMnK\\\\\\\\\\\\\\\/T7zELcjPBd9Y8zLEeljD01SZWjdgyFXvljXSukiXda3oSBToICNaQ8od0ZyxIrouGic3diwwjDa9cQVbHGoLeQQXWbuuiwMUgU6rLsHLo8SMdXkMebfne\\\\\\\\\\\\\\\/9cp50JE\\\\\\\\\\\\\\\/srofPqpoE4QfV7L6vARjMOuMBIjglK\\\\\\\\\\\\\\\/YGs6v7x6DiQZXhRf+Ju\\\\\\\\\\\\\\\/heH4o6gZMRlbi1If+CLG3u7Z\\\\\\\\\\\\\\\/CLC2vRGUHH8+pp7aIAfg1e1j5v55Vw0Y4+qVcdYlu5vnuJYlRKtULkduUut3z\\\\\\\\\\\\\\\/+zZvItbO2A\\\\\\\\\\\\\\\/0h2z48by0rrzJhQmDa4ycM4NdybejAbA8RWkPgyC9P0mhAp9UariheNlmWXGOYK8eAp3PL\\\\\\\\\\\\\\\/qOuX2tjyApdzaqppwY5aDgt3wRNd15Qj0TV6ZJFa8ov+saQi0j+Azm\\\\\\\\\\\\\\\/By8snBx\\\\\\\\\\\\\\\/b3WdEqLad5qWmm0snu2wbI4fbHJMC2FlFwlkhzJXs3PZwlA5TkwkED4nG\\\\\\\\\\\\\\\/IEpVQtk1Sc6u3NnDR\\\\\\\\\\\\\\\/+77RmjFrCINCFOAprmZ25ALyAKIbbAMP1fxbPeWBEx1PVs7DcdT6b9v8gWTJ9OYoJxyXWEcFroy3OD4FRC4gZaBdFdQ7jjmJ5Nw9NcxYFD9SSKMSWnelv\\\\\\\\\\\\\\\/akFvDhiVX6UA8k1713y\\\\\\\\\\\\\\\/DfkxhgPVnNeJCV0mlkkF2WQT8\\\\\\\\\\\\\\\/ywMfaNFh9prD7VnUyvYWTRyRCh8M9jMHch28EvZZNd6Jar09ZhjQ3794ALzuBFDThqCKdtgIQFnz6nrkPAIXO6\\\\\\\\\\\\\\\/Wm4kRDTHfgZhRpLrTU9nwRKLpkbyi7NM9l7teOqzRO9QM7aXogGDetf4A+gM4ArxAYbDy8UZiQVRIMNKa6T9VjvhzKNndoFTrwcX53R7J42tj01dk0L3Kijp\\\\\\\\\\\\\\\/J9bfREvxu4\\\\\\\\\\\\\\\/4RrEResysjWs4rqjIwJDJuPLHIljbbSosAmgGYISJV550TKx01n90JRZkFewOQF0rhDmr9MOG0jlAuzcJ718rloBXuaLOZCq8QHPhURrHFcpNok2zly1ou7SJMpqnXIhUDrbyRbZQJSSP0tG5at32S+DeHmwDnVhPi0r+e7SuTgnUCqXG\\\\\\\\\\\\\\\/3XO571V3hb5d0XzeO999Ftpyp+\\\\\\\\\\\\\\\/Y9sWCkNwcfJibw5cgZdSfSZupqfbRW+fA2oKWZEjcMYruTuGTg9Lud\\\\\\\\\\\\\\\/JLbqtKZqOzuZYMUjMzndJ6l\\\\\\\\\\\\\\\/8hgFSwApVcmLJTwoZthPu2zU7viBDBxGM687Wkti\\\\\\\\\\\\\\\/6kHPDU5+GU\\\\\\\\\\\\\\\/5lEwqwLIhcBTvcrY1bANZe6cewutnTQkc7t0K+pMCs8B6kJuXONA+BFP7gRvuOtryPhdasd4JObOdoTsOjdryBMEjUm8gWsydbN5EQ23GV+Grvhwq9KjSGrzlyb6+DLtjx86nl+xlOOmeWy9CZsSehVrUNaBYaDGQoPzbkciaqtAj8zzlYOCbZcvlaStXLgRUXPBN1\\\\\\\\\\\\\\\/4xb7qagoS8YpU8g12wtpYu9\\\\\\\\\\\\\\\/k0+I5XRYMPziteObmufh2lhPCjTLfIG8XydfVfFCG7o3G\\\\\\\\\\\\\\\/9aG8zNE9oek5PK0wQcBIdLVhd7A4l1CSWr4gKBJ49McFmeBkZqmJcIIanzzRTaGmC5V6cbHyRb9Z9RJ9EbLg\\\\\\\\\\\\\\\/ZaFgK3y0t2HW18qqXtiC1Slwuf\\\\\\\\\\\\\\\/0y6hJvz3KmZiYNW3QC2U35RBw5MqmKA3gVJS5\\\\\\\\\\\\\\\/VsrMOlDle5TBBkPbVyHPeLUS7WHR9HLDZnFUvJRz0lcfaIZ4g2JO7ZDTqcfrK5zUNg+oPzqh6jQOIUxj1Yqc7bQHFCbT29Qa57C0OsJxSG0RU33iDN5tkrcl3SQ0Du32fp9y+4CRQXXhu5ZssQDlL7tvd30mqi0CiOVhfke3LZiaJZ7OOwebKGWT0FUBwTWjRFcfq3mMHdH0GsHnBKEZQjnSWbl7A5zoyHrbAXQsGPOTWPd3vPtFX5kY8EIZJktpdLZfEL56IbOdAwTWG2+LprIicaJ9diwixgJTxUAWc0ujJo+pQgVZd0C7Q6X2tuQA7appDlaEW3fvKTjN+z9ePY6xzr+hUbdnzl+CRbSrU4FbnS3z6JD0nLg9E\\\\\\\\\\\\\\\/G5umiiTQP2yR4qZJm0pMaS3K2xTWOsS2YsIto4W2aXQP3bmQ5451\\\\\\\\\\\\\\\/R68k1L7A21AWunfdDt911q6\\\\\\\\\\\\\\\/AKexQpnNcT1L4wTJ8zLKLMb8SbIRfaMce0xWvD9FvFGEinU764c=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022pkiIYp7I2abTfR+jtE8h+Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228f2dc3a595b72857551a680d2411b3edb5aa036343357c54cee4e8489b09fca5\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/5\\\/e002328.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/5\\\/e002328.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-002328\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-002328\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-002328\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}