{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022rB\\\\\\\\\\\\\\\/5gF\\\\\\\\\\\\\\\/Ka77ddkUNWpPvGucFWaMzkdhtF\\\\\\\\\\\\\\\/1UGacEVC\\\\\\\\\\\\\\\/PQqlD1PTfCXSsUrsPPV1x8Awu2byCZQlf+JyhJz3uYN4fjxp8BnKbCLcqAaAVX69Zw1Pw6Fh4\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/lgwhPA12w+XABi73CL6igG4TcvnN\\\\\\\\\\\\\\\/spOi9vrVhGwr\\\\\\\\\\\\\\\/UTa4AIjfZgvSo\\\\\\\\\\\\\\\/T0GizI3gEDkF6hnL1pVl63f62dAHog22K4kRjoSN6aAERGK7ExJ6SGDKFCniBTnKYEU2Eo+GhADrle42lDcZdq7XHNEZk+Or1v8AYeHk3XSSuEVdS+6CGJp39MXt+M3dIfBewRGe0maiB7ppa8pMBGIAb8PA91wSUecuLreezvBPW1oJeJDmxZp217uW71UGO3fnwNgKTE+tJuKOJboA3sLu4wufJv+YyGtq9+6tXAdvBVtxjmKn8XGRMjnLkGo18anl5SnGiHH49OgP3BIt7G9izgSE9IHvQNdNY6ICT2iVD3478jqX0vSmiCghHvl0h5H\\\\\\\\\\\\\\\/ZhW6nc7p7\\\\\\\\\\\\\\\/PiWpuaAlfNhFDlz+XjmJIP7uFek6kbbfwoFtU1W0OY7Pd1Isv\\\\\\\\\\\\\\\/WhdEeliD6yQ9X2h0eqhfI7u+I4JqIRvWcPTm\\\\\\\\\\\\\\\/MVVs7BQ5TPgd6Z7Ns9euIQJnDwslDg5RcE8p9DOlLt1Tr8r2Tupe0GoeJq728L57GCLTOK8TG4UDolCyGOC9kJahpCOdPEH01KkB7FVaqfQ13P7U9QBLrvolKf9VWeRLQo71WYSydL341a8KqVIOTXfZiO+q5QLyF9M6CLXanLndYtoOUdht9ak73P6wPmqmRm9Wk\\\\\\\\\\\\\\\/hllGrnY8dxX8jF6MVNvF+AGmdn+gu3CL8uibFuyXnyxgGP+d7gaACSpM86yuQm25jH0qzrfWgkoi\\\\\\\\\\\\\\\/DwVoTpC9luRpKL6WxXPj0CFsqqcx1S9A4ivp502d7lbkp+WcHFcrFLzcbXba0q3EmhfuCA5BrDsSVjKI\\\\\\\\\\\\\\\/8lEfHrXRWSOj1CtbO25DfuluB9Z8ajHyN3yEPE7A0G68cKqv3I6kMp33YqESmGFkFawz+bhvRj1ct\\\\\\\\\\\\\\\/ThDXuIYJNDQVMSe+QYwvW6SmAtR7CbY5v5s\\\\\\\\\\\\\\\/3Zs+YEckNMq247KFp\\\\\\\\\\\\\\\/li9WU0QQsS9600RAttXMfX\\\\\\\\\\\\\\\/BEJmySh3fS6vhlnAQuX\\\\\\\\\\\\\\\/MaUjJaBTIdGzNhfAd42xOW6Us8IFe9A9\\\\\\\\\\\\\\\/RROJ07CccaU+wGHrpYboKyEsaWdQkaZt\\\\\\\\\\\\\\\/aCziW9CYnz7f04vLK9YxX6RCYmmOpi6fy1oP3ZBGZe5aEfeCNXzhM9lgT\\\\\\\\\\\\\\\/f4FMkCgiOhhTgc\\\\\\\\\\\\\\\/x5IG5K1WliPko\\\\\\\\\\\\\\\/EsILtLeEl8B\\\\\\\\\\\\\\\/nBtJBo9FTlFHowpwIPSyjluO5xk1wWmSR5IDFBK0pddNzb7PUacs8MCITjtoIUpwcaJQoxmP3yEhc8LfxmLvYlshqi\\\\\\\\\\\\\\\/gED7ZR7rlh1jkgXA9pYSfDaNYSwvxFWHMbUsZHzum7U+W\\\\\\\\\\\\\\\/NZD1\\\\\\\\\\\\\\\/rrhfJNJ0UHJ1ANwtsE2JbwcGja+NoKwx4jPX4aheSYYPoIZ+MxRCSpTxTPlR+MeZZ88+1LrKZjmvNIfQm\\\\\\\\\\\\\\\/qmGlLLHy\\\\\\\\\\\\\\\/S8k1HyQUePGnY1Whz\\\\\\\\\\\\\\\/HMDJk3JUUKOosBHQw5MXtZsijysbD5G+mi8qQ6wET7toBV+cMonXgQC6JEPgGiHtCWuTUcyW7OklVGMVUWayl+XWuDWnI\\\\\\\\\\\\\\\/cN94d950JO+Xzw3EiIC+5oSgwm+wbnosivZO\\\\\\\\\\\\\\\/ZqnI9Nhn8dyi4r8yhDxtCwrUNQZgmnPtBLUDozQ+8PwIqpGpTAi\\\\\\\\\\\\\\\/+\\\\\\\\\\\\\\\/ryZ6e5ZxDYAaTKX0Y0lo0tiv1qV8qWq+HAKXG1NDCDT9O2EHtG4WFC+VL+KtjfLJ+NJAvZIZK51I9LuiumbtrKg7yx2RgCZ+cV8f4OoamMp\\\\\\\\\\\\\\\/bUw+ePBOegLXKDxZY5ssHnZ9nU3CC1f8Fa\\\\\\\\\\\\\\\/P9O63IuS9d7L7UpeQI\\\\\\\\\\\\\\\/CEaQdww+MJ8QmiJmApYW3ZEZM82e36J1p\\\\\\\\\\\\\\\/IcpluUom+s7qyLkjVZe0ANX7tG75Qz42dS\\\\\\\\\\\\\\\/tPadDQKyArT7a60wt26IYAACbv5oSMxjxXYn5XeLwQLB8cyVPUTdmlcNvhuYVtWibr1NNJ45BBDiqmqM5BgN8MzhdloP00XEAgtmuX4soBRILwEoQBGk\\\\\\\\\\\\\\\/NHNOEKEVDVv8sCarQhWAlpDgk5S7ozmhVZhm3dlx9BNbs7yu\\\\\\\\\\\\\\\/kqB1PwBwRovvI1+2gv2WO4NWA2kfPSwgVDf9ItrU0YZYbvI0+QQW60o1dUbq9oDRnsDGgIgd+QcsnHMkBK3tqON2Dx5K0jx9DYXxoLVwrb\\\\\\\\\\\\\\\/mOy\\\\\\\\\\\\\\\/iryD+Mj5w783yG36ZfvBhvFyTaxRM97qeGpCoDJGyGnGk2B0u83w\\\\\\\\\\\\\\\/U0JY57fm+uoFvuSx7X6ejOHdsuKvlU9ofe0KuZ13qFNYsl+We535Mk9T72Xd8kJSwzSz6ZYuKlKOd5DGuZIXH6aZcaTUNDphmm0NhGZDKaHulaJLBLSiqAPfVIcb9f2otOGYDSLfZ9Wq9HvY2N6QMt7z7qKBXzM\\\\\\\\\\\\\\\/hRU6nKStpXXgaqryCOTq5ziJDMz13cd1QcBSlo3\\\\\\\\\\\\\\\/Y8tl1xI426+doKiqvoWd+b57rAF7dWgCeydn+nWvS8CqOpwaqdzp1piJ\\\\\\\\\\\\\\\/Vgjve0njJD4hrbirlo56oSBDz1wbNcvFMpGguh34EjO46M+5bFrviadnmo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022jcfZAw9yXRo\\\\\\\\\\\\\\\/1qo3kTz2Yg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002282b866371e45d8a141e2c780f0ee2b436c23b149b2e0da21794d943b49f1fa1d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/3\\\/e001998.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/3\\\/e001998.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001998\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001998\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001998\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}