{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022wHmMYviBh235hHmrRJd7\\\\\\\\\\\\\\\/YcjmlDjbYJMvtrGGxEHUBGExp4Uh5gmd\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/WWglrVGqnP7JV\\\\\\\\\\\\\\\/QimLl0ei8m\\\\\\\\\\\\\\\/kP\\\\\\\\\\\\\\\/vnZt5fdDF4H1pGNLIRBVO4nbPQLCYrgFAw3zA4vxxU7z95ye6HCmstnE+dUYG1BZc1xzeeL1BsUbKVAN48n2kLYgcrhtBdH2iDqEBWu23F\\\\\\\\\\\\\\\/kKFQdPXeLXeana0AWoQe+zOPzPWl6OrQFSlsLBX4GWvENUyPY7H\\\\\\\\\\\\\\\/UIY266pz0HyHFJuncsmGJSbdVROH9wY9Lc9dlgfir6AeHpSRF2dNBbwLPLBBGD3KgpEJORvuRt6GUcYoZ320G2g3e\\\\\\\\\\\\\\\/LKJEhuu\\\\\\\\\\\\\\\/QZVr7MgeIBWyYGplbQR7UoX+LQp58AoVFHw5nIcc47klE1bs8pZZPWU5OIia59OqE7oKo9MEpBNPxM7aBSRxqW+FKsDZJRBRBO3RJvzA94KI8bCzJHzW5P9io\\\\\\\\\\\\\\\/CULs2asBrpxfr2LPMfpNM7A5hdwf8+puBTSs6DfVvX+Af\\\\\\\\\\\\\\\/PFqkWYJC895Iz0EN6zoPu3nUjSRP\\\\\\\\\\\\\\\/icjtkMsmyQx4dSjMc+slNQaK8UWQ06eey+Mifv4sFGJqrUY3No67VFl6x+iOjuOf34VXzx8svnZopUrx+Y2UeFsyetER\\\\\\\\\\\\\\\/HRbJYqss\\\\\\\\\\\\\\\/rYHUTMm08hEodCwPCL45IeIEmoqYts4HA8vUT\\\\\\\\\\\\\\\/1xDzf8Lj64QvQ62ss5wtKCbF6+eZ2IFraNNdLNgvafmG3l\\\\\\\\\\\\\\\/O745\\\\\\\\\\\\\\\/rhDoka4tj4puMG\\\\\\\\\\\\\\\/DwyQ5HmVDG5nKgC3dBUVpMO+Fd\\\\\\\\\\\\\\\/Bz\\\\\\\\\\\\\\\/6SDBEkML3Ty7QmUYGsltVmHyjG1i9mgbvjwuRvYYsl5qggQQ9kS14AhJqHvBGkduQhVxpzPFoLCzE0LEwta2vu70Xqb0r9Wa7Y4QnOL2t4u4dclOJhHGTOnayfnamiCmMSj2CaGrgOI8VTIRECLuN3tr+SSlG2pkFHy8e63zL\\\\\\\\\\\\\\\/+ImkjrZg5FOVTnHwfMjHNJSHfzChnUMz9PRQGlbIrsAEB2bUgK9a\\\\\\\\\\\\\\\/GB4Yi9djQNTd5wsthamuJzvJZGgQPi+2JRzmurnhjowz7OpycX1mSjrTQObYE6cM\\\\\\\\\\\\\\\/AY6NRcWJoG4gj\\\\\\\\\\\\\\\/LiXdHzuhJEW4tWgQglzU4BxNsF4vfOS2mE5zjJpIIzNFfVesaMozV+qbV753CdljLWvLmjDp0ck1HVrdk5JEGjy4OaQPXssJAJtEgUUCVWHgf9v2kd+8UVtfmqVuHUez1gWRkHNbHvTeMaIrR2amfqAfs0h5xpXvHs7ho0OBYd01emiQRAXFq6+vUP4+3x+6g8Ox2xAvH12EQhzDmn\\\\\\\\\\\\\\\/I+hDkd3rpbksnq4UPSwB703y9vihdYMOefx5BvwjaGZvs\\\\\\\\\\\\\\\/VMElBSsoY11MSra+jsReE7Vfe\\\\\\\\\\\\\\\/j9HghhsBD9mWoOMNzbNRF\\\\\\\\\\\\\\\/TUEvgnr+mNEAc2exive5Drn\\\\\\\\\\\\\\\/+TNfp067vT8ZDbs+49EG7qa20qlBuaxAvroBXNs3wIy+EDnHLe7ou3YpLRqNXlaJCy9+JVhr1M3YukIyzHpVSL2G6lObH4CQ3vGf7XXtSXnho7sUTeqtFNwiuGaLzG6YHBpKxM3874yCxXYziGub7UpJemWdqiN2lt8k83EE1zS7KH7EtOuVH\\\\\\\\\\\\\\\/LJYZhOa0F\\\\\\\\\\\\\\\/YP0mWlNuMgsGaQh07sNcaPKX71YrxMd5JliX8DeqgUHkgMZsOB5VJA2yxRKyygJ6IVzhJgaErTdydCz\\\\\\\\\\\\\\\/32LWJCFACvi9uy2cBF8cF09SJcbEF+nQavsImhpIoP7ph5Dx1HTOaX6r3J21pxBFfL9W0GlLH3AvHKLA76ekmjs16mjZw3Kgy6WRUOQuTsvdAA0bYSb6mjD8jycbfUPY5mEbs3phJFZgyKnN\\\\\\\\\\\\\\\/Vd4aTgoBUR+aViKKxIjreKJFopVyvZYApv3PC1W1Z7emCH0eKb4eMb5ruPhA8nLgX5Qq1ZJnXwmvdeBEcqpV9NEseIzLVwAAiaGQ6+IrAFLwcZkaLZ1oI1X1QoEiP7qAEdLf59dlayl\\\\\\\\\\\\\\\/WGyfOQuWKKM7x5y8VpFyCZrQMi7gm1SKK8qis3Oh4ntjsFLavcdRxlhQYQS8+6DAD25abzOzrO8osZdmP0Jga3Xn7h+dyyC922tHe9iEAyvKZMaNNxMwQzBZd8GEsY8VfyM9RMXu6YISEMSO9Aj96gMD4RANFmqZ5OfSVBd0bAIcmDFgdFuIWZJ7Pn7qCvdwmQqMeGcTSalFEYf0XCagrAGThvUChh6a+4QVGzNDMpnqdEpwMKpeA7eBfZ7wZqe+IduQrYYSTlF4DiDXUikmS1dyNXjBvpvnp2dWScnsMurqxqUOy3crqJUzqaGI89F9yHRMy7UytaYLhKRVOe0JCMFda8xA4SB0dgNNRKJ0HfLgyXizup+Hb\\\\\\\\\\\\\\\/YMYzsEr6dx2uEiBGpHbHuRyTC3pP7f3dHiuqvoLsljkO4UF4ZOjb+2Frm0XSE67GPp\\\\\\\\\\\\\\\/QPBsnWJF3tH076ReBVZaiuBAJFv1kNzGZvSzRVEdC8V4prOS6awl7g+dZHyI22OHbUDDp7rjk+Sj\\\\\\\\\\\\\\\/tY9Ro0QhPxLkPq5zcz0UdcDkZB80jDDSZJYXANvZ01pC+o7IgJb+vWJQoRt\\\\\\\\\\\\\\\/TZY4K6XLESys4FePuDz\\\\\\\\\\\\\\\/bQJq+5FSEYzzZYwC3MsPaGFmjsoyEYV8PmHaF35EvVg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SoTxKRW2jeae2PX2zgnriA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229b1697d683585b695883c9f823051173efd7c601f81d806646e25f8d72120a36\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A338.2.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A338.2.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0561\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0561\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-SITC2020.0561\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}