{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022hI+8oBFYS3ortQ+uxkvejlSmKkbqlQ0kp9fL5gM1ZwTRqP+BT4vUfhl1ZCwU73jFzCssSoieXD3dRfQOIJO8WBr9y2a6hvQvq4p2eK50evcSItxUQL6J\\\\\\\\\\\\\\\/8UJu1b12oTnUHilLdFe4zpYEDqxock1RqldI9kaCKXbMm1d9ZWi+ZFHTyllgsqlirzZgltLNqJcDQCYlj5R9rnfY3exbC2tmOJxnr+VhThJwCGS5VecwL4v87ipQSGDX4aj8J4v8p\\\\\\\\\\\\\\\/XqXW2wLvsRNUhgtoQ536v\\\\\\\\\\\\\\\/C+0gWKFF1fqHDnfyDNB0EJD5tT4hwchXQOPjQJ62XkCVVGEXzDB7+3ppBIL0dUEQwj8DYd9bcftKXgYdUe4hzS6YYSpGZVZUQ5Ma0xe2vCzd7qVAbBkNx9zh\\\\\\\\\\\\\\\/RmvqmeNRBtdaMvfn32JkNKP79iEV0oEMTJuVh9U3i0wWxe6S8+kVC89AS3\\\\\\\\\\\\\\\/nSdb8HI5AoL1y7gkgivNpJLN1kK6G+41NXAJQTQo\\\\\\\\\\\\\\\/EFEMfCSOEq43VFAsT5Aope1S8z5scj8p9ujW1QWwIdzsnwnScxEHPmcuSEKCO8P0sOpbzUxs\\\\\\\\\\\\\\\/WdaQQgKuikcpiGFD7xnBafFjnXOe6DwUWJ4jS6VxJjkT7kAb9SXcrL9PeGY0J98a65uTwUGnrtnDBdS68Y4R++Vf72+HAAi+4zdj2W49agLWWkYgi\\\\\\\\\\\\\\\/ESFFlRb6EH6RZai5N\\\\\\\\\\\\\\\/37hlIP7HROf1OFzl2CLP70zShab4ezeOAMwsODfPWoDZp52\\\\\\\\\\\\\\\/C15LhopoO4WAERMtsRSxaG6xBzw+YSM1Np+AL6Dg2ICWXTUYn\\\\\\\\\\\\\\\/BYrBoSw1AgbNX0BaR4sFj03FiCoFxtowax9gmOp3gxt72yuwa0jBUfpkwmOSECzkRVdoLf1GJ5uif93uXQJxIqDnnbkHLY+jg+kGT6SYcsCI1X\\\\\\\\\\\\\\\/7OEpPfJfPP\\\\\\\\\\\\\\\/76c0g7lwV+wA5Echrc6rUO7229vkNTgvFpZUUgnaUNO76mPBEP2ys+uZatzCPS8roGGUPrh9w7jY\\\\\\\\\\\\\\\/UVCJgwWGIPMjTcVtMOjBPvrzQIgZLLSW4ZYvL2hB3IGytJO4LX+0burMfzwfs9H81UkkGzKMU5NvIlKW93LLgJ5Rifs9+OXJNwnL2ukq48ywdIopvYB3zCm0fheAnEUfPnWD79M07UjYQrsIQJ7OZYVVv1\\\\\\\\\\\\\\\/4JssZxp49S6zbWVSLIsM6kyHDD8f154mgES1njk2NU\\\\\\\\\\\\\\\/ZX54ZXWDHgt6NQgVHyBc6oYoJPCh3Sg8lB4fOFJvLLdhSmYxvHuy6pJeO5UWgD7tA9TEtowr0OdlD0veoSpZ+XCclLtJT0QEj4iO90IuRkgFsoyWRgRZqI2SXd0tvMhkPif+qt6fk95UINjHTD0ERZryKcPEoutj93WxEkP\\\\\\\\\\\\\\\/dAuG8L5AdHWlxCU+7uY1KV3la9Y1sh3q6YiAxTkT9vBkfuov5GIqehf1CDC70XgEFSKytpKVq0BLPI2NY\\\\\\\\\\\\\\\/SQGbBJIJJZ8Y+VgRVedW4kqUpXJuNRMrbEEXboiOQja7WGK5CgNsLczFqKCCG9F2X+atdTfKZiwzuHpPIFCeuIU69FFaGhJv6ogKekPD38QwIhJK3HcaunJUjWcsJxSLO3INAawn+hW7TJc64rw\\\\\\\\\\\\\\\/XqRaiEnOivj\\\\\\\\\\\\\\\/msCxx8\\\\\\\\\\\\\\\/liwkxiH6G+FdJTBkpc7U8r1CZadoT9RfgqIiEyXLgKoow1ZYcS13wgZTkrKmwnDBsQOu7+voPD1nFpHIngrDCXxI5KquOgPDRyO5wEI8wUWmuVr2lYzHdS5umfdIrRyceCMCg59AZ2Chu1Ji+zJMIJFeSxcYWO\\\\\\\\\\\\\\\/otIAq7\\\\\\\\\\\\\\\/ZMfZJeDbMP5KN+ihrKctK0nssDVOhJkhpwvCauiMorPfCur2vh5tgNqD9mVVhIoRdf1VQjrH7H0zpVtVEVKVansFoKSFwBdRMsEvfJ+qFg3OVjhZzjTdyBR2Ffk5UljtNRK5YUjMKkehSK4VxArTBGhuYEAhuC0A4pC0uDfakvmcBVWrW2\\\\\\\\\\\\\\\/0BlpkkTgodG81vw+QQP09N+p\\\\\\\\\\\\\\\/9k5UZhkmUAJIKIJkUr7UdDfZhWitY2OeSVGLNDJzvh8WKfMXQD9L4pqS7MpPeUAAKixh8TnZXp0b9rNooWvNaZlS1amTj2Mq3q0l6ofGQ+jG94\\\\\\\\\\\\\\\/2Glqhx4WW96rCULQW8vWQY1XX1kUxEjO+zMcsew9I70L2HKt0ySW0ydm+NtIY7g+pBrBLadAVtN3c4VLjGRQ10Nz5v1qX\\\\\\\\\\\\\\\/rRZSu+qTjbsj8elQnRf\\\\\\\\\\\\\\\/2zwiEaJbj0Jugat5qw\\\\\\\\\\\\\\\/3FIaUra6pv0ABvVXI1dFIEZOPzFgSAcsNGAhrWck1Rintpi9krJxFIS9cM5ozzFx82Ft\\\\\\\\\\\\\\\/Hw9Y\\\\\\\\\\\\\\\/gS18Zz29G3iDhiekEvkAIXs2i0pjlnU+29xXUR5f\\\\\\\\\\\\\\\/X\\\\\\\\\\\\\\\/FsaxkvBTbqAzzFhgKRrNRCDrxfnTIBT+30EZON1eOR6cV6vNHX3yQ7dlKPnabMCGJEbqquvNO8t77KvDpWN3\\\\\\\\\\\\\\\/2DW5ntmmJ2qNiAZj\\\\\\\\\\\\\\\/dXg9IvS1Fl9AeVKpceY0ERoe5A\\\\\\\\\\\\\\\/xOZ2QTf\\\\\\\\\\\\\\\/U+OAJHXNrVjJuDk1m4UYH3ta3xw2x+IpPRX8GHexrMXlIM4igyRatsDRgjqbw7a15GvDawZi9KfbDGGatFjDYrjjs\\\\\\\\\\\\\\\/d5jXbb4f3YTby62CbOWVRWwonIebu4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022WEWpqV3HdM5XRCl9BBbHfw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002270c331d337cd027d79cd6b9fc9bfb7d1191ff5bc3793f145edb0aa3553716bae\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/3\\\/e001506.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/3\\\/e001506.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001506\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001506\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001506\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}