{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022o4OEfP0\\\\\\\\\\\\\\\/RGIDVhcz4pBOJyyiSWZKr+YFLp92aWzahCcyGhdedKlaNVQrOGMGOSsU244L6NMfHW61DEO7rIhVwlw6uxIJFja3kYaD2CYQ1qqDMMhmy0hIe9xeiGKqRBwbyI+8FUCRdLUlI4nppi8GNA7Y390mPtOg9ZsyvjtdD40MKWhNeNSA8DHLUCU93qvrbZ9KVPBofGEnhI0K4g6KJ444u0uzvfCOr9YREHP+aMQ3h3HM+N9oozWgFcwT9M690eheEfymcrcnFQK9gL3AvfFtrC47aQ3jt1MjHV5kcuFbCoGBeE14YTyrIIyYoEbr7sRbYEQlwKJpFl9VlGznynUgoQDbsr\\\\\\\\\\\\\\\/jkCyz+SK15A46iWkXOWUBTYVwPyWUWbVYF9RtbyjJ18ednQoXEBjh1D0VCRGo3LyshKAa8rnI\\\\\\\\\\\\\\\/FEfB2OsGwAGy5ZGwedMTtsfcaYqm5BYnSyUM27OLwMGdpeG1\\\\\\\\\\\\\\\/o8wZ0ZPebriQfE1g0l\\\\\\\\\\\\\\\/DJ67\\\\\\\\\\\\\\\/PuyuWf2qyCHsgzDK29Ecw\\\\\\\\\\\\\\\/KD1vlVdlPaBdvxnKllbt+3vPGE8ioom\\\\\\\\\\\\\\\/fJM+4d\\\\\\\\\\\\\\\/Px45Bo0109m8FTAI7rkUM6FrkzK1OPR+05MIbqrggkkc69eWXrdMDVdRDb0QulHPN6msPgOtd5AXB3T1BQ16gVfdhYBQ8gaRL\\\\\\\\\\\\\\\/QKKnt48Ntxb0cC28Qs\\\\\\\\\\\\\\\/ROMYVY6n6Vv9QPk24OALWzBVWuBqBukgh8uOjyj42yiPqW2BEk8T\\\\\\\\\\\\\\\/kGnqB1ptEhHl5QwD6pHYygkXdZz\\\\\\\\\\\\\\\/ujEtbgpZqUg0q7qiuX7BUv86ABei4pGqjyStbDWzXTJjb+aNlRA15yLYkN86LiHDAqc5PJ6nTHjfbugETViFjN\\\\\\\\\\\\\\\/CEqR48OiaDWfC3FBfvcdBawKd7nnU10eSqqbvVOK4FOv4Bkhxh10\\\\\\\\\\\\\\\/bcvaOUViJJe+vNdf0QXpQW0x0nlWZ33XAOzQJzDLKHgw3MKvnyYphS2MgPDCYC\\\\\\\\\\\\\\\/KDCdZ0evGRGnGHFTvxdtWo4LnRveIrqn1jQmjJv4+uFmV0223YBIf1RmSGK5FiZCy5yHL0pYPD46jQdFqmODAP8VSSixWBqIhMvNY3L3kXuwF6iDa1fpv7S\\\\\\\\\\\\\\\/uLUfXbRgjUFMmN4B+F8HdJQFHCqDrHoxKbv9NAU\\\\\\\\\\\\\\\/suWXJpbTjFxSS\\\\\\\\\\\\\\\/R2BtSHo\\\\\\\\\\\\\\\/uznd2uEU1TKV+JqvYpech2f7oddoLl1RIeRN+ouKSQCWyP1n93UdwqJs10lKe1bBPchJLA9dhQFHFhiEeV8SlQxrxl5YpAzZYpyYK\\\\\\\\\\\\\\\/7sznXKuVGB+m+Zy6yHvRhV0KsC19Dy49wLn7Uaa35kBR6y8GCFdQuOWmf\\\\\\\\\\\\\\\/5VDlJNJIYvrtMDSxWE0rAMGX7Ibxt5FsjvyL7ufiwLDNehU6foieGvETl7ocYO4NBqOeLriBukOZYq4\\\\\\\\\\\\\\\/lGvD5flBihsFjCkXjaH\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/1\\\\\\\\\\\\\\\/CsMm5DPAD0bFXLTA91oN8UZmtfgVaXT8ubaUJ7gr6HmDnmZUdllyPO1+tRgF6ZTCTjpaVTXXbc7rLSkOsgTsrtj82vE7m672uuIP5c0XTRMy8l0JcDMKFDmC6FYdCFWma\\\\\\\\\\\\\\\/msYMyyk+M4AH0d5XoWdG47ajh865psuOA8qo69Vz1ghW8gJe462gF+h+RMGm9A1FhpzvQ53bHVUQ1f5SjkdSaS57X9KHwaj1ovWqL1VwBu45LaE1s\\\\\\\\\\\\\\\/IkXQDJ0mSeOByc+Yt3sMB+iwVisgVCUvwmRvYpBgzWxfT+IQT0AODfznf\\\\\\\\\\\\\\\/dC0hzn4BrRHJPACLVfLa1iDjuBSxX96VRCDktYsFS8Ab6zekQn2G3j3t3FBllth2U1rG0IDaNlk8pOc25soeOBTB7kuXcP59zJK6GjzVW3GcMMTaFGWHKjxLjP9KDJO\\\\\\\\\\\\\\\/mqKkDPo6c+qcFsEqYWqGzarZDftKdbcPr3x2+R4HdLmg+HEgTXQVUzHl2mWfBFunPvw\\\\\\\\\\\\\\\/szqKkSDXfkLAAO7ozuAMSLVwu7ZcW5l5xdOXQ8G149Yu3hjMqZKgyf5RGJZ3IKbk3pBOGsT0PZVsth2AqzEDH3+8KWyGU3+mOP4KC04NWmG8Uht8Vz3oK5NwRFCD7GqmvKprYpvljrEgNbvJ0y6rJ1\\\\\\\\\\\\\\\/Q5ecjH7UC\\\\\\\\\\\\\\\/Z\\\\\\\\\\\\\\\/jP8tIPUkR2MiVnhavfQldMTOZPk\\\\\\\\\\\\\\\/UyE51E8oCspUdV9+Ka8gAK3l+sNxFKtkTCXlPbKsIud6gsAlnv7ezIfiEMHjJZ2nWCLVXcbz+1U72fYOJSGWm1xNumMjmDp1L4b1luMckg3651dH\\\\\\\\\\\\\\\/LgLDvipzS2C1h2u14nDYkU+B0+D5GE86CRdcV8ie3izZ0fimf\\\\\\\\\\\\\\\/XA\\\\\\\\\\\\\\\/eDTBqGlxtAaoDG9l5VEPwmi6cRRV2ee9o+YNcAX9rBe+S100ONIFKFwUsabX5jPjLmStGcwwJEJLtWmlv0ZctaQJ2iEwzX4Cpm01IvOWoXDMHu6+dTCkFe7BHnFgQzhnHXgqfb0BeMk8Zkjri5J3Liivgr3FGArJGi0DUyPPIr+niEt0OilgdiruzkdebaniWydPjVomaLhlhlPVJUt+NkrkEx6hJffXOqb+2UKvrGAQfXfllbvH+xwt6NMhYsmSTN9tAq3heXbv9WHhehtFzhsHUde8HXRwhh7ZcPH4L5TM5xFojqS2Ddy2OxDTFmlP5X\\\\\\\\\\\\\\\/Cp0KUcCvJQArtScplhDY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022s8lwlJSyyOs0p6VmtDab9g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002239cef9428d2e0720be0b1bd0b7d21b2de798334b83edf7d5c5f6dfb97abbf9b0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/5\\\/e002372.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/5\\\/e002372.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002372\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002372\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002372\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}