{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022RTnj77zzTENoVdsbGNklj6FxDKqKpQ2docZNYk\\\\\\\\\\\\\\\/899smHzEJlToyMsHB6i3AGsqZuVm17PCKHdFSpWqSfPOxkKP6lEJKYYyC+HKRWOv5x4wVTmqGLH7R+PpZz\\\\\\\\\\\\\\\/qCybfBGRP0RXCLSfttBj\\\\\\\\\\\\\\\/xQk0z2Cogj1r1TUnE\\\\\\\\\\\\\\\/U\\\\\\\\\\\\\\\/WkXwVrgY3vAAgdyWN8b+BzSF8Bjv+8l7r3hYrbAB28hwlIDABha38awyt6v9UxPjKbZj\\\\\\\\\\\\\\\/m\\\\\\\\\\\\\\\/Rh6jEO5R92y\\\\\\\\\\\\\\\/+GGoieoGKSRLF9T01l8ftjU0iVwZ69SP+tUZNt6ICT6VbmmNNbQlZY4P56oV+hOJR\\\\\\\\\\\\\\\/49fRs9rcCNCWYogWOG2r3Mbv+YRiNt7ytkI9KjQ7dbQTvCLYMUhy1JixLPcnu3JCFCZVlO6Hr4bptcpQX7\\\\\\\\\\\\\\\/HmbjNnhIu\\\\\\\\\\\\\\\/RHvGOrCn8N0o1k3l2xVMPOKThAatwr5BretKy8aTpXH1UzYNB4aEAJZVcAyvfHJ5meW4U7SllDIBkTpG\\\\\\\\\\\\\\\/yLAFvdDo9LbCi2DM9+1HnHqD2f+vnlTtQHh2qA+0Aqpvb3vAUPvu4cbEmWJRrlEnEuS+l6jstOsfYmXKoejO3KTSfmlNT16b4bOpictL7p49zoc\\\\\\\\\\\\\\\/J+3n7jqUal+KJ2bK8r2\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/+L\\\\\\\\\\\\\\\/adprjCUo3gwcnfp302esFqgk6QZNHrQ+5klBMeAc\\\\\\\\\\\\\\\/Xqp5kro2CEWFE5edzx\\\\\\\\\\\\\\\/5GZjoqZ016RetbNWiMer+5vtoGQAebCg4NzBekspyPlgcICiKMJnC7SaEQG5tfw9K7VxsdADRHL821O1YTGOVZL\\\\\\\\\\\\\\\/LIOeKhCBZJ6tmtgjEZXjtRyXvXn66GsTPsaeQlyKu0B1jOGFbhBk1qN3bK0ppcPYpyWVJE1UKTm0LvCa6fgHcXY83y7cRC0aA3D0iJSyZzUsAHQ9IeHDXJdLO2nZ\\\\\\\\\\\\\\\/YDJliqGTt2r8e9DDhFng0no3pmAF0M8z4xPYunGZNs7dxTVIE2NIk0Uc88OitMTAcuGmLfeF57cNu6ITZetOBSDyukBNNvuFDGw566aqouFne2q9NY7UM33neLXHcrPbQ4yEC91i1RO1VMPqP\\\\\\\\\\\\\\\/qvj+wovsnpcw2tfkXO\\\\\\\\\\\\\\\/tRtqdJokgyxrapxIbYMfEwTbHg0p+9mi1yXYErd7B+d\\\\\\\\\\\\\\\/HkuGBszFs4zlmfFaKfA0rPRdVjsvsjGXGzLeLps10bGg8L0wFHRmsLjAkg8haIzkJ7QYNhCuMPm7BR53f\\\\\\\\\\\\\\\/ri2lTWqrMYcwlqxoVLEG0WJq95\\\\\\\\\\\\\\\/kknJVbTuZ8M6bCVcubteo6Q6cFdWQJfZgF1bpAA\\\\\\\\\\\\\\\/hMfNQm9cnW8fBJajvqExfA1wMXD3+pWOS3E3QKe1fijRgI1YmtJErXN0nMdTZPUXq4d4lLgQNWkVoFGguNUC00cThkihdkMdZMd+t2I2R+6umlH6vfg1x\\\\\\\\\\\\\\\/cz8qEQ+V4iSD3PGjbIecdgrHklK1e16mrvfaNeUrQKEoAJpKbj171Zns\\\\\\\\\\\\\\\/hBz2f14ZyhuamTDg5YcwuyPYpBu9lu27hfegeP+a+FTRKHPCAaC\\\\\\\\\\\\\\\/MPsY69D4tbigxxobNld61T0cPk0TMdrMcfkOaKCE1Jeij2loAEu6jtwx1OE2U49bznMT8rhqU5SNIWVSOOyVSfsqtENjcRrrC2Y27a4H+UgQqJIgd8vPIh2uM9M6vM0wFP\\\\\\\\\\\\\\\/cf3PIeQQmwAttgQZhftXJ1Vx5GRnd\\\\\\\\\\\\\\\/lO2uKKScy7roXbfugQaGUnNalRo15Z\\\\\\\\\\\\\\\/9xJq2\\\\\\\\\\\\\\\/qBjh4x5wY0al12VFlpMWHVKbx\\\\\\\\\\\\\\\/7k\\\\\\\\\\\\\\\/+BKaocxsvpxnvSEJEFjDWYTYI7lGPwg\\\\\\\\\\\\\\\/O7A8cxoD8vQZxTjkAY85PyzYMYFkYeoSR\\\\\\\\\\\\\\\/1+Vvw29pD2tseZKzGvggubbx2Zkjw7DXY7eF6mu9dL3e+EQ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Nxr4bv8qbhw4QUNt5ecfKOGqPLJYdvsLNUuZBmxZDUNM1U3KdtmszVedHQUzyILXXfULVDfv4sp7rOoyqvCLxAzHsLxkE3jZ4pUZLsIIIGE3JCiGucH9PIVStXjWlwcKxitCDyjuzSpm25BibVThl78ZgD9GPydmyM7OXumFfylcZRiHJpf10CP3tNHSmBvpOY2VUvwhiFqz56G\\\\\\\\\\\\\\\/aoIkej+Y4xj3PiFzXnmZrDy6aqdTXOEUqo\\\\\\\\\\\\\\\/bOy\\\\\\\\\\\\\\\/iOwxv9CNQbR+NEi+2hg1uTM1MQvxeFO5DaycHXVDnFvClfVWdIXrZfsh67X8Jkcb9gMG4LX6QZtWtGO7o0yuuSVbF+QIlAc1jubGK0Rc+Iwydvq4OKg\\\\\\\\\\\\\\\/CtTyWHIqFrBCVV5CYB8kUpcCL+5vFJuAQ0iuJBunqTNVQubVbw3y0g8S28UmVTwBeqO3Lb+Yqf\\\\\\\\\\\\\\\/eETf66jelcr2h1fAnpkQ+V+9LLst1qJaVUZQOirUbOduM6FEReiP2xrju2LpK\\\\\\\\\\\\\\\/cOLYYtfRoohfnYc9ryx6N7y\\\\\\\\\\\\\\\/SKrW5d\\\\\\\\\\\\\\\/56R6SpEcA\\\\\\\\\\\\\\\/caFriysV1hHAbQMCDWCSPJ\\\\\\\\\\\\\\\/km8+5Zk2wWePbhiOVgMY6NNwprK5CFxSMlYEq+lmTvUliG1AAWynPzIzwV\\\\\\\\\\\\\\\/z4OJheuY\\\\\\\\\\\\\\\/8Y9fhYqksDbBQUhK89inrqFfnis27gDRiI5LmooWj1OvaMGVFhP+dqAZU1KHNZojgebcqZl6g8bPW70u1U0EgbPgUx\\\\\\\\\\\\\\\/hyfgwLXGDDcsPRwJNUYf\\\\\\\\\\\\\\\/xsicxt4JkoIc4OcNDHBLOfXZ6jKIoREkCn2T8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022EmFasK0tsMHn26fNtUAxog==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223e84f31fd2c9085e59235054a2c9cfc666d5c368ff7be434f679d273ab1efcab\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/3\\\/e001975.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/3\\\/e001975.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001975\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001975\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001975\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}