{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Dlkg438skNSboUjKNake9YP+IBJrxb2hGTctLzF1UNi2p0MUwam6SCXprWU7tR+SmG4SwlHHOVjmcZpczmQWseK31cctk8zs\\\\\\\\\\\\\\\/P4U5fag2OIGDV1Tz2MMRYJkStZhameD2YxxN41A08MosEsH8bbsfqtZIPIv4bwiBguBOoknWZui0Plmt9SYFdltOh59h6hhdsLhFRfKEzIBAVgS87Vl0SUDu4rLGAiYA5VLB++s6BXBUwGEzA\\\\\\\\\\\\\\\/QL5\\\\\\\\\\\\\\\/B96xYOcraJsyVDWxm+yd6\\\\\\\\\\\\\\\/Qv1LkDkQ66h7Gfn6fJx8MaTahDx9Up9l0LEkydEWSTSoF0YpaUwphtzVA9VNsK2qu9J+CJx0lyq9jt2xK1CeA2qGVrQJrFL7Hk8g1ZdBge65Br8F2dlJn7vhn5De4WtLx7K9zv5RXE0fCkgGr\\\\\\\\\\\\\\\/rZEdq2S+e8RQU0BSG9G009tOlSjeWkJwLVgSL0P7iusvfGnANxFQrt\\\\\\\\\\\\\\\/aU9kRvZk1WPwbYcpaCH0Hcupz64+WDW1t\\\\\\\\\\\\\\\/75fube\\\\\\\\\\\\\\\/FECMcxK2x4zzJRbE2iT9XLuIVNbr7RdtB1wkSi1ct8TSr\\\\\\\\\\\\\\\/3Kq8CS0m4wDN+ccSQX\\\\\\\\\\\\\\\/tkxWLCFf7Tdc\\\\\\\\\\\\\\\/clsuBVSjPp\\\\\\\\\\\\\\\/0lJLGLakNQ8dlvr2\\\\\\\\\\\\\\\/EeqHUfXZudictLcxbkdhYLc3IswqIye8LT3+lN03ElrvdfC00Bziuv81XvMGyPsP+DFPzBj0PwY7gEiFq7NLYZfnsCgVYNDBOX51RJ35n7F98eInqeoqqBw97cXFTxmj6K5poVwXRlKxEwrwIWcm67RHrGHk5vQDNRRbW3i+hfXVNIfzylamlSLH676y8w\\\\\\\\\\\\\\\/Ov3aT98euStzI\\\\\\\\\\\\\\\/0E4OAAN\\\\\\\\\\\\\\\/akVb\\\\\\\\\\\\\\\/1vstMR08o8HStMBzFOzaArfTk5a7gJbs1DrkY0rQZ\\\\\\\\\\\\\\\/gvzWegShGGxl8JIvTQNezzpmx7iEmFL472+nXRC3sKDf3zOnnmkz+UTqPVqjt6ZRfpW5HEfEny+wxL7k0pabsohGT8Oh6Sto7LvzeClmEhXA+U6u3OhFG0Yew20ARPuBWv6GYEraXlbVVsbPOZ7dGk4EHdSl3vhEWylJP83Pvfi04A8X3VcHTAArKiqNAaBfjY9CW6AOco+mRUGHRd2x9Gs6wR\\\\\\\\\\\\\\\/497dEoXBiy\\\\\\\\\\\\\\\/Ij5gcAlpg8VvDNcIcALH2Q+bOICb3Aaty1y3mrkxtMSzmULofiYMGz3xmckfp7ZPPHC4ka8VmgEfhQawiJskS\\\\\\\\\\\\\\\/3dDbJ5hEk+Nh66iWqnqFI3bPwMd4ReTB4jfqoNbbuC0QPShoBmUK97wA9NOztvWn3xIHviFhLnzZ\\\\\\\\\\\\\\\/oiNVEzofU3wtgJ\\\\\\\\\\\\\\\/0nHrSQwsQxbVkffG3AlB1Q8rlAVRzmTWOEmdYR6q75yoYGZgkJ4dVlkvJOA41cx7A\\\\\\\\\\\\\\\/fDO3vlAgwafFD3M5R+IMCBhEjt2JK+Nl5EdlVqGqqwWsdK64I3bAQGdzqBt9LAHhjLA66pfUpsE1GabcGA1NNFsS0dvApy7UFExix39GZOA7+hD\\\\\\\\\\\\\\\/sfKq6NqaKcw\\\\\\\\\\\\\\\/UflHykJ6ST\\\\\\\\\\\\\\\/hWbejC1qm4\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/xCs5D143iz4oN\\\\\\\\\\\\\\\/XsHpPrPYtydLM3pWR70h\\\\\\\\\\\\\\\/0SUVnVqb3cOXv1t77v9r1PLrNCQyPPj\\\\\\\\\\\\\\\/uEbKt4Igx6qaUW6chOM2zoj4OHQZbDNZPc3oK9V5n9cljfPhhTYieWV2NH6ga3tzAJ0KWB5GnHva+33jNopZy00n0f90YGw251egTUKBagbhO05KZhP86ep97fsRHFqw3eXbul+DroTZBFL01dj0q0NPQZe9MxA0kWnZ33tWtoUgOeJCAe8Js9Ayi2HLB+EP5VAtXJHyo9getI+LYObnSbSsG7dIIMIy65opf9HTO+jWUUwr4MiTFnFOI91P5RJPx\\\\\\\\\\\\\\\/lw0Cl8KAD\\\\\\\\\\\\\\\/ZtCdsOcv4+rkhuQCaDf0OKP9hYP5Y\\\\\\\\\\\\\\\/To61TmVVHwUnoe6XgcZOGJDRaJvAYorNx2b90SM1LrtDdpS0YBz5VVp++Z5\\\\\\\\\\\\\\\/DuB1AphPHrJ8ZseLPV4aWq32CLqPHxgv8qcwnDxRwn1DJlfX0BFUdhqVoyhMBbgSxyCnmyFWTrksbtCh6NSQWbkfNuD5ilN+leWrhe6WJv45YbdI9PzwpA78LMg6JdL3D6NInCrKeyOmBJwHcH9oyHHEoGGU9uPJQCvK3EqokcyoeXURWCys9nmT447O6k1i7KqKoy5NvczeENDZjH+qA0duI986DOIw1dtcL61F13WLNPGW8tkRT+3p+gOfS2J5+Aw3AGr1gXAKmATwM1yfPZ1xtqxBHCgmI01G9caNe4c9es52+3hrFtpcFpLnXu5bF+hcpq43kLsZg2C15X7ezlc1qUV91t6EKh9oxycj3qBUACpctP+5\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/upSgCShLcvqJ+gexZc88cg9UvKr2nkg4m6Z6NE08pN5pBWZvqkzweqiHHeoHkQZ\\\\\\\\\\\\\\\/K2GTPgQgYYFYFN5hG3S1EgX1RXybrPOZq4ISH8uQYo73bQqBMcPYWAXkMmIEnvTIBrzEEiE+bo76HWNr318j09zUHkuUf4\\\\\\\\\\\\\\\/557Uh27eSAQG83Jg2hY8s2y3PzxA+tDR4U61W2k2s2GMLcYXH\\\\\\\\\\\\\\\/ECvLAOGoPAyPsCQSqSwKdFxnaRz9lEJl6Gxosod31kUKxF42OGBuIBuV9IkakHKbsOZ3BSNT5Tcq2C\\\\\\\\\\\\\\\/msOHg\\\\\\\\\\\\\\\/C9IrMoSGwg4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022M3yDxYPYVMp764hfR2s+7g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e1cabc19b57e05711ee74f461e41114ceee06d8f429d19c70c11f9a297a5a7cf\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/3\\\/e001717.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/3\\\/e001717.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001717\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001717\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001717\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}