{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00227L6mzqv0+V9vQrXnDeVJnz7AzLSmsSE7rrt4yatybrtgZsai1AbjX0SoIgFcjsn5cRVl8Tm7M7FTPD\\\\\\\\\\\\\\\/D3u8sQZwHuBNrbKwUlxBpfFjtvzTW3zOFwtTM\\\\\\\\\\\\\\\/4wbAOV2pixFrnC1ecipFXgEA92HanP\\\\\\\\\\\\\\\/nTs1A4y1eDylRbwH17ZYc2a9cneUJXeQOD+eb2Yc7bcQ5+Zjs1qODQ1yg5Zq1bZxkx+7c+hCxXRt42yCE6b+S3YPUo8v948tn5zzJTIyB5DNv0J6zK1QMpYcrQH0rAhqqTJclwxjXi3yvCUIGQSkWxX6VXDzTGrMQzCzOpPs16M\\\\\\\\\\\\\\\/KaRMJFPD4hrJ8CEsgaZXzY9KWk8P6MHR7Eq4tXx0CS1aSKTQjMFnaOTPoRQ26h+FgkbUfd16aAirguHhKabxsUmlyi2p\\\\\\\\\\\\\\\/k7Jrs7U2R2j+jGmxQUNFPmsV\\\\\\\\\\\\\\\/Kbo3IK9z6lZ1qbR8FgVC68Y19aJhAls8njJOhEOShd4WYk10KIaPClnuSE9HCSeIKQ8VKO2yOLXDsuvZhM1ofNsQO\\\\\\\\\\\\\\\/yHZJSkPu5d\\\\\\\\\\\\\\\/mk0d9rSFn+dKPEOF7TgZg0Ew\\\\\\\\\\\\\\\/PRHc8nO+Xyta7DjHGTV2\\\\\\\\\\\\\\\/QEmij\\\\\\\\\\\\\\\/jkDQVHnQm0ESw8HCG+hJsIPo5Ja\\\\\\\\\\\\\\\/oWUb0uGRgOTUZlzvyUiLniEJfajrDsvImGCoyi6w+NnLNPfaLt1qj5JBZM49IyTjxkbew7ibNXx\\\\\\\\\\\\\\\/L3xTZaeD\\\\\\\\\\\\\\\/fUn6FRCB03aIcdvE0dYnnhduQWimyRi3AFBdGVHzC3vfn9+IMT86tz3Jb3xAYGpMTcnLvScJNnnEnpyHgYcC4fxhUFx+UquqRmF9eX1xwjQGtMTCkB441ZrMbwMp8GcVifJIVS+KZTP+P54Ii\\\\\\\\\\\\\\\/SpcWrOSv9\\\\\\\\\\\\\\\/YbABHK\\\\\\\\\\\\\\\/YihbvZauizTFtv8ao8nnY4hTZraTroR\\\\\\\\\\\\\\\/uQssbqxaT86LYVldUeTTDBG0MJxJQ6kNCXXtUtgLPcBBGkrjMiKRTt51+aAAPPFB4w9OTn+mTdXf73Y14wa1bdUMXeeZzXhP6ssJ8FYFtQsJlMGAHV85iTTIg5c8VV0Cr9l9qfObPDxgrcBS8mZA\\\\\\\\\\\\\\\/u4u\\\\\\\\\\\\\\\/7yC91ry2Jyz\\\\\\\\\\\\\\\/y2+VdF0kBRKCCLQHAt+k7TkdNkoETAbqUWfYd1ZD+wM1I0lt5TXM25JXTZCdqIj86SpIRq4Z3AL6PQLspzugP3TzJ6GjQFYrdcXgS0Xv7tfI9KpaQK6wwOJN0EWt87o\\\\\\\\\\\\\\\/tiGMwDmpmEf\\\\\\\\\\\\\\\/bsIn49Zyb8Ft7CmE5WCQEZ2y\\\\\\\\\\\\\\\/00UjWicwYEC1W1f1S6e5NsAxcnkdpEfe1IUJZSoSOvRwvUi0u8lic1p9n7AeZVSP0UNsq08Smh1TyPDBeuq4ue9lbd6Svn6EQ2ngFtmidQfQ\\\\\\\\\\\\\\\/m4k76dabtIa76FcBlHBlooBcm9dogw6ihZItVCSYBDybSolhxou+KmwforLQxIVaHCTF9A\\\\\\\\\\\\\\\/0IyLsCoWlN9olOjVGEO921YHyqQ3fJnZltPWTzf+45MLObmk3vxLGnwFvn6Ryulj4oKEaEgUOhBoKHOELoBerRBCaJatc+\\\\\\\\\\\\\\\/i4\\\\\\\\\\\\\\\/WYLcSw7ERpKC2anWG6xV\\\\\\\\\\\\\\\/bPbv5ijRtzhHqnl3as6sxuSwwb7Aw8\\\\\\\\\\\\\\\/dvs7oe2HPP0BWLGLHOAhYCQgbGM5A8X6jANG+K2hUDPSJRa1W4vSM1XQXHgacZoOt0DK3crWZ3CernsBMpdWz\\\\\\\\\\\\\\\/TT8IxnfGBPO2L4U9rVPczZ+h9Ij\\\\\\\\\\\\\\\/76A87rEoTe+ugqTpbk8fgDSmp0E51eLZhYzLwHwe7Jui\\\\\\\\\\\\\\\/doYFTlxOzCZNoNgEw80QiLMVZPMvi6nyHAngC7ipg3S5OMp8ReDWqZZeRdGaqbEyvMiMDK+D7xCKYAq1FwRGZXkhJxnS\\\\\\\\\\\\\\\/sKnKNAhxNCTWulRG08A2CCLfsnRWu1OecGFLBnKBKUT\\\\\\\\\\\\\\\/0hA9viyBRuBjgMcxF1KAv\\\\\\\\\\\\\\\/uXs2cnXXWAiMIb\\\\\\\\\\\\\\\/c6Qc\\\\\\\\\\\\\\\/rYN7F6dRF65R0+gJ4fJPq6Jl8infqARYS4nEKi\\\\\\\\\\\\\\\/rw\\\\\\\\\\\\\\\/yEmUZDmu9FsDRm43W5l29G7COEJHUUEiH+mi7Z17t8xqVC5TOOhV8F0TTB+\\\\\\\\\\\\\\\/3pbmY6Vj\\\\\\\\\\\\\\\/+b6rap9dJqNX9OXUN3wZPjz6qewaM08Kq3Vlqdmez0poLfUr9EgkkxCaISqmKjz1rzKCxppNLv9NpSig+\\\\\\\\\\\\\\\/Omwy9i7B\\\\\\\\\\\\\\\/xyYh\\\\\\\\\\\\\\\/sKDu3vuSVn\\\\\\\\\\\\\\\/+jfMPhTT8FveO8ywHufKL6OI5ny3UHj4lX+esneTzf19Z3d7jrWm7IgnMOQ+Y2xke81yrX0JAtuDNzsNHM9aVJ69i+VoNQTeCnnSyNd9\\\\\\\\\\\\\\\/gIDJBZ5wZWCaG83GxhyZQikd6Tu4+rvSSEhrfHaEDnZIe3gYJvt\\\\\\\\\\\\\\\/A2Vp+EMRc05djpU+rIFlAzEbBFTVZ8VBVWJ27fF2+vg2XQEQOEEUj3ULjAeG3wr2JJ25Gl7HHWU3RRC\\\\\\\\\\\\\\\/d8mdzb38toPk\\\\\\\\\\\\\\\/kdaotBuUKGf3uxDnDffr3ll5Szy1Qtpsf6nxFOFW+Cc0un7WybY3ScNFQrytUT28KvWVCqZdtbl8y1C5iowLT0U9cj8T04SrhjD0uTqRomxbBRDUX0AupeuzIg7Ec\\\\\\\\\\\\\\\/5PI52ieWQPOtTSkBFrgg3PA\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/pVVu7AkuqanIsrN9qWfV0xsvZkhv4\\\\\\\\\\\\\\\/+lIbUwdTEFhi+L7sDHJn\\\\\\\\\\\\\\\/ZNp2Oi7NV+Xgl6iX8Kjs+hkxG+Xuu0allGkw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022klww6r+jI2Oh1\\\\\\\\\\\\\\\/Ecx42p8A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226647f59de9ce08bfd735a988592663bb38712810bf791a37c314a22d3ee0ae59\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/5\\\/e002232.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/5\\\/e002232.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-002232\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-002232\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-002232\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}