{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ZKRbzIu57Ox4VdJYQK2uQYo2eQVCoW5cvLTidfLD\\\\\\\\\\\\\\\/K70TIPOTe1rxi5GkC9iYtcXF38iczz+yqOU7ZAoK+Q08kPt0CmZqIo0NKsZP9Q\\\\\\\\\\\\\\\/ZQrxK0LcAYWcvcVDbTbGqXOX9Muaf7\\\\\\\\\\\\\\\/RorQTXzCqbJ2GtDX+1o3jJprzA6s2DOg8cHDC74pmCwUad8BvYoQB4yb5ZZd7Y1e62nSqp+HHfPOtzgB2dET9\\\\\\\\\\\\\\\/pld7a9GrvbGFFINI1i6Rii6O+0arYxir590jiZN\\\\\\\\\\\\\\\/olapDfAMC3OCuLEwNz\\\\\\\\\\\\\\\/x2sgHslf\\\\\\\\\\\\\\\/Bxqh3byiO7Ov7CWEjxH0BJZQaKiIByAXNKGlUuyaLUjWtWUEloa+o6Tjg9+c+pz0oTjg4f8b90QbMlSEGWrZv3WSZ+fu+sCshHemLcbjFqfseklqQJP2uTSdZX46YXdkC7hMFxI+oalXPrvlWnaYdVCtCGXAOoyJrvZk8SQu268zSkqk7uM8wdObZZqXeG29LUq3cTSFFblxfZNBhkqLD9\\\\\\\\\\\\\\\/Sx3wEFc9Aggz\\\\\\\\\\\\\\\/WUjMWC6yZOTfxdiYZZC06G0K+997LSObaOK53S53YHSxJDnb9M3YU4pqjbErA5HF6AZdcF+XfLLFOI3Em2PzSekb4bNWwxxXeTyjxJspOR\\\\\\\\\\\\\\\/ZkwwS5CheosOs4M9d4PdIDsTSoelpIkI6wXfGxceIEG+sXulGv\\\\\\\\\\\\\\\/llGC\\\\\\\\\\\\\\\/K0wFd+iiUFSsdXh8hDgbpxGn0us4mdqL6HpVI2TBhiAjLJ01ranZgwf23LhOD2k0TZ\\\\\\\\\\\\\\\/UhRaCU9kaznIhZcwHFoPCk981Lhrgwa0BkmaUMh4iuVrYl2EhuHAu22y+HHeWh7TQ0kt3eHkAhRtiEpwmcySfNTrflGYAecwj+ngdYEjY5EfNoTisdkgSUVGj8gHtI9P0WZMmYZ55NWH+D43OTQOkMS9eMsb9fzI6qePJK0vct+UsXhs0c3z1sNsXsz8A636IYeIndKdy0vTfcT9UMGBoE+TgTPuIVPeNJUypz3HB43zvoAvc\\\\\\\\\\\\\\\/5yLNPhEpfZbGSy6ZeTXhOEdwppoz3SS3GgVxR3d6aDYAb9vePO1VvA66CZ1YwUrVwt\\\\\\\\\\\\\\\/lZ3D95HlgZDyP\\\\\\\\\\\\\\\/AtXfavobjL7AqAP2Zx0IyKNtPTqMaSgPV3a8s7EOiP47Cmai+rndG4iqpc\\\\\\\\\\\\\\\/iNgdqguD6YfxtJdf6lsWw6SrH6+1ezRc8IVFbRY7R2rdGgKldQWGBpSG5SIgoT4e6SkQo\\\\\\\\\\\\\\\/pntexOKAQsONkeg9M9b4daEMAGggc\\\\\\\\\\\\\\\/oWl9cnyAtj0s9mUGUsiM87sT\\\\\\\\\\\\\\\/kDKTxA3lK1sqU4MXzFpzGeBUeMcOEYXpfzptJA0tKZTuAwruakZTKaapJK8Gx\\\\\\\\\\\\\\\/YFIV4y\\\\\\\\\\\\\\\/2qsueuj1C8KgrSzKndnRKU2YGvLmylgyVhbuCFoYoYMXMy83RyRzERRsDibK7aONK0c9JPUe5u+EIw7JIQLPv4OOkBcQCknc0PyBGBtEKjdaotLp\\\\\\\\\\\\\\\/RqPy5qxD2D6ybCZWpAdo\\\\\\\\\\\\\\\/tI9allY7i1WDj57q+r4ZrRKho0BLsXIj1luFEDhHPJGnRPzl9HrKqFR\\\\\\\\\\\\\\\/n2YKicGWRpBLlXK9BxfO21H58MVna+jFdEUetOKd8YPol4bhuU8egiOnBezT\\\\\\\\\\\\\\\/AMYL\\\\\\\\\\\\\\\/rPdJ9QLuBrafKSEUAhdKSmX+jvP\\\\\\\\\\\\\\\/qg25AQba0LGsK73w48M+xOYqK2hGqDdWbkN\\\\\\\\\\\\\\\/LuQoUDnh0wndQWvBPmXuFoqBxzY6+T9YHRkutMzSdwp90T2OqLsQYBbym1nfoecjxVoRm06Px3SAyPoY0DpbLGwt\\\\\\\\\\\\\\\/FdoslqDGApV2DIKnxHdE0i\\\\\\\\\\\\\\\/nhM1CW\\\\\\\\\\\\\\\/am3Qrmp7UIkVLwJubwxcX5xv8XeGigu9xLqjD86C+qOXNURiL7EL4d3EmOKj33qpM+pqo3O0mZq8UIbwYoOwYvMA3Y4VrBUmwWzfLn+1pADKj+5pR0GVZI7S5dn3bZrpFnisaQhteqJ+PK4eIZGy2OTQ5FD8IzGIU3X3w1PjMdpkyCvoJUOsuMP41x9gkefWch2x9lTq6oEUCyek8yzLegap4tCImIbfC0ZgXjONrJ7UAFdmlrpJGsE8kz1Y9JLkigPKcm+SsXtAPlBBYug0ux5ziQLJ\\\\\\\\\\\\\\\/azpY2cjwj5uxUSRBFw1ITikTcRbN9oouT+yyVf8ihPqdDo0tLjuMDi3ChYAPrELAL\\\\\\\\\\\\\\\/WX+uMFrfSk+m\\\\\\\\\\\\\\\/dpU4fhTvHjt8hSXNMpdLKRv\\\\\\\\\\\\\\\/PY4T05srWEDgmmWCOy8f4ZNne0Fw7lXLnEBJqeY+kD5woiaHQe9BEi5MPt+KJmLW3LcsHqSaPBvsZnPiAoOPfr516gaFYRzgdmn+DLTjzDvHqXrsUyhxDa8W1i6eRmz8MYoWNn7UUwbh7lFnYwBYDDhYPlcTptDn\\\\\\\\\\\\\\\/Ccd0vO5Vgbv9wnSkzGPf62i1aHuhzeYj2sZJ\\\\\\\\\\\\\\\/oV0I\\\\\\\\\\\\\\\/Gi1Cl7siB3CkWyn9T8z\\\\\\\\\\\\\\\/hoLora5cl8CDVlNT5SpNFLEAQiDDZ8kMGlXWrceqadrEesNmGMRzHR60Abmsulx1AoISZA3v5q3jM3dInOEYhyYrKIA2b6Bl996K\\\\\\\\\\\\\\\/fMfUooBX8B0VAOg7C7dq6r5lGSkd+dpzhWrg7FUN2oZiUHkJgXQ6\\\\\\\\\\\\\\\/wYPxOjX5FDNAJYgVD2uXD6oXKUuB5XRyXZcbVFhDSGirmtKiR\\\\\\\\\\\\\\\/hcLsr8wma6YWUakWMzqaQBf254=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00221FhHTUvNc6gLTJUsqg207Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c8fe61ab58c699ed89746ac20ec6e90c48fd768926da1f00942e0ed93f09eb98\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/4\\\/e001937.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/4\\\/e001937.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001937\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001937\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001937\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}