{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Nx+K22OSqFzaQRV4OXH431tLXk4w3CBLpAfUFi+BUq2avmKI59hRjaP3w8glOb3\\\\\\\\\\\\\\\/rKTU3aofLwyLQwg+4aJQ5B9\\\\\\\\\\\\\\\/mibhN0EsL2\\\\\\\\\\\\\\\/zuisH0n7qS\\\\\\\\\\\\\\\/Su+0Dt2cFBlFWSehAXbSvCzL6OL2RHxRLyaBt4JDL3QuwNfPoK\\\\\\\\\\\\\\\/C0Ur\\\\\\\\\\\\\\\/Pkp6ZG1\\\\\\\\\\\\\\\/gtmzgShULWAuhZYfNiNniNiW3nOwdNIVJEgWKclzthq3INux01HXK\\\\\\\\\\\\\\\/eAb8g0uXWFdv2w99MEoqG\\\\\\\\\\\\\\\/RnlpE\\\\\\\\\\\\\\\/li\\\\\\\\\\\\\\\/WXJQKoo4OxAUZr8XP72nhVx46QSR3PdDgMMmNuiM7tsAh5F\\\\\\\\\\\\\\\/JLvdCITW8CtNtv6n2lnDRegnbhw\\\\\\\\\\\\\\\/7bNtP79jJiRLkzqeE\\\\\\\\\\\\\\\/LC5Q4MBkPy2jHlim37PjbzUlDshR\\\\\\\\\\\\\\\/lbWcg0Mt+F3eOe+4YkcGp\\\\\\\\\\\\\\\/EqLk+YbfccVMMzVQAlU\\\\\\\\\\\\\\\/qccapbtETKIlc3SP5G2Urdy0PVdBAQPcH\\\\\\\\\\\\\\\/RZYWYh8GPxD1LqlqQOJjTbQz10vFQkdjkfN0yZV7UNTw3uvTqGgKFD+8pOKhPFofYZzxZZqtl2y2LTRoqGhSFQBssmMHpa0RqAUGcGXUnGHzhNiqy52lCITCTr0SYM2NiEej4B4pyffhhzOJ10JNS5RcVpStXveRbGZan1xj7oaE7yd4bnmGU4g\\\\\\\\\\\\\\\/1bZcZykXpJPJYpb2aZrAyuEFc\\\\\\\\\\\\\\\/oQPK+zEfSb6+a\\\\\\\\\\\\\\\/fWuBPAp2VgPQEEff+7tBX4lKV\\\\\\\\\\\\\\\/R3dMnDA5hte2rbHua5zjEnpS94iGBXubE7ewGg4mUi9lXX7ZEAGGEw8QsalDc94GbM0yKj9uFGw6AUdPxssjVSBszWNObBGFGSSJqL14lZcew0bqgngxf\\\\\\\\\\\\\\\/eJ8smNrWuXGBilvCvGekRAZMPwMDAiPBxW2J+rTHE7cBLPskQ6aozU7YYnQriNk5C7OeDYe0lYOTmppSHDu426xDqIMYzCvXXVwJa8GRvLZusYWv5IETlPUmt9myym2vXZBM5IpmFGazZO7ykw4UO8WsqAywiZ1fUPQe6sPcN\\\\\\\\\\\\\\\/F0ObS60RJoa\\\\\\\\\\\\\\\/m5A5cwTkYDWZYIDIxP0UYvyOC0Shf+n3nLMKqonaDVE\\\\\\\\\\\\\\\/WSrmGObQaHTDCFn9oyqsJdq7bRuaR7gGgBNuleXZdy9Fbcgv+88RwZ5nDybOH+jAUdy8pzw7oFxnpFTf5Eo3+3eRNHID\\\\\\\\\\\\\\\/wqJPtxSR6MlwZ+taSM7KuBEqTOiIbo6GFO9riy4SmK4J5rwkKTdERkVBVNi2y9Tj0ATdZ+nYa8mUDlJgsNNq\\\\\\\\\\\\\\\/yi\\\\\\\\\\\\\\\/CxjZCAGOeDFF8mBIFUoMBz8r+Ynv94VrunLJCY0E2bp4qa9glon+GtWxzAv9QSagb4iaDDpvQvluGKOLsPZc7ciyCA7tbizt4aEeYKN1OrFVANTsyJ3hQGafmuQskt+2clcewfe1tA7Hh6yJoWV20Ej61HM+nDlh5uAPMDMimcUFgNYwOwD\\\\\\\\\\\\\\\/9f0jZxE+8o0IVo6MHQWJX1Hk9S17EHlZn\\\\\\\\\\\\\\\/PAi9iIICpup+ymFxU2mwpp45NV1LWw803XHtCvaCzgiuRGJ0cqnRyFdjhvBvJEaFnGbBAz\\\\\\\\\\\\\\\/G3o7+BDRsYrjMSz1AJ0dy4VNcLOFCJ9zNK36h0fzHwcgUIFQQVyKrAPT0jbjyC4bZpEA+O0oT5UdOQPuytd2u18QuWUcBrEjEXkuBReceiRsVajZ7APoQZALuCZg8injG8fmzpsp001TClIbhZ0Whz4XjwRlnqQeLLlu8xQ9UlHRbdQRgrwRWRRMNm5JD\\\\\\\\\\\\\\\/VHMOlupDxIA2dragVxMYsk1ipqh5bLUo\\\\\\\\\\\\\\\/2M3rBtQqGklUyo4Un0lRRZ1eZIbxH8bT9Nbn3RTwVxUBCwU\\\\\\\\\\\\\\\/7jsdjTwyVrscHZSO\\\\\\\\\\\\\\\/Xwdq+rRPccUkfUz6S6rCk1+P1NTNTpY98VBXxKGC7\\\\\\\\\\\\\\\/UJfCVfVsoOQWu93xmpdaA\\\\\\\\\\\\\\\/fS8MkGk7hDZHgs\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/whBbWvSu5zymEbIpBZvn3kWPaHcCSPKvxkDFcOpHirtZY15wcrOy7I1KKYKNR3Gms0LAoXvZh3E2EdQetYlPsAdacXR3xIZlAnvnZOSAAN82GBxD38vzWmCVjSQPYZdNtq3GiCSaDnK4q2aff1eBbtBcTIvykaCsJmfYdfEHCG6D2qrnyWpRIyI7C28uLzch5XRyewaFnf2GZxbSTJ0mbTkwfoFA8vWDUY6llU5eUZ9aey2tJ9H2p2gzYsjPpZsNjUGNCaQNS85EhW5VaPxj6YCnifS7YM9oGTnptXoC2FFhbHhjDektKWBm7gayuDrybH6wvOOsREvWg47De866of6CngiNEuQ+FMip8C\\\\\\\\\\\\\\\/Pvl1sD3GNmFNmpdVShHvNeFCQDEcSSS9OQqez4acMLEZR81KEWRw1sEffu9\\\\\\\\\\\\\\\/M4TBv+IgiKjuLo4j4o8PtsgxKIPwS6Afq4C6w\\\\\\\\\\\\\\\/6CksjkoB0SLB2Wk7t8rLN0bW+6soN+jN6XzdTEwwDY9D77Vd\\\\\\\\\\\\\\\/z\\\\\\\\\\\\\\\/PBXYKwcCGnUgn8kWP1E6C5+PwhmVgAM50oIlTTDjSC9z5bqswYz94W2t+zSlLcCFZUQ0GYqSb9u7tCa8iPB\\\\\\\\\\\\\\\/QEEoxg3eQiSTaVxnHLVG8K7\\\\\\\\\\\\\\\/jsA5NC9L0loGS14unTxndV4wEAu4MXvdXjzfLLVZNbfgp0ZY\\\\\\\\\\\\\\\/nsHsr9QYNnurf0Tq4kj7ZMx02GC3uONizUh\\\\\\\\\\\\\\\/dvV+g1MFY1dBmqhs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ogrcYYVlVB8rK28HN419JA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b7f382b65d9ee3413a324f46e0abd838cbe38c52558d062c36ac80efd1346ddb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/2\\\/e001999.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/2\\\/e001999.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001999\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001999\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001999\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}