{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022jrilQlDt8wRvSXzWU6Fe7f0Yi8g5s0YtnG\\\\\\\\\\\\\\\/zlfrgWESklL3ltzlBBOTG+vvPzvYT6L7mm42xchAE+U3hq3mwH3pOLv\\\\\\\\\\\\\\\/Rh0LqHvnCxIOLq4034GrmL8D6WPGGsI5Bt3L9wG0gDUXLZeLXHPzftQ+TY1Sb0ht0JjMKN4BuKuCCWF+YkXFdXTE4sLh9BYLWf0+B1HYn9tqfuXlfTlTxtUaFYxZ1bEjHWryuVq37DigOGA2Rm0GaltL9jMuDoZSwUUrvI5IL\\\\\\\\\\\\\\\/bveaD1kTxmmQzbD4a2TXoiqkKzlMZCoAHGo2nzwyTj5O91V1Ll4YUyGCHbdrQ9S+XLZcsfhc77woix8lvaWeKpkXO32H4EoPzozVRAFzX75KEP\\\\\\\\\\\\\\\/lDaYxFdrQRPmKgu0OUc7\\\\\\\\\\\\\\\/pB4cKUJjh1SIatdaM28dDE22euSLOjv2iayWOHTAtHuimf4mGFK6nQfVAEB7bFAz2nE86Gtl54O7\\\\\\\\\\\\\\\/75+Ze+3tEM2jhblykMz7oJIYb44BI6qG0KoeJ9rZiVllSU95NZwEqKWdQwGp\\\\\\\\\\\\\\\/fDs41U9v7NYT2TT9JXE79B22VkalD601ifprd7hkJA5HkbAnhOPS5vHy8ugQiI+oALLF60bwhc5UlXGp10j\\\\\\\\\\\\\\\/rx5Klataco6PSkh62IKAY+uxihIociyH4Q8FRESDc5XMgIDS\\\\\\\\\\\\\\\/QnRgxClwAVxgCADUTwwHAdxbEXXvepPfOdvjluSCtflDoe2szz2oIuMC3WhfDWPnk+gGitHV5YcuhnpjxdtU\\\\\\\\\\\\\\\/E3UNJ85Jvl0WbdjMBD4n\\\\\\\\\\\\\\\/eOh7jkG8NOt9Kt+UuttOavwFQZ+sstv6JOnKe9pALy\\\\\\\\\\\\\\\/B4OagEbI0\\\\\\\\\\\\\\\/dwErp5fj0oMPeLNA8csryLPG9Rn3soM5S5zA89s3Rz\\\\\\\\\\\\\\\/XiHwogZoej6+sY0YPYtRlbX+9g\\\\\\\\\\\\\\\/dxUMcaRUZ+xhqdxXdfxd5p\\\\\\\\\\\\\\\/YYez\\\\\\\\\\\\\\\/CJG8YrhP+hvMiU72x8t+XX\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/zFQTVdzmAi\\\\\\\\\\\\\\\/prRnddGSfvF7MYbnaYEFQkjI69rlHzUDKyEGDnG6eacl+BAfwy2ybwG3BhdUzOS\\\\\\\\\\\\\\\/LO7VnSyuaaNTH5nMvaBmYuU0dcbN3EmxkxzwuQrSkFWzPxOVRnkDZX613zUly8S5yJi6j9w1cINB\\\\\\\\\\\\\\\/nYZ7rg+TVTtCsWysfXOWYn8ZrR8dbPm1IcfkYhk+Ubp+aQ2HPKfDHlTPzPMADgFHse6T6i7kFtwEnMATREudkkr7awFvZ092u3PcKvPN3Zms6spr80ZXSxMg1MoUyBwCyvYWztiD1EoYdnZ+we9J\\\\\\\\\\\\\\\/TeBJwI2F3ejlFA\\\\\\\\\\\\\\\/u8u1VwSNsC8tUYDq8Iikpg1bmZMSxX6mIE9bGXQ23ppFc4UWybmWYlWUy4lMDekf9z5X5FOdEYvRIn4oFO0Pj0I3BUkWCkdiqOmOnWPBZrMArEp5Bfie+lxMW1cpME\\\\\\\\\\\\\\\/1CtW+cEQ0mHhKWu8urG0N\\\\\\\\\\\\\\\/Fk\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/EI70uD1wvmp0AkWXKcnpGha0R9lPWrHXeiNnc8KmZuBOnffnw+vyrvcDHxkBkwOU1lrtWi\\\\\\\\\\\\\\\/V1uJkjiEXUa0r4HrcxVBRpbdhkbnsQjR\\\\\\\\\\\\\\\/w6VIho+WT5Zu6eOLVOYAODvbODCx\\\\\\\\\\\\\\\/MpNh+iJmEPE1c+6NeuuQYax+u\\\\\\\\\\\\\\\/Xm4ud+RxlzBRhcCkTq6c3ofMTh+QdyfgKfitvGEj9Zg+VBUZZpZuPUnWLjNVjW4gkIW9zZKehE20oDw4Y6rDv91FCMkGTr3HF2+mTYnE9sf\\\\\\\\\\\\\\\/PmLSmsnDg70rbz5xNqE5gH5MnzXDyRxiJr7URCEpNvwFE1DHAdjuaXcCljuPP8zqUVw4qWFjVRH4qsjHFs+ByxU+invjnyKq4kPzzsUyNURJdvBuFHc\\\\\\\\\\\\\\\/83HTQgcJYj2UbyKKMNKykMdZ\\\\\\\\\\\\\\\/+KeO0tXzTndICgqZHh\\\\\\\\\\\\\\\/JE0WCXKLZCn48MZ9\\\\\\\\\\\\\\\/qvjGKaEHAUKI00d5cl7hRF84AzvHCI6vnQ7gpPjxgrcWMHN7m156luK1xZv2raEc1DXmnnDMUj9Ya1uoxO0C0Znjp663DCMQdOdsuYpgER6xh5zIrDiHvMbIwGaV62WjWbMe2FDdRdhh+EbbWMD4\\\\\\\\\\\\\\\/qukh6KjwUuAYCp1wvIGNvtnU\\\\\\\\\\\\\\\/4LmGCVObpQYba74NWyGDIsWlhYJa+jo3RL8eYdoZBsI1ImBNi\\\\\\\\\\\\\\\/ODFpDg9xOR\\\\\\\\\\\\\\\/eGGx3+0U6e\\\\\\\\\\\\\\\/u7sev4AAUpFRBA9zs1jMJsPSyQv5S12mXZ7SttGXeVmvf+nNj8+Iw+iTt1zV\\\\\\\\\\\\\\\/PvDLKugRnI+zq3zBqtgBKm00htJmHeQz3jsAsriksqwn5+nygm7nGhbu+RnO+rcGIBFC8suiIMFjRt9HfO5Hnl+tQc8G037CFQn0+qiWEU3ICfQVg2DEQyulRRh1RFUGApBC\\\\\\\\\\\\\\\/WPjbGELV49lphUBCzoBUq96bjs96EIP0azVbWmdQk3N7MUOJFeenJvnXxodU0qeM2OMjQtoD6VHqy7xl62m8wFVPG4fqYeJrvKqlULsCsJVbyNZfFTmsHBIt9Q2PpuT\\\\\\\\\\\\\\\/KWP49FrqWGtqwxrv3lkMMTLv9x5lDDREDZEHPClZAdQ1EFqAdI21xV5\\\\\\\\\\\\\\\/wec3dDJh70urJmvuQH\\\\\\\\\\\\\\\/xyY9Tymy9c\\\\\\\\\\\\\\\/sXAzWZjCv1FM+WXeDY6InfgGqpLzVJgszhNqAQ6v3KoXMLIUJh4Mr9CZnBzDU0FsHCS9ce1F4pEGgffGs6vxleBwZFg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Dz1aUOheG4Asn6JwXz9omQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002245e1983e141e99d05476ecffa6bdedc59979c70726381970eac2a84c91eba6af\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A500.2.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A500.2.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0837\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0837\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-SITC2020.0837\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}