{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022CHsqOfdSqvDCXpvW82J89Fzonylaufz2hX4GkHK8eH5ne2WKpGtOFdRMbEZe0ZhR6MHIe0awBvxWHZiLzdJpjOdP2Uh9mznVhEBlui5lfjt0Tws\\\\\\\\\\\\\\\/pnG1EN0+np9+hgz4AwFwAHCLZWOW41NLPG78izTr+X0p+hz28p0GrRi0CZOUJ6SIJCLhvAGlIxD6XvgHlY0edA8UunE7xqnubyX913At9go\\\\\\\\\\\\\\\/r68jiMPBkI+MgkZP\\\\\\\\\\\\\\\/a+R6qrddQAhO5mpLUiWT+KG5Yu0Cx7JsQLQZtklUqrUbDvw06VpeDZ1gS841io3Fg68OfKuGNA9Jw3EM6QNi7nT+\\\\\\\\\\\\\\\/r7uNEJ5\\\\\\\\\\\\\\\/zSlMB8bRJ5cdcm+O7ku4YLVwO\\\\\\\\\\\\\\\/TXu5PhEWUmIQv2kJnV34dzxygB8ETbsF8QMzObgWuAfmpc2K2yr40j16G6p4gh37EvE3w3BRoOy7pRtcLhIbF2GPNlaFPc751TScvUsDP+QMGSdV47b6Ku827kDUweReU2yAcwhKA++q8KAncExFS\\\\\\\\\\\\\\\/9+03MQ1k0ORNK7NcF8Xx8wYLki8Oc2yYczU2Y+VFNbu24Sz4ys6fyCh67QmGv5YEwgZulcVgFxgxzxUghIIc\\\\\\\\\\\\\\\/7Jjm68j3BvpvVNIjq7UTdvVX7taf2wie7TA7THwD0R2lG+qkq99Kh5nH8d7Za6QvyP8MMCq7tjPp+u1fA4GVABaIDT9zXxxjnc+4ZlJzExVoJgAEPzs1poXhbPnKiIVKADqNQlT4xcriglHvD5sydq9QA5tfYCM3FDkncUmA91CFDBJDSnWQJu+qWDNc7ZYnWk8BMHZm3tDYatj5UXX8d6eD9uMyrYBu2vsCeAIKWJbn2VM72Rxuu2jRQcKhOnitReSG2TEzyG9rxIYobuMwNCauSgDg0XEEMTXepiA86JMRMOsNn+lEkGAUGhP6N8jJ3hYIT0IUdRmbJdhzBv52TpExlUeJq7m6PwAwKZKHmAsEn3PGgQfxsBc0UTrwmXot2CjUJM6kL71OBYCxOVmC85GJY0FULwo6ICg4abl7RnvXjazZJEfujyEhd3XNhDeLhxT6Pz26SRjUaJ9BVqQ9mFdl\\\\\\\\\\\\\\\/ze0ZoYd4snE6V5hB95\\\\\\\\\\\\\\\/Xte+P7lx2G5i3Norq9pIks19tPT81GGPno1wJmEoTMeWZMLLtkOkqxyNez4uUK2pGwoyMBus+AEETvjtRBIuyFDD9PedZ2KjijjTZK3DpheKUfdwHa3cBohCMi4P\\\\\\\\\\\\\\\/x9Pl45Pd8WWGDJSY85e5n6RJf61PGS2e6A+SSQ+5w6GurCJ+rRUZojz8xEu9HpiimPs3evvHFsyTnuHsQMsKqHgTjWDZe7\\\\\\\\\\\\\\\/NZYQ6YnE6WIbFGdi+wJx+f5TIxqkCLiIrqTgnOGOHEsX+RSGdWsmNFfFsnTcJOnlbFHJc+ohfnCb3U86kT3RxjuvW5PLINUEiyFupjhwiPHmRJhHJDjo+OtbhbVNVmh64QBVpGoZvn7PBpv0LHRoVnwaOinfV56MXJ80VbFL5WpoHy5bhm\\\\\\\\\\\\\\\/ix6p4OJb6TlSwxCll0JJnxW1afDi9e0MIQwwUp5r+J45l04H8Jv4OE88PWxzqVCh4UVqYyFxo0mThsVvJAkJ4CkWbMkQ94BrI3CbATO0B4HS+\\\\\\\\\\\\\\\/9tLnPYDQy2NrHDBzv4YHSaFFOIy4YBe4DDGw+VQKNiVQ5eTGhy7CGCRmMLnqu+uNcVeovujH0tgdEmy7MhVVU9uwDaJc0vOodKhQEE+jMN9W4752b05pbYYGPG0aCt0G97fROqYuWJ9FhhGViadprup\\\\\\\\\\\\\\\/g9y0Sf9IlcwKI1bVweIQjOczEgBY7azPlHCB6vGdbqP+pPqWwKHGua5L7ScfmmA5HyyMoZKuecnaEuJbCSztBqccdXZRCDCWkx9pBU4GuXgZqda87EfFeZ2aNnd6xPRMfh1JaWPaiONbDXHhYTx1ELQbxKyEEEm+F23oh4FgoxXMTTo8gRtWJfMG\\\\\\\\\\\\\\\/wjxQxqtwLiS8WFU2D1Hdr61Vs\\\\\\\\\\\\\\\/GqAQy\\\\\\\\\\\\\\\/0My7zUJBo1IgIJcD\\\\\\\\\\\\\\\/BXxoca3\\\\\\\\\\\\\\\/B0bkh\\\\\\\\\\\\\\\/G6lbtMxtyxIFwvAht0srnzJNkFsmgTaT8nH7mXK7pLf7QqBTjGXJhe9DnCARtCnKYBUkjUEEeO8VHnoneydoFVMr+O3lbHe+3pg6IF+KHt44LDX\\\\\\\\\\\\\\\/2IG132ps88ZOnoihm8b\\\\\\\\\\\\\\\/ocjjaVp+Zw5bQuMfTXUcbLTn\\\\\\\\\\\\\\\/p8YgyZwUCI90zCVh67sS17Ths+VOqe7vBZMDrD1ygq+ArLnXFNWTyTJ\\\\\\\\\\\\\\\/Xu\\\\\\\\\\\\\\\/ZH7UyHPSx6MRd4Hz1cmk\\\\\\\\\\\\\\\/bTfw40sp7T3azq53UEHKC8GzUCd9bCRqJV32lApM5WZFOXNViSGNZmy\\\\\\\\\\\\\\\/Lr3Wez3LHymj8UYJO3KBqk\\\\\\\\\\\\\\\/9fcPteYXuMza5bx+Gpzlg7HqpePaXDYWfit6zP9eK3FNGM3UqWQsDqXpde5tyZn\\\\\\\\\\\\\\\/dDHBID0trzOwQm\\\\\\\\\\\\\\\/u6cW7kirdE1ynJlueveMcf9vRlUxVCwUVqKxFTQAvGprnVdvQCmiGOGbe13nTsJbcYk82r\\\\\\\\\\\\\\\/GLdfodFh1HaX2p7TDUZWrww09z0825u8nwTq9ATaZ69VP3GC+GJIPgq0MV4FvYuTzyTKqBNBw+zBaDcR0lJDF691juIMZsejVErGOsAh\\\\\\\\\\\\\\\/+\\\\\\\\\\\\\\\/ZqT1LFTRMhSkuCfYPenBnz+YskVHGchqOk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022rTjKZU6\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/4v+b8tjaOVQQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bd15ae0ed93d117fb23e4e2e9c7b1e256899c59917c7ecd58da980be11dcac49\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/3\\\/e002218.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/3\\\/e002218.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-002218\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-002218\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-002218\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}