{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Zm3JVrYj5q44r768DuGXuJbTLusni\\\\\\\\\\\\\\\/nTLc7NX5vNWBjdm4MYxZJxJhkO6Qo31sR+rYl09kJXkT4oTty5ja0oE27qy4FQmS6lEJ2q7S8Mkvmn1kC0tEt9vhXZK+31RjjVN605mdCG4IQeTYcXivvInmgOD6XV0Dg0HEEAVFI8+wBQrYU7DPJ5NCeOHe+iwo8mTRXr+LYNG9bW878mz2rsJzcl0K+TO9PZsNM1Xz3o\\\\\\\\\\\\\\\/daZ4kF6HYMsM7mx9r7HojhnEZKx+gwGNxACOXoQsJ6UfELkOl\\\\\\\\\\\\\\\/XRXCu9RA6tNAaUIodDP+VYry3rG5byLVrirRcTyzOxrSN\\\\\\\\\\\\\\\/vuUWeYsp223kf\\\\\\\\\\\\\\\/AfzgwLBgyjg80DdtQ7+TRVcEEDY3P5Qp4OyPvynAd3Ql2NwSau5liT+BBhfDKaGL46tUbzlMEz5\\\\\\\\\\\\\\\/faxUXLjabLHhkGsRjnNKg4XLcA4Pc0MF9JVZUhljw6AVZsugW8HlfaKTWJeScfUQrqSc\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/OqXVm\\\\\\\\\\\\\\\/Tf2nbpEKifTA7uqxKSOhfVt8d7zhf60cslpVqY0c9p8bUbmP5qFj0bwvslPn\\\\\\\\\\\\\\\/hCpfdy6om9EYF2UcP42g2vC+hiB762aCeuBYtnAUTvI5IUe1TVgEqH0XzFt7HXtuXM3yvgQ0Q9aHrnPqyv+bo3xrv68a7pWZ4qxRh4Q\\\\\\\\\\\\\\\/O2yC20FjuXArqbs3++0mGkyRyiJGoLHesw0pk1+2yXYOQZbcTXuBSePVw51ztryYl7YJCal6NCdhlpidEe8bOGwiliOWuhSBGyMZKyz7imFZzcwDhzZvAHhX6SUoDHuSCZ8vclW0pGdwm3u0MjYKMndi2O6GKxv6gYMoi\\\\\\\\\\\\\\\/TA4x8LYZz0\\\\\\\\\\\\\\\/+wrmDeLVpkjKvLFI1Q6dW5fV6U74OXqeETCAsTYn0Iz5oIuxXVk8fFFa99L1iXSwyQjcFXbGZLbxF6a+LxjampPt8X0sUHuqNMlx9TB1fdLcRblZKgdSzF+qA6U1O1hYT5NGOb1UDdPmwzR5g0FPXOGu6fTFllZdLXxGA0zN4hOTmX29nzTL3v46Bw9lRaQ6vNvhOGDSSpHgrQcVpGH0h7STdRVwfHaH5OOvyICjGfVB3YIy3AEWE87sVtDvEiO7qZStX5FB4nBRzPt9\\\\\\\\\\\\\\\/mIzmhAw7TM7Tc0WdvuvPFhTzL400rt7GDDICSB7VWOwbeL6BF6M4mSNiee+YTBzyyjQh7lURxID69KXazCUVt7Q57\\\\\\\\\\\\\\\/3KprxbJxM2aBjqwWQ\\\\\\\\\\\\\\\/isZ\\\\\\\\\\\\\\\/J7XMa82BNgbGsDg97IoCeCkYl8a+UIkBcyXhk7y1MUD69rGIri\\\\\\\\\\\\\\\/PpandQDv65Zsk79H2z5OEYfWtcjnBmuDtpZNQR8lVwTy02Z3gC+XLq1PoHB5uVwqeMjOgml8bk3Hb5szreXOd5EhEOaPbvL7g1ahJYqO8ZU0UuKtIHgwKkdKY0oDQJ6fjS1XnHjknx3+h7bVaEddEDG12x2XP2wRzizWxBjhw0xzH3eCWZt4LgyVRMXwRTKuMVNN3ALKu+7s0T1JyttPNGZiI62POkyitlhbXOwcfRkpDx1UpIzc3V10FDvTlgQ56gCw9XMKWzPyjFdrSioIsZys6p9lYS9GEoWS\\\\\\\\\\\\\\\/W8zmgaJmSVL1Q5LrEJIhYQz+DlP4JsAdL8LJpX8T8oUxhJ2babv2v6Luy8xqnB4hTqdkkSLvggEm\\\\\\\\\\\\\\\/35dPtoxBpFx\\\\\\\\\\\\\\\/r7+yw3h2IE03x6rhhnuMJfldJF8q1brMjYJTeYhZQhZ5Wz8\\\\\\\\\\\\\\\/xrcS4\\\\\\\\\\\\\\\/AVVRzszji8VPaQvmnAYwRiHY2MxsPMTsDDhOO3vJwJ4ut\\\\\\\\\\\\\\\/Bbw1l8F2+jeLQQcv\\\\\\\\\\\\\\\/ArSonZccY8XZd8j5bI83pVW\\\\\\\\\\\\\\\/yQnEweZgFWD18SN83\\\\\\\\\\\\\\\/eKT+Wcet6UGXlVejWtPhyFpECQUjt8LHQgk4dDA\\\\\\\\\\\\\\\/5W5A1FRE63TJoCbjc5QjcJTCzuhdfgzLnepCsawu56Mo2DMVtqUMulSqE0z0Is8Yw5se+zkTJBmtIg9pjYIm6POrjKLZd6CRCDb0L\\\\\\\\\\\\\\\/KDBBC44c\\\\\\\\\\\\\\\/7sSSe95BeM1wMIndprlzQsgo3titOy5cWrpSDGBgfcMLYkw0REskjqjBKQxVatJxA8W8fcD8cudPpeXPColi8oue2mo3ph4jl1qoi4\\\\\\\\\\\\\\\/11oX8MxoUJpF1QPRGqbLLb\\\\\\\\\\\\\\\/55QGHKMj7Fw\\\\\\\\\\\\\\\/S6oL7o2tvrOToRLeYlNJfpEd1FtTuLdYwPqNr+KZOsHtxVcmn9GB\\\\\\\\\\\\\\\/TZFUFrAP90fih+c9\\\\\\\\\\\\\\\/f7n92czivnu0W04mMYZUXc7Aqz4N0Hz+0G+e+pAS147iyLHrAKU8tQN7QZXUl9APUCaiYs6s8B4sFx8ozdnlDaViRukVNok0pYD+nFB9wVdSgtR81beCqIoSWy5QuoBcnkGVNf1MoXGzXxmLtMVxIy57iUg7zXlGmXVPJpqubzXXfBkRQlP+0xK26Q0jSR56OTSoEX+4EQGWyrLeWPGA7vTszMus7phDMnxFIbJtSp2R6UKw6RLFuQhADHT89TeNjYRJBy4uZuWny3kcqgUV9RI86saVMi8pFDg3DTSfndFEi4pjST14IcK\\\\\\\\\\\\\\\/q45+\\\\\\\\\\\\\\\/L8BzENMl\\\\\\\\\\\\\\\/j1S54diIRtVGJ+yNp9HJMpfqtZKE3FuZGqSpcNNjNGxPT7x19jKvNDmaHaAu1ADWolplBWcHCEJKHaUPlwzd+hbb2zddaKSv4OeP452c=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022uGiR\\\\\\\\\\\\\\\/BNL+zjkrqo1h5I95Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bbe3839d1e856c525c3ac7c8970f8d378bcf2f583517a73d96fb3ada6d1633f6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/1\\\/e001762.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/1\\\/e001762.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001762\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001762\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001762\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}