{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Rp8EF8fUNIk7lP9vIGk59x0zR6dEtzAnZkH6v9y92zqsGAXJ16iO6gRWwn+Lr828fTcxEHj\\\\\\\\\\\\\\\/fhMM4LxZGnPHh4st8zl4UsePhp7aZlnR71LIWGpZKzAqJVLrEi3DpM3wz12412803F3tP0N9zLuP\\\\\\\\\\\\\\\/4TG8j2jZ950ykPFMKuWe4+68RaDrd3nHbPVRv5fF9wmrI7F4rlPW0PUSu8gxC09AVWoVjk\\\\\\\\\\\\\\\/w9PJzwx2t0tdayWL6CkTOae9BxuCLvpnUJd1G+QzfGDGfCqqtyhzshLpxW6T1w9hOQCH66WeL1DzdNhrkpUF+d4FPfJPn+FrgJqT4yN7t7yFiu6LwIOkBts6a2zOLMVKQuc3fOJzfMSAY2wxY+ju\\\\\\\\\\\\\\\/eOqyaTv1VrxlSLuOXWOlYmOVx+41PFMU0bXYvs\\\\\\\\\\\\\\\/gutJTImcYtPSa9JHB4zero4QtGueMkAefayzbmSUNqRpRqhTX+JZeeUSn36k2lBcUJvxJBwR+5EQCYUUuwXxZjnBt4ih0wBINzY2MzvOfN1ThR0wk\\\\\\\\\\\\\\\/OcWlFPmGgfQXX7jKtF3q91sxmnlYiviMj7g6kJJPkPVF4b2cOpuOXhd136+U5cMJjekPZTna8UwM91oDBb2YFQbhc+xbsWkvUwqLwg82lm8tNcSr3hWbAV2kUMbBI0ZsC4S2m2+mMjdLbvmavqvNlM\\\\\\\\\\\\\\\/19TmZjn284PsUQccXaIfENbm510XLEei3l87khSDN8ZfwJkJSgvcxGSSaseswu2jtJG18zVD6LPjHf8GQD\\\\\\\\\\\\\\\/r3D8C7EZbME62WtaNpFqVDH1xjkSyINyYqXs\\\\\\\\\\\\\\\/q68sSA2Ilu7kRu2hwOwoMO5IE1fUeIA9uZmJ8udEywZwrpAoYZQVpqsqHQHwGz\\\\\\\\\\\\\\\/XydXG8B5O\\\\\\\\\\\\\\\/xxLXVHHmFDSpO2PSMBZNRapC+9VAzb7Wyp65aSPWRIzQIycdTSqy+s3IML4V92LPvtXGrXdGGMdwy2inAiznQ2rEx4FWsdKV7HA07nqQ8FrONGzaazp3S8ajBbJAQZu0JA\\\\\\\\\\\\\\\/Zw4jCF0M0f9Me9xJ9eW8voLAlX0IgkJ\\\\\\\\\\\\\\\/XLGwUdWp4KmpsV0icyGnZfvq27ykavw52q4T2tlSGQrxYNMskuKFkofiF1DW6lKac38o1l1\\\\\\\\\\\\\\\/4MkGEYrJomdjT9Oco8wHKbD947xVQ0nQ\\\\\\\\\\\\\\\/6VyTimVSm8QQ4cStgwZjo0y0wq5UO5QtAmw5zlhYpYRpIM2Bq41Z5RxaWfPGa1exDkLKoPdU2RYSyUxH6LWp64XiLBtpsna\\\\\\\\\\\\\\\/+1gK7cRPn7dGAeIaWbEKYNFlmNCr067reeHf6DEvV1g0TkYEMzgyP1rQeArIzYL8dFqGN38aoGDqA5wm\\\\\\\\\\\\\\\/9AMV76QrfBVDKqdLH0pAZxRC1bJhFwcKhtfjG2hqj+FKL7JTzJ3N38atXX3P3a9pYj7vM17fG5YJHWoT\\\\\\\\\\\\\\\/vjVceOMMV5R5vggILtJ7JS5FAju0V1lMNcKnGm1Dl\\\\\\\\\\\\\\\/Zv6d4epLj07IT83G3MJegziyEZdopiBAxzbwA6YpYvwWoh9HqGib81xa4VGAAJ5TU9E2Y4grBhE\\\\\\\\\\\\\\\/jDj+YLIY2RhHzw3nq4Ws0mC4uvoaSYN75flQe8ExS3qehoItX+u1egOPVoUtHHTsHqnh4UasNRnkth+vPLyKy34RdT5PDC1QmnpG4HorUNfmOwdojws6uVSOYjtzR8YwA7Zw7\\\\\\\\\\\\\\\/pXP2B\\\\\\\\\\\\\\\/zac15pzPL+RgNJPHsIjsKuEVJUg5GRlmQ717aTLC5o24KZKQxEkdKL8mE\\\\\\\\\\\\\\\/FJwoGWZ\\\\\\\\\\\\\\\/4\\\\\\\\\\\\\\\/060A2xaSDckLBn1SiFfAwEi5kWBCmZzNVjYfbyySbsb6ULr7vy\\\\\\\\\\\\\\\/vBtISkzIgMWzlvV3j1E1isGIJJcgeTolvT0GO77vqFI2g3IzcYkZBsHK5LF0EtZaQ\\\\\\\\\\\\\\\/Xi8r52jcLTDC3mEFr69gtk2zhSUP3RHjD0I1jtSBzM4IJnaQxTKa2HVLf3b1FyNyULeRaHAbiRlGznOaw8AiV8b1Ojn1RDKhXgqKqVD6T1mbpx15H2pPlKzq7grLDffR3DDO3lM4YjoGdB33QTQUIW\\\\\\\\\\\\\\\/Lx4cQfZPTl+ezxi3\\\\\\\\\\\\\\\/nu\\\\\\\\\\\\\\\/L7sHGNCXRXhBajBv05D0Nb\\\\\\\\\\\\\\\/s35LoOn0V6Qf+fYpkxfDfjTbqk+y6sOQYeS0yJbEG1DbdbYpriff1n\\\\\\\\\\\\\\\/X510RcPbnnDb4AbxaBu98MoykGicz\\\\\\\\\\\\\\\/9KY6TvvDOhchPoQRH4uLcIimk733dKXQ0Wep7xt4Ows1vdYPrzazxH\\\\\\\\\\\\\\\/vjJsM7CUpN4++pC\\\\\\\\\\\\\\\/lBm63912uR7x6o5MM3KZC\\\\\\\\\\\\\\\/lkzzJm6cOE0sIERx\\\\\\\\\\\\\\\/KZSQoufWEsxDbfc+ewQ8jX31bYPZuO4KdSxv7qJg7f\\\\\\\\\\\\\\\/uDNlVF0q6ffUH4+xnhZwJcEnTDgPPKeQoM0UC+4hcQcAN0b2sz\\\\\\\\\\\\\\\/DSedkoa8s7EYVSHxskEAsCyCyO4v3Yhp7zg0KYv56hJsHEM0yuWSd4ksvq1bGUZ9fowyDCi1pVHaICrJMJ5UBl50\\\\\\\\\\\\\\\/D\\\\\\\\\\\\\\\/mpMdiDs2I2GI6QMA8AfqGSF2wQnUXRWC9GyKf2e1yYZE\\\\\\\\\\\\\\\/mUCWXZOUxEmwYPVc4mOPPks1hHRofsCdKgksOrW+5BKu6kJN0GM0GeLkdwq0PKeleH4WE4+yYfgV9080b\\\\\\\\\\\\\\\/rSM79Rb7uhgzL56dvlRawPIxWFyKnnL\\\\\\\\\\\\\\\/8bIsPweB27SrCtjhz1Lz7IcNU2aTcxuNCKU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022lBU5Z1mnD0FYYEyI6afdqw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022111d2084b9ce273fbac9281453505251ca15a5f6549086c7a19a2ad178605978\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/3\\\/e001643corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/3\\\/e001643corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;9\\\/3\\\/e001643corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001643corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001643corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001643corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}