{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022alo81b2ORfapMEmZIKd+Cp5jwls6IoKatVxBJQWDNhmJBr\\\\\\\\\\\\\\\/LjANLqPUl66RWS25hS6GDGHLJlapgI+YPZwkmf4lYwXhYX6i23Q1CJIxufL0q0XaojrxzR6\\\\\\\\\\\\\\\/6XtuYT2F4RIS8qvGFb5dXCizwyXCRhsXpL2+FznntO6\\\\\\\\\\\\\\\/rDTRFj0syWULc7ompLqm1k6RHxTc03+RKnQITdvclRUKw6TAQAZjIbE1q4WhDD02j\\\\\\\\\\\\\\\/LO0q5DmrDOC\\\\\\\\\\\\\\\/fWjMBIkS+tBlu6bkyeK57oNfjuKfmqOsRhQye3Lg7RpE1y2xLTObNH4ZAKo1\\\\\\\\\\\\\\\/dyywOQ0gQUwV9pqoYGLa3AMaxJ11wL1hNsu03WjTyYwGEWhYAyPJZlSvdGJWA2bucol7fqTKVx2l16+sF+XWhTPlwOY663bzx5KaJc0TcFDVpFc6NGfqwrJeMk2\\\\\\\\\\\\\\\/xIHdxUtOGZChFpQ6KwFoVuBRsSqqtfHaX8Q\\\\\\\\\\\\\\\/m+Lkriy98m1gH+7s4HSt+L6nO74XtQJZJViCMAaC6CtPwMWaXm\\\\\\\\\\\\\\\/QllOy7RHubdW8HG24fEnOGlUuoUUCmogmKkW\\\\\\\\\\\\\\\/vKLw2Skl\\\\\\\\\\\\\\\/1khuR4m6PgIIiA7hE34Z+ot1cnpROL\\\\\\\\\\\\\\\/V\\\\\\\\\\\\\\\/HUUw7hnG7kTNxIP8xAQE2WRcmBCVQrkOQdft3p7RL14tTQlbfFH7H\\\\\\\\\\\\\\\/4lGTThwBvFyCr5tP6NBczosJGVkGPvwM\\\\\\\\\\\\\\\/4jBjMaZTP8I7rXAjmO0JBvL56rGiT3fLYmE3A14cKMua07b7PefiYTo1et5z2s6\\\\\\\\\\\\\\\/ERD0ZVvjMk7+t2Q26NdxFFjCtiCgdaGOc5gAxOvpg36Bj0Yc7M+NpH2RGMUJ5qPgCLjpq4aogsWCftsLih5HjS5ZxgkW47ZlE13y1\\\\\\\\\\\\\\\/NmDPQ9s1yBJJCrTJB1otSKCeM8gdUUs+OP8MvJrHwY0rHwQayK0eVO3zNCmj3U4ETu3TTUHwYI29OS2fX2LO9LAU1KLurEyRxLGk9sOshjapYVo3RaL+uNMSiGfKmwthc\\\\\\\\\\\\\\\/vLTd648V8E8l3pVTdsO94hSwb+gHqCQfFk\\\\\\\\\\\\\\\/yr2exxeKxGzE\\\\\\\\\\\\\\\/0o\\\\\\\\\\\\\\\/acshpxE35nyQBeDQxOIf20zlCvToJCqeEEwKGwV6QzXrZyduMMIVYY\\\\\\\\\\\\\\\/sUODqyjfluAPDkm1xvCJc5qgSjNoQURSt03WquWcQYm6p8K3gcVHTtXty2rIPuSwaPzho9Sgu3j2uBW789o4RmD8KR6RZtS\\\\\\\\\\\\\\\/18zliK2mPCP\\\\\\\\\\\\\\\/wmDXvM68y6kTwcT2WiMLTexLIZmAGOs\\\\\\\\\\\\\\\/rQdaAvttMvczvkFn8mHNvyKEIAmNzW5NOGwqOj2gIR1pCEGHxCB0J3hFkTRBtn9u4b71ySW3wXnI9wLHPw4812IVC5dr2CLDh2Y3czPwHyVvWEYipyOoB1ewWzobz0TPYbmfJ6Fl1lnBQ7\\\\\\\\\\\\\\\/ZlgWGU7A0reI2NngY41HtzmAy950+TCnFPMerwtmRhJB56gV0J3YqYPiVUkffIreT6l49QbZWAev1KYDz3dZuwJHHKEK2fWc4lk\\\\\\\\\\\\\\\/r+vvjHw0aEq4JzhX6E\\\\\\\\\\\\\\\/53dUTZow3KKBFtt+Ytikct1ysrBiBKJqTi57k9qjHjvapUAWEte3XlzVRWJ7jjpY1uIQV76qTEW2MJzAEU4N6UB9u0o9TW\\\\\\\\\\\\\\\/a0HWbF48JaGMX6opN+\\\\\\\\\\\\\\\/hOrW47n4uf06y07h+L0NNVPZ9Gkl8bVUlqdLJgP8BYkknRQBmGsYDHeYMiQPJ5aErSj9N\\\\\\\\\\\\\\\/dSs5e56ompQXzwnlNF3yt8J45bk2JbGoGt4W66MyR5HKlLHs6FTUKl7myGWrIQY6bI5MJ+raKqGjk9AbQsLPxBdSMv++xwKI0OX50UE+uE9\\\\\\\\\\\\\\\/Rz8wx238Hp4OOj7HJth8W3z45KKB0omlMIcOykyxoYECM4bZ09v22\\\\\\\\\\\\\\\/a2j1rmngTk0Hvh7g+0zd8ZekZO1yivApXOhLMP8ScJZxlYm40XhPtHQXdas4uykv7s12H0VDMpCiI6XL6SgE2qRcdn5yMp7EkN9KaqgR7XyaA+UkeUCIOT5non+0NRZeUafEydCfCZ7zp69uW76u4DKsALIF+FtxXu9ZnnW\\\\\\\\\\\\\\\/oenQ7WzYwUjBETZ7Y5XZ4e5UPxLk\\\\\\\\\\\\\\\/29IoXpeIwxmTXloOMbQc5jPSAqvcks+6znGm+EzMefwWYWPjRGiixlWzcZ9W1iLqxBKECXlZt0TW57xRySbZJyw7bG85nljvkkwXuYLTxk3+sOjijwAMCBHAmMNbmqrM5i\\\\\\\\\\\\\\\/yw89je15YcVp0fzbhhYsvhQm1YABZiAwlMuCeIgM1D5isP1Y2pgYCya\\\\\\\\\\\\\\\/DekVgGdZudShRODH24GWQFmEpXmhsnZsziwh1FRDBxbVD5u0YaGKePg6zMvZPFSsJEOZw5c9hQTZ02IWwK5b6GcFV9cx5FyMJUPqFgYJZG8ijRbkeO6unkjBCrBLp\\\\\\\\\\\\\\\/AtOjAIy2VPneS2fIEzjxFZXTYx4wrNs3KOzUZ+D3AO+\\\\\\\\\\\\\\\/3mrThgtW9uyKKeZtizeJfCAw5yi6HUPUkdukuXy7msQw+WIjcsOCAvnwpiXGf92TB50HQGI9zwOtTwmVlaY41e5B+93ZTsfBXyueuPldVklzKn\\\\\\\\\\\\\\\/Oy3MK8wQ39F2rcd10RmALWZ0ZoMhL1FNUSE7M+h6pvBJtLU7YKrBXCWwEaKucdWfA7ef87JYJyYOrTWA3RAf6PLhizCdeC7tourSt1zi9Rky0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022k9sa0aVRiWHqHhGqy1es7Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228239104409bd58c612b278eccf029e46d18a2856e7663390451eb7855dad4b30\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/5\\\/e002535.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/5\\\/e002535.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002535\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002535\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002535\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}